Propamidine
- CAS No.
- 104-32-5
- Chemical Name:
- Propamidine
- Synonyms
- DAPP;Brolene;propamidine;4,4'-(1,3-Propanediyl)bis(oxy)bisbenzamidine;4,4'-[1,3-Propanediylbis(oxy)]dibenzenecarboximidamide;4,4'-[1,3-Propanediylbis(oxy)]bis(benzenecarbimidamide);4,4'-(1,3-Propanediylbis(oxy))bisbenzenecarboximidamide;BenzenecarboxiMidaMide,4,4'-[1,3-propanediylbis(oxy)]bis-
- CBNumber:
- CB9897768
- Molecular Formula:
- C17H20N4O2
- Molecular Weight:
- 312.37
- MDL Number:
- MFCD00866601
- MOL File:
- 104-32-5.mol
| Boiling point | 497.3±55.0 °C(Predicted) |
|---|---|
| Density | 1.25±0.1 g/cm3(Predicted) |
| pka | 12.75±0.50(Predicted) |
| FDA UNII | G20G12V769 |
| ATC code | D08AC03,S01AX15 |
Propamidine Chemical Properties,Uses,Production
Uses
as isethionate.
Definition
ChEBI: A polyether that is the bis(4-guanidinophenyl) ether of propane-1,3-diol. Used (as its isethionate salt) for the treatment of minor eye or eyelid infections, such as conjunctivitis and blepharitis.
Pharmaceutical Applications
A synthetic diamidine formulated as the isethionate or as
dibromopropamidine isethionate for topical administration
to the eye. Resistant clinical isolates of Acanthamoeba
have been identified. It is available over the counter in eye
drops.
Its activity against bacterial pathogens is poor, but it exhibits
specific activity against Acanthamoeba spp. Reduction in
sensitivity of Acanthamoeba during encystation might reflect
changes in drug uptake. It is still recommended for aggressive
treatment of amebic keratitis (in combination with neomycin
or other agents), but is not well tolerated.
Propamidine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Struchem Co., Ltd. | 0512-0512-63009836 15365350169 | helen@struchem.com | China | 3989 | 60 |
| Chengdu Saiousi Pharmaceutical Co., Ltd | 028-64971018 18108168130 | China | 1781 | 55 | |
| TCI (Shanghai) Chemical Trading Co., Ltd. | 021-61109150 | sales@tcisct.com | China | 31183 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 15229059051 | 1027@dideu.com | China | 9902 | 58 |
| Hubei Enxing Biotechnology Co., Ltd | 16621771607 | exbio_tech@163.com | China | 8362 | 58 |
| Nantong Zhonghe Chemical New Materials Co., Ltd | 13003551299 13003551299 | 2369399482@qq.com | China | 7568 | 58 |