ペチジン·塩酸塩
ペチジン·塩酸塩 物理性質
- 融点 :
- 186-189°
- 沸点 :
- 282°C (rough estimate)
- 比重(密度) :
- 1.0858 (rough estimate)
- 屈折率 :
- 1.5200 (estimate)
- 闪点 :
- 11 °C
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- 水に非常に溶けやすく、アルコールに溶けやすい。
- 外見 :
- A crystalline solid
- CAS データベース:
- 50-13-5
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
絵表示(GHS) |
|
注意喚起語 |
危険 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H301 |
飲み込むと有毒 |
急性毒性、経口 |
3 |
危険 |
|
P264, P270, P301+P310, P321, P330,P405, P501 |
H336 |
眠気やめまいのおそれ |
特定標的臓器毒性、単回暴露; 麻酔作用 |
3 |
警告 |
|
P261, P271, P304+P340, P312,P403+P233, P405, P501 |
|
注意書き |
|
ペチジン·塩酸塩 価格
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
ペチジン·塩酸塩 化学特性,用途語,生産方法
効能
麻薬性鎮痛薬, 鎮痙薬, オピオイド受容体作動薬
商品名
ペチジン塩酸塩 (武田薬品工業)
化学的特性
White or almost white, crystalline powder.
使用
Analgesic; sedative; anesthetic.
Controlled substance (opiate).
定義
An addictive drug,
use by prescription only.
臨床応用
Meperidine is a μ agonist with approximately one-tenth the potency of morphine after intramuscular
dose. Meperidine produces the analgesia, respiratory depression, and euphoria caused by other μ
opioid agonists, but it causes less constipation and does not inhibit cough. When given orally,
meperidine has 40 to 60% bioavailability because of significant first-pass metabolism. Because of
the limited bioavailability, it is one-third as potent after an oral dose compared to a parenteral
dose.
Meperidine has received extensive use in obstetrics because of its rapid onset and short duration
of action. When it is given intravenously in small (25-mg) doses during delivery, the respiratory
depression in the newborn child is minimized. Meperidine is used as an analgesic
in a variety of nonobstetric anesthetic procedures. Meperidine is extensively metabolized in the
liver, with only 5% of the drug being excreted unchanged. Prolonged dosage of meperidine may
cause an accumulation of the metabolite normeperidine. Normeperidine has only weak analgesic activity, but it causes CNS excitation and can
initiate grand mal seizures. It is recommended that meperidine be discontinued in any patient who
exhibits signs of CNS excitation.
Meperidine has a strong adverse reaction when given to patients receiving a monoamine oxidase
inhibitor. This drug interaction has been seen recently in patients with Parkinson's disease taking
the monoamine oxidase–selective inhibitor selegiline (Eldepryl).
The elimination half-life of meperidine is 3 to 4 hours, and it can double in patients with liver
disease. Acidification of the urine will cause enhanced clearance of meperidine, but there is a
lesser effect on the clearance of the toxic metabolite normeperidine.
安全性プロファイル
Poison by ingestion,
subcutaneous, intravenous, and
intraperitoneal routes. Moderately toxic by
parenteral route. Experimental teratogenic
effects. Mutation data reported. An
analgesic. When heated to decomposition it
emits very toxic fumes of HCl and NOx.
ペチジン·塩酸塩 上流と下流の製品情報
原材料
準備製品
ペチジン·塩酸塩 生産企業
Global( 0)Suppliers
名前 |
電話番号 |
電子メール |
国籍 |
製品カタログ |
優位度 |
50-13-5(ペチジン·塩酸塩)キーワード:
- 50-13-5
- MEPERIDINE HYDROCHLORIDE
- 1-methyl-4-carbethoxy-4-phenylpiperidinehydrochloride
- 1-methyl-4-phenyl-4-carboethoxypiperidinehydrochloride
- 1-methyl-4-phenylisonipecoticacidethylesterhydrochloride
- 4-piperidinecarboxylicacid,1-methyl-4-phenyl-,ethylester,hydrochloride
- algil
- alodan(gerot)
- antidurol
- centralgin
- chlorbicyclene
- chlorbycyclen
- demerolhydrochloride
- dispadol
- dolantal
- dolantinhydrochloride
- dolantol
- dolaren
- dolargan
- dolcontral
- dolin
- doloneurine
- dolopethin
- dolosal
- dolvanol
- endolat
- ethyl-1-methyl-4-phenylisonipecotatehydrochloride
- ethyl1-methyl-4-phenylpiperidyl-4-carboxylatehydrochloride
- isonipecainehydrochloride
- isonipecoticacid,1-methyl-4-phenyl-,ethylester,hydrochloride
- lidol
- ペチジン塩酸塩
- イソニペカイン塩酸塩
- 1-メチル-4-フェニル-4-ピペリジンカルボン酸エチル·塩酸塩
- ペチジン·塩酸塩
- ペチロルファン
- オペリジン
- ドラルガン
- 塩酸メペリジン
- デメロール塩酸塩
- メペリジン塩酸塩
- ドルシン
- ドリン
- ドロサール
- リドール
- ドルコントラール
- 塩酸ペチジン
- ペタンチン
- ピリドサール
- オピスタン
- ドランチン
- ペチジン塩酸塩 (JP17)
- 1-メチル-4-フェニル-4-ピペリジンカルボン酸エチル・塩酸塩
- ペチジン・塩酸塩
- 麻薬性鎮痛薬
- 鎮痙薬