メトキシメチルクロリド 化学特性,用途語,生産方法
外観
無色～黄褐色, 澄明の液体
溶解性
水に不溶。
用途
メトキシメチル化剤、塩化メチル化剤、イオン交換膜修飾剤医薬?農薬中間体
化学的特性
Chloromethyl methyl ether is a volatile, highly
flammable, corrosive liquid with an ethereal odor.
使用
Chloromethyl methyl ether (CMME) is usedas a methylating agent in the synthesis ofchloromethylated compounds.
危険性
Flammable, dangerous fire and explosion
risk. Toxic by ingestion and inhalation. TLV: Suspected human carcinogen.
健康ハザード
The acute toxicity of chloromethyl methyl ether is moderate to high. Inhalation of the vapor is severely irritating to the eyes, skin, nose, and respiratory tract, and causes sore throat, fever, chills, and difficulty breathing. Exposure to high concentrations can lead to delayed pulmonary edema, which can be fatal. Eye or skin contact with the liquid can result in severe and painful burns. Ingestion of this substance may lead to severe burns of the mouth and stomach and can be fatal. Chloromethyl methyl ether is regulated by OSHA as a carcinogen (29 CFR 1910.1006) and is listed in IARC Group 1 ("carcinogenic to humans"). This substance is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Note also that some commercial samples of chloromethyl methyl ether contain up to 7% of highly carcinogenic bis(chloromethyl) ether. Hydrolysis of chloromethyl methyl ether produces HCl and formaldehyde, which can recombine to form bis(chloromethyl) ether. No information is available on the reproductive and developmental toxicity of chloromethyl methyl ether. Odor does not provide adequate warning of the harmful presence of this carcinogenic substance.
火災危険
Chloromethyl methyl ether is highly flammable. Fires involving this substance should be extinguished with carbon dioxide or dry chemical extinguishers.
燃焼性と爆発性
Chloromethyl methyl ether is highly flammable. Fires involving this substance should be extinguished with carbon dioxide or dry chemical extinguishers.
安全性プロファイル
Confirmed human
carcinogen with experimental carcinogenic,
tumorigenic, and neoplastigenic data. Poison
by inhalation. Moderately toxic by ingestion.
Human mutation data reported. A very
dangerous fire hazard when exposed to heat
or flame. To fight fire, use alcohol foam,water, CO2, or dry chemical. Reaction with
dvalent metals forms a very reactive
product. When heated to decomposition it
emits toxic fumes of Cl-. See also ETHERS
and CHLORINATED
HYDROCARBONS, ALIPHATIC.
職業ばく露
Chloromethyl. methyl ether is a highly
reactive methylating agent and is used in the chemical
industry for synthesis of organic chemicals. Most industrial
operations are carried out in closed process vessels so that
exposure is minimized.
発がん性
Technical-grade chloromethyl methyl ether (CMME) are known to be human carcinogens based on sufficient evidence of carcinogenicity from studies in humans.
貯蔵
work with this substance should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and splash goggles should be worn at all times to prevent skin and eye contact. Chloromethyl methyl ether is also highly flammable and should be used only in areas free of ignition sources; quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers in secondary containers.
輸送方法
UN1239 Methyl chloromethyl ether, Hazard
class: 6.1; Labels: 6.1-Poison Inhalation Hazard,
3-Flammable liquid, Inhalation Hazard Zone A. PGI.
純化方法
If suspect (check IR), shake it with saturated aqueous CaCl2 solution, dry over CaCl2 and fractionally distil taking middle fraction. [Marvel & Porter Org Synth Coll Vol I 377 1941, Beilstein 1 H 580, 1 I 304, 1 II 645, 1 III 2587, 1 IV 3046.] VERY TOXIC and CARCINOGENIC.
不和合性
May form explosive mixture with air.
May be able to form unstable and explosive peroxides on
contact with oxygen. Contact with (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine,
fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides. Decomposes on contact with water,
forming hydrochloric acid and formaldehyde. Attacks various metals in presence of water.
廃棄物の処理
Incineration, preferably after
mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove
the halo acids produced.
メトキシメチルクロリド 上流と下流の製品情報
原材料
準備製品
2-クロロメチルチオフェン
N,N-ジメチル-3-ニトロアニリン
4-(メトキシメトキシ)安息香酸
2,4-ビス(クロロメチル)-1,3,5-トリメチルベンゼン
5-メトキシ-3-オキソ吉草酸メチル
1,2,3,4,5-ペンタメチル-6-(クロロメチル)ベンゼン
3-クロロメチル-5-ニトロサリチルアルデヒド
(R)-2,2'-ビス(メトキシメトキシ)-1,1'-ビナフチル
4-CHLOROMETHYLPHENYLACETIC ACID METHYL ESTER
4-イソプロピルベンジル クロリド
メトキシメチルトリメチルシラン
1,13-ジブロモトリデカン
メトキシメチル(ジフェニル)ホスフィンオキシド