RIPA-56
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- CAS番号.
- 1956370-21-0
- 化学名:
- 别名:
- 英語名:
- RIPA-56
- 英語别名:
- RIPA-56;RIPA56; RIPA 56;RIPA-56 >=98% (HPLC);N-Benzyl-N-hydroxy-2,2-dimethylbutanamide;Butanamide, N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-;RIPA-56,inhibit,Receptor-interacting protein kinases,RIP kinase,RIPK,Inhibitor,RIPA 56,RIPA56
- CBNumber:
- CB33167633
- 化学式:
- C13H19NO2
- 分子量:
- 221.3
- MOL File:
- 1956370-21-0.mol
- MSDS File:
- SDS
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RIPA-56 物理性質
- 沸点 :
- 346.0±35.0 °C(Predicted)
- 比重(密度) :
- 1.070±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- -20°C
- 溶解性:
- DMSO (最大 50mg/ml) またはエタノール (最大 50mg/ml) に可溶
- 外見 :
- 個体
- 酸解離定数(Pka):
- 9.42±0.50(Predicted)
- 色:
- 白い
- 安定性：:
- DMSO溶液またはエタノール溶液で-20°Cで最大3か月保存できます。
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
RIPA-56 価格
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製品番号 |
製品説明 |
CAS番号 |
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更新時間 |
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RIPA-56 化学特性,用途語,生産方法
Biochem/physiol Actions
RIPA-56 is a metabolically stable type III kinase inhibitor that targets receptor-interacting protein 1 kinase (RIP1; RIPK1) in a highly potent and selective manner (RIP1 IC50 = 13 nM) by locking RIP1 in its inactive form, exhibiting no inhibitory potency toward RIP3, IDO or a panel of multiple kinases (tested at 10, 200, and 5 μM, respectively). RIPA-56 protects against TNFα-induced necroptosis (necrosis) upon apoptosis/NF-κB pathway blockage (EC50?= 27 nM/murine L929 and 28 nM/human HT-29 cells) in cultures as well as TNFα-induced mortality and multiorgan damage in a murine model of systemic inflammatory response syndrome (SIRS) in vivo (100% survival rate with 3 mg/kg/12 h or single 6 mg/kg i.p.) with good pharmacokinetics and bioavailability (F post 10 mg/kg p.o. or i.p. dosing = 22% and 100%, respectively, of 2 mg/kg i.v.). Long-term daily RIPA-56 supplementation (150 or 300 mg/kg in chow) is reported to prevent aging-associated deterioration of the male reproductive system in mice.
RIPA-56 上流と下流の製品情報
原材料
準備製品
RIPA-56 生産企業
Global( 55)Suppliers
1956370-21-0()キーワード:
- 1956370-21-0
- RIPA-56
- RIPA56; RIPA 56
- Butanamide, N-hydroxy-2,2-dimethyl-N-(phenylmethyl)-
- RIPA-56 >=98% (HPLC)
- N-Benzyl-N-hydroxy-2,2-dimethylbutanamide
- RIPA-56,inhibit,Receptor-interacting protein kinases,RIP kinase,RIPK,Inhibitor,RIPA 56,RIPA56