ベナクチジン

ベナクチジン 化学構造式
302-40-9
CAS番号.
302-40-9
化学名:
ベナクチジン
别名:
ジフェニルグリコール酸ジエチルアミノエチル;ジフェニルグリコール酸2-(ジエチルアミノ)エチル;ベンジル酸2-(ジエチルアミノ)エチル;ベナクチジン;ダイアジル;2-ヒドロキシ-2,2-ジフェニル酢酸2-(ジエチルアミノ)エチル;ジアジル;ヒドロキシジフェニル酢酸2-(ジエチルアミノ)エチル;α-ヒドロキシ-α-フェニル-ベンゼン酢酸2-(ジエチルアミノ)エチル;α-ヒドロキシ-α-フェニルベンゼン酢酸2-(ジエチルアミノ)エチル;2-(ジエチルアミノ)エチル 2-ヒドロキシ-2,2-ジフェニルアセタート
英語名:
Benactyzine
英語别名:
Benactyzin;benactyzine;Benactyzine USP/EP/BP;Flamprop-methyl Impurity 8;Diethylaminoethyl benzilate;IVQOFBKHQCTVQV-UHFFFAOYSA-N;2-Diethylaminoethyl benzilate;Benzilic acid, 2-(diethylamino)ethyl ester;Benactyzine (base and/or unspecified salts);Diphenylglycolic acid 2-(diethylamino)ethyl ester
CBNumber:
CB0854797
化学式:
C20H25NO3
分子量:
327.42
MOL File:
302-40-9.mol

ベナクチジン 物理性質

融点 :
51°
沸点 :
465.31°C (rough estimate)
比重(密度) :
1.1392 (rough estimate)
屈折率 :
1.5614 (estimate)
貯蔵温度 :
2-8°C
酸解離定数(Pka):
11.31±0.29(Predicted)
NISTの化学物質情報:
Benactyzine(302-40-9)

安全性情報

主な危険性  T
Rフレーズ  23/24/25
Sフレーズ  36/37/39-45
有毒物質データの 302-40-9(Hazardous Substances Data)
毒性 human,TDLo,intramuscular,100ug/kg (0.1mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE,"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982.

ベナクチジン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

ベナクチジン MSDS


Benactyzine

ベナクチジン 化学特性,用途語,生産方法

効能

抗不安薬, 気管支拡張薬

Originator

Suavitil,Merck Sharp and Dohme,US,1957

Manufacturing Process

114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part of metallic sodium were placed in a flask attached to a total-reflux variable take-off fractionating column. The pressure was reduced to 100 mm and heat was applied by an oil bath the temperature of which was slowly raised to 90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C). When the distillation of the ethanol became slow, the bath temperature was raised to 120°C. When the vapor temperature indicated distillation of the amino alcohol the take off valve was closed and the mixture was refluxed for one hour. At the end of this period the vapor temperature had dropped and two more parts of ethanol were distilled, The remaining aminoalcohol was slowly distilled for three hours. The pressure was then reduced to 20 mm and the remainder of the aminoalcohol distilled at 66°C. During the reaction the color of the solution changed from yellow to deep red. The residue was dissolved in 500 parts of ether, washed once with dilute brine, and three times with water, dried over sodium sulfate and finally dried over calcium sulfate. 500 parts of a saturated solution of HCl in absolute ether was added and the resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a slight excess and the precipitate again filtered. The combined precipitates were washed with cold acetone. The 106 parts of product was purified by recrystallization from acetone as fine white crystals which melt at 177°- 178°C.

Therapeutic Function

Tranquilizer; Anticholinergic

ベナクチジン 上流と下流の製品情報

原材料

準備製品


ベナクチジン 生産企業

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302-40-9(ベナクチジン)キーワード:


  • 302-40-9
  • 2-diethylaminoethyl 2-hydroxy-2,2-diphenyl-acetate
  • benactyzine
  • Benactyzine (base and/or unspecified salts)
  • 2-Diethylaminoethyl benzilate
  • Benzilic acid, 2-(diethylamino)ethyl ester
  • Diethylaminoethyl benzilate
  • Benactyzin
  • Diphenylglycolic acid 2-(diethylamino)ethyl ester
  • α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl
  • α-Hydroxy-α-phenylbenzeneacetic acid 2-(diethylamino)ethyl ester
  • 2-diethylaminoethyl 2-hydroxy-2,2-di(phenyl)ethanoate
  • 2-hydroxy-2,2-di(phenyl)acetic acid 2-diethylaminoethyl ester
  • Benactyzine USP/EP/BP
  • Benzeneacetic acid, α-hydroxy-α-phenyl-, 2-(diethylamino)ethyl ester
  • IVQOFBKHQCTVQV-UHFFFAOYSA-N
  • Flamprop-methyl Impurity 8
  • ジフェニルグリコール酸ジエチルアミノエチル
  • ジフェニルグリコール酸2-(ジエチルアミノ)エチル
  • ベンジル酸2-(ジエチルアミノ)エチル
  • ベナクチジン
  • ダイアジル
  • 2-ヒドロキシ-2,2-ジフェニル酢酸2-(ジエチルアミノ)エチル
  • ジアジル
  • ヒドロキシジフェニル酢酸2-(ジエチルアミノ)エチル
  • α-ヒドロキシ-α-フェニル-ベンゼン酢酸2-(ジエチルアミノ)エチル
  • α-ヒドロキシ-α-フェニルベンゼン酢酸2-(ジエチルアミノ)エチル
  • 2-(ジエチルアミノ)エチル 2-ヒドロキシ-2,2-ジフェニルアセタート
  • ジフェニルメタン系抗不安薬
  • 抗コリン作動薬
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