2-ニトロ-1-ナフトール
2-ニトロ-1-ナフトール 物理性質
- 融点 :
- 123-125 °C (lit.)
- 沸点 :
- 324.41°C (rough estimate)
- 比重(密度) :
- 1.3175 (rough estimate)
- 屈折率 :
- 1.5400 (estimate)
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 酸解離定数(Pka):
- 6.13±0.50(Predicted)
- 外見 :
- Powder
- InChI:
- InChI=1S/C10H7NO3/c12-10-8-4-2-1-3-7(8)5-6-9(10)11(13)14/h1-6,12H
- InChIKey:
- MUCCHGOWMZTLHK-UHFFFAOYSA-N
- SMILES:
- C1(O)=C2C(C=CC=C2)=CC=C1[N+]([O-])=O
- CAS データベース:
- 607-24-9(CAS DataBase Reference)
- NISTの化学物質情報:
- 2-Nitro-1-naphthol(607-24-9)
2-ニトロ-1-ナフトール 価格
もっと(6)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQB-6346 |
2-ニトロ-1-ナフトール
2-Nitro-1-naphthol |
607-24-9 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQB-6346 |
2-ニトロ-1-ナフトール
2-Nitro-1-naphthol |
607-24-9 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQB-6346 |
2-Nitro-1-naphthol |
607-24-9 |
25g |
￥30000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQB-6346 |
2-Nitro-1-naphthol |
607-24-9 |
100g |
￥90000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
161152 |
2-ニトロ-1-ナフトール 95%
2-Nitro-1-naphthol 95% |
607-24-9 |
5g |
￥27900 |
2024-03-01 |
購入 |
2-ニトロ-1-ナフトール 化学特性,用途語,生産方法
説明
2-Nitro-1-naphthol is an important organic compound with anti-inflammatory properties used as an analytical method for measuring albumin concentration and as an enzyme-labelled substrate in electrochemical immunoassays. The substance reacts with albumin to form a coloured complex which can be detected spectrophotometrically. It is also used as a model system for the study of inflammatory diseases and inhibits p38 kinase activity. In addition, a derivative of 2-Nitro-1-naphthol (4-nitro-1-naphthol) can be used to prepare chromogenic substrates for neutral or slightly acidic hydrolases.
化学的特性
yellow-green to ochre-brown powder and/or chunks
使用
2-Nitro-1-naphthol was employed as substrate for use in an amperometric 3-electrode system for the determination of alkaline phosphatase, the enzyme label most commonly used in electrochemical immunoassays. It was also used in the preparation of:
- di-(2-nitro-1-naphthyl) hydrogen phosphate
- 1-(2′-methyl-3′-indenyl)-2-naphthylamine and -2-naphthol (axially chiral ligands)
主な応用
2-Nitro-1-naphthol is commonly used as an intermediate in organic synthesis. It is a derivative of 1-nitro-2-naphthol and 4-nitro-1-naphthol. 1-Nitro-2-naphthol has been found to be a potent inhibitor of enzyme-dependent activation of acetyl-CoA, while 4-nitro-1-naphthol facilitates the preparation of chromogenic substrates for neutral or slightly acidic hydrolases
[1-2].
純化方法
Crystallise the naphthol (repeatedly) from EtOH. [Beilstein 6 H 615, 6 III 2938, 6 IV 4236.]
参考文献
[1] JIZHENG DANG . Chromogenic substrate from 4-nitro-1-naphthol for hydrolytic enzyme of neutral or slightly acidic optimum pH: 4-Nitro-1-naphthyl-β-d-galactopyranoside as an example[J]. Bioorganic & Medicinal Chemistry Letters, 2013. DOI:10.1016/j.bmcl.2012.11.120.
[2] ATSUKO SHINOHARA. Inhibition of acetyl-coenzyme A dependent activation of N-hydroxyarylamines by phenolic compounds, pentachlorophenol and 1-nitro-2-naphthol[J]. Chemico-Biological Interactions, 1986. DOI:10.1016/0009-2797(86)90058-X.
2-ニトロ-1-ナフトール 上流と下流の製品情報
原材料
準備製品
2-ニトロ-1-ナフトール 生産企業
Global( 164)Suppliers
2-ニトロ-1-ナフトール スペクトルデータ(1HNMR、13CNMR、IR1、IR2、MS、Raman)
607-24-9(2-ニトロ-1-ナフトール)キーワード:
- 607-24-9
- 2-NITRO-1-NAPHTHOL
- 2-Nitro-1-Napthol
- 2-Nitronaphth-1-ol
- 2-Nitro-2-naphthol
- 1-Naphthalenol, 2-nitro-
- 2-Nitronaphthalen-1-ol
- 2-Nitro-1-naphthol,98%
- 2-Nitro-1-naphthol 95%
- 2-ニトロ-1-ナフトール