αステアロイルω（ステアロイルオキシ）ポリ（オキシエチレン） 化学特性,用途語,生産方法
定義
本品は、ステアリン酸(*)とPEG-150(*)のジエステルであり、次の化学式で表される。
n：平均150
参照表示名称：ステアリン酸, ＰＥＧ－１５０
化粧品の成分用途
可溶化剤、親水性増粘剤、乳化剤、洗浄剤
化学的特性
A soft, off-white solid. PH of 10% dispersion 7.26, saponification number variable. Soluble in chlorinated solvents, light esters, and acetone; slightly soluble in alcohols, insoluble in glycols, hydrocarbons, and vegetable oils. Combustible.
使用
POLY(ETHYLENE GLYCOL) (N) DISTEARATE is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry.
定義
Distearate ester of polyglycol.
調製方法
Polyethylene glycol distearate is prepared by the direct reaction of
fatty acids, particularly stearic acid, with ethylene oxide.
応用例（製薬）
Polyethylene glycol distearate is generally used as emulsifiers in oil-inwater-
type creams and lotions. Its hydrophilicity or lipophilicity
depends on the number of ethylene oxide units present: the larger
the number, the greater the hydrophilic properties. Polyoxyl 40
stearate has been used as an emulsifying agent in intravenous
infusions.
Polyoxyethylene stearates are particularly useful as emulsifying
agents when astringent salts or other strong electrolytes are present.
It can also be blended with other surfactants to obtain any
hydrophilic–lipophilic balance for lotions or ointment formulations.
安全性プロファイル
Poison by intravenous
route. When heated to decomposition it
emits acrid smoke and irritating fumes. See
also POLYETHYLENE GLYCOL.
安全性
Although Polyethylene glycol distearate is primarily used as emulsifying
agents in topical pharmaceutical formulations, certain materials,
particularly polyoxyl 40 stearate, have also been used in
intravenous injections and oral preparations.
Polyethylene glycol distearate has been tested extensively for
toxicity in animals(8–13) and are widely used in pharmaceutical formulations and cosmetics. It is generally regarded as
essentially nontoxic and nonirritant materials.
Polyoxyl 8 stearate
(hamster, oral): 27 g/kg
(rat, oral): 64 g/kg
Polyoxyl 20 stearate
(mouse, IP): 0.2 g/kg
(mouse, IV): 0.87 g/kg
貯蔵
Polyoxyethylene stearates are generally stable in the presence of electrolytes and weak acids or bases. Strong acids and bases can cause gradual hydrolysis and saponification.
The bulk material should be stored in a well-closed container, in a dry place, at room temperature.
不和合性
Polyethylene glycol distearate is unstable in hot alkaline solutions
owing to hydrolysis, and will also saponify with strong acids or
bases. Discoloration or precipitation can occur with salicylates,
phenolic substances, iodine salts, and salts of bismuth, silver, and
tannins.Complex formation with preservatives may also
occur.The antimicrobial activity of some materials such as
bacitracin, chloramphenicol, phenoxymethylpenicillin, sodium
penicillin, and tetracycline may be reduced in the presence of
polyoxyethylene stearate concentrations greater than 5% w/w.
規制状況(Regulatory Status)
Included in the FDA Inactive Ingredients Database (dental
solutions; IV injections; ophthalmic preparations; oral capsules
and tablets; otic suspensions; topical creams, emulsions, lotions,
ointments, and solutions; and vaginal preparations). Included in
nonparenteral medicines licensed in the UK. Included in the
Canadian List of Acceptable Non-medicinal Ingredients.
αステアロイルω（ステアロイルオキシ）ポリ（オキシエチレン） 上流と下流の製品情報
原材料
準備製品