コスツノリド

コスツノリド 価格 もっと(10)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01CHDASB-00003825	コスツノリド Costunolide	553-21-9	10mg	￥93200	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01CHDASB-00003825	コスツノリド Costunolide	553-21-9	25mg	￥104000	2024-03-01	購入
東京化成工業	C2921	コスツノリド >95.0%(HPLC) Costunolide >95.0%(HPLC)	553-21-9	25mg	￥19800	2024-03-01	購入
東京化成工業	C2921	コスツノリド >95.0%(HPLC) Costunolide >95.0%(HPLC)	553-21-9	100mg	￥58100	2024-03-01	購入
関東化学株式会社(KANTO)	49061-70	コスツノリド Costunolide	553-21-9	10mg	￥39000	2024-03-01	購入

コスツノリド 化学特性,用途語,生産方法

外観

白色～ほとんど白色粉末～結晶

説明

Costunolide is a germacranolide sesquiterpene lactone extracted from costus oil. With alantolactone and dehydrocostuslactone, it is a component of lactone mix used to elicit reactions in Compositae-sensitive patients. An erythema-multiform-like occupational contact dermatitis case occurred in a chemistry student after accidental exposure to costus oil (CJ Le Coz & JP Lepoittevin, unpublished results).

化学的特性

White crystalline powder, soluble in chloroform, derived from woodsy, Inula magnifica, Kerria japonica, Malachite.

使用

Costunolide is the oil extracted from Saussurea lappa is used in perfumery and in the Orient for all kinds of diseases.

定義

ChEBI: Costunolide is a germacranolide with anthelminthic, antiparasitic and antiviral activities. It has a role as an anthelminthic drug, an antiinfective agent, an antineoplastic agent, an antiparasitic agent, an antiviral drug and a metabolite. It is a germacranolide and a heterobicyclic compound.

一般的な説明

Costunolide has anti-ulcer and antipyretic properties. It inhibits the cellular proliferation of melanin, human lamin-B by farnesyl-protein transferase (FPTase) and protein tyrosine phosphatase 1B (hPTP1B). Costunolide has strong larvicidal activity against A.albopictus. It inhibits the expression of inducible nitric oxide synthase and DNA-binding activity of nuclear factor kappa B subunit (NF-κB). It might function as a natural herbicide.

生物活性

Inhibitor of human telomerase activity (IC 50 = 65 μ M in MCF-7 breast cancer cells). Suppresses proliferation and induces apoptosis in a variety of human tumor cell lines. Selectively blocks endothelial cell proliferation induced by VEGF. Inhibits expression of iNOS and IL-1 β and disrupts NF- κ B activation. Displays anti-inflammatory, antifungal and antiviral properties.

Biochem/physiol Actions

Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity.

接触アレルゲン

This germacranolide sesquiterpene lactone is extracted from costus oil. With alantolactone and dehydrocostunolide, it is a component of lactone mix used to elicit reactions in patients sensitive to Asteraceae-Compositae. An erythema-multiform-like occupational contact dermatitis case occurred in a chemical student after an accidental exposure to costus oil.

コスツノリド 上流と下流の製品情報

原材料

準備製品

コスツノリド 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Chongqing Zhihe Biopharmaceutical Co., Ltd.	+86-18580541567 +86-17782035140	sales@zhswyy.com	China	338	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Xi'an Kono chem co., Ltd.,	029-86107037 13289246953	info@konochemical.com	China	2995	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58

553-21-9(コスツノリド )キーワード:

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• 553-21-9
• (3AS,6E,10E,11AR)-3A,4,5,8,9,11A-HEXAHYDRO-6,10-DIMETHYL-3-METHYLENE-CYCLODECA[B]FURAN-2(3H)-ONE
• COSTUNOLIDE
• (e,e)-6-alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oicacidgamma-lactone
• germacra-1(10),4,11(13)-trien-12-oicacid,6-alpha-hydroxy-,gamma-lactone,(e,
• Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3- methylene-, [3aS-(3aR*,6E,10E,11aS*)]-
• CUSTUNOLIDE
• Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-
• hexahydro-6,10-dimethyl-3-methylene-,(3aS,6E,10E,11aR)-
• (3aS,6E,10E)-3aβ,4,5,8,9,11aβ-Hexahydro-6,10-dimethyl-3-methylenecyclodeca[b]furan-2(3H)-one
• (3aS,6E,10E)-3-Methylene-6,10-dimethyl-2,3,3aβ,4,5,8,9,11aα-octahydrocyclodeca[b]furan-2-one
• Costulide
• (3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one
• NSC 106404
• Costunolide, froM Auckiandialappa Decne.
• (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3,3a,4,5,8,9-hexahydrocyclodeca[b]furan-2(11aH)-one
• Costunolide, >=98%
• Costundide 553-21-9
• Costunolide (NSC-106404)
• Costunolide, 98%, from Saussurea costus (Falc.) Lipsch.
• Costunolide CRS
• Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)-
• Costunolide,(S)
• costunolid
• Costunlide
• COSTUNDIDE
• (3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one
• costunoide
• Cosinolactone
• (+)-コスツノリド
• (3aS,6E,10E)-3-メチレン-6,10-ジメチル-2,3,3aβ,4,5,8,9,11aβ-オクタヒドロシクロデカ[b]フラン-2-オン
• (1S,4E,8E,10R)-4,8-ジメチル-13-メチレン-11-オキサビシクロ[8.3.0]トリデカ-4,8-ジエン-12-オン
• (3aS,6E,10E)-3aβ,4,5,8,9,11aα-ヘキサヒドロ-6,10-ジメチル-3-メチレンシクロデカ[b]フラン-2(3H)-オン
• (3aS,6E,10E)-3aβ,4,5,8,9,11aβ-ヘキサヒドロ-6,10-ジメチル-3-メチレンシクロデカ[b]フラン-2(3H)-オン
• (3aS,6E,10E)-3-メチレン-6,10-ジメチル-2,3,3aβ,4,5,8,9,11aα-オクタヒドロシクロデカ[b]フラン-2-オン
• (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-ヘキサヒドロ-6,10-ジメチル-3-メチレンシクロデカ[b]フラン-2(3H)-オン
• コスツノリド
• (3aS,11aS)-6,10-ジメチル-3-メチリデン-2H,3H,3aH,4H,5H,8H,9H,11aH-シクロデカ[b]フラン-2-オン
• (6E,10E)-3-メチレン-6,10-ジメチル-3aβ,4,5,8,9,11aα-ヘキサヒドロシクロデカ[b]フラン-2(3H)-オン