トリアムシノロン 化学特性,用途語,生産方法
解説
トリアムシノロンは，副腎皮質ホルモンに含まれるグルココルチコイドから誘導，合成されたステロイドである。力価ではデキサメサゾンにやや劣るが，強力な抗炎症作用をもち，他の作用や副作用もデキサメサゾンと同様である。臨床的にも同様に慢性関節リウマチ，リウマチ熱，膠原病，アレルギー性疾患などに広く用いられる。ブリタニカ国際大百科事典 小項目事典 ブリタニカ
効能
喘息治療薬, 抗炎症薬, 抗リウマチ薬, グルココルチコイド受容体作動薬
商品名
レダコート (アルフレッサファーマ)
説明
A natural extension of corticoid research involved examination of compounds containing both a 9α-fluoro group
and a double bond between positions 1 and 2. Triamcinolone (9-fluoro-11β, 16α, 17, 21-tetrahydroxypregna-
1,4-diene-3,20-dione), introduced in 1958, combines the structural features of a ?1
-corticoid and a 9α-fluoro
corticoid. As mentioned previously, the 9α-fluoro group increases the anti-inflammatory potency,
but it also markedly increases the mineralocorticoid potency. This is undesirable if the drug is to be used
internally for the treatment of rheumatoid arthritis. By inserting a 16α-hydroxy group into the molecule, one can
decrease the mineralocorticoid activity.
化学的特性
White, crystalline powder. Insoluble in water; slightly soluble in usual
organic solvents; soluble in dimethylformamide.
使用
Triamcinolone is a glucocorticoid. Triamcinolone is used as an antiasthmatic (inhalant); antiallergic (nasal).
定義
ChEBI: A C21-steroid hormone that is 1,4-pregnadiene-3,20-dione carrying four hydroxy substituents at positions 11beta, 16alpha, 17alpha and 21 as well as a fluoro substituent at position 9.
sed in the form of its 16,17-acetonide to treat various skin infections.
適応症
Intralesional bleomycin, a cytotoxic drug that inhibits DNA synthesis, is effective
for all varieties of recalcitrant warts. Various concentrations of the drug have
been used, although the total dose must be carefully tracked over time to avoid
potential systemic toxicity.
臨床応用
Triamcinolone to be used topically is generally dispensed as its more potent and lipophilic acetonide, a
16α,17α-methylenedioxy cyclic ketal or isopropylidene derivative. It is effective in the treatment of psoriasis and other corticoid-sensitive dermatologic
conditions. Topically, triamcinolone acetonide is a more potent derivative of triamcinolone and is approximately
eight times more active than prednisolone.
副作用
Even though triamcinolone has an apparently decreased tendency to cause salt and water retention and edema
and may induce sodium and water diuresis, it causes other unwanted side effects, including anorexia, weight
loss, muscle weakness, leg cramps, nausea, dizziness, and a general toxic feeling.
安全性プロファイル
Poison by subcutaneous route.An experimental teratogen. Other experimentalreproductive effects. Human mutation data reported.When heated to decomposition it emits toxic fumes of F??.An anti-inflammatory and antiallergic agent.
トリアムシノロン 上流と下流の製品情報
原材料
準備製品