β-アラニン 化学特性,用途語,生産方法
外観
白色, 結晶～結晶性粉末
溶解性
水に易溶。エタノールに可溶。ジエチルエーテルに難溶。水に易溶。多くの有機溶媒に不溶。水に極めて溶けやすく、エタノールに溶け、アセトンにほとんど溶けない。
用途
β-アラニン(3-aminopropionic acid)：略号β-Ala．タンパク質構成成分としてではなく遊離の形で，またはパントテン酸，コエンザイムA，カルノシン，アンセリンなどのなかに含まれる．アクリル酸やアクリロニトリルとアンモニアから合成される．淡い甘味のある斜方晶系(水)．分解点197～198 ℃．水に易溶，有機溶媒に不溶．パントテン酸製造原料．
効能
アミノ酸補充薬
説明
β-Alanine (or beta-alanine) is a naturally occurring beta amino acid, which is an amino acid in which the amino group is at the β- position from the carboxylate group (i.e., two atoms away. The IUPAC name for β-alanine is 3-amino propanoic acid. Unlike its counterpart α-alanine, β-alanine has no stereocenter.
β-Alanine is not used in the biosynthesis of any major proteins or enzymes. It is formed in vivo by the degradation of dihydrouracil and carnosine. It is a component of the naturally occurring peptides carnosine and anserine and also of pantothenic acid (vitamin B5), which itself is a component of coenzyme A. Under normal conditions, β-alanine is metabolized into acetic acid.
β-Alanine is the rate-limiting precursor of carnosine, which is to say carnosine levels are limited by the amount of available β-alanine. Supplementation with β-alanine has been shown to increase the concentration of carnosine in muscles, decrease fatigue in athletes and increase total muscular work done.
Typically, studies have used supplementing strategies of multiple doses of 400 mg or 800 mg, administered at regular intervals for up to eight hours, over periods ranging from 4 to 10 weeks . After a 10 - week supplementing strategy, the reported increase in intramuscular carnosine content was an average of 80.1% (range 18 to 205%).
化学的特性
This is a secondary amino acid, which is formed in vivo by the degradation of dihydrouracil and carnosine. Because
neuronal uptake and neuronal receptor sensitivity to β-alanine have been demonstrated, the compound may be a false transmitter
replacing GABA. A rare genetic disorder, hyper-β-alaninemia, has been reported. It is used as a flavor enhancer, flavoring agent,
nutrient supplement or adjuvant. β-Alanine has a slightly sweet taste.
天然物の起源
Reported to occur as a component in amino acids; carnosine, anserine, pantothenic acid
使用
β-Alanine is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of dihydrouracil (D449990) and carnosine. β-Alanine is also the rate-limiting precursor of carnosine,
as a result supplementation with β-alanine increases the concentration of carnosine in muscles.
定義
ChEBI: A naturally-occurring beta-amino acid comprising propionic acid with the amino group in the 3-position.
製造方法
By heating acrylic acid with concentrated aqueous ammonia under pressure, by addition of acrylonitrile to phthalimide
or to ammonia; from β-aminopropionitrile, from succinimide by the Hofmann degradation.
一般的な説明
An N-blocked form of alanine.
純化方法
Crystallise β-alanine by dissolving it in a hot saturated aqueous solution, filtering, adding four volumes of absolute EtOH and cooling in an ice-bath. Recrystallise it in the same way and then finally, crystallise it from a warm saturated solution in 50% EtOH and adding four volumes of absolute EtOH with cooling in an ice-bath. The crystals are dried in a vacuum desiccator over P2O5. [Donovan & Kegeles J Am Chem Soc 83 255 1961, Beilstein 4 IV 2526.]
β-アラニン 上流と下流の製品情報
原材料
準備製品