アンタラルミン塩酸塩 化学特性,用途語,生産方法
説明
Corticotropin-
releasing hormone (CRH) secreted from the hypothalamus is the major regulator of pituitary corticotropin-
release and consequent glucocorticoid secretion. Antalarmin is a selective, nonpeptide antagonist of the CRH receptor 1 (K
i = 1 nM) that, consequently, reduces the release of corticotropin in response to chronic stress. Through its antagonism of central CRH signaling, antalarmin can reduce endocrinological, cardiovascular, and behavioral responses to stressful stimuli. It has also been shown to reduce dose escalation in cocaine-
addicted rats, to produce anti-
inflammatory effects in arthritis models, and to suppress stress-
induced gastric ulceration related to irritable bowel syndrome.
使用
Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.
生物活性
Non-peptide corticotropin-releasing hormone receptor 1 (CRF 1 ) antagonist (K i = 1 nM). Suppresses CRF-induced ACTH secretion. Blocks CRF- and novelty-induced anxiety-like behavior in animal models of anxiety.
アンタラルミン塩酸塩 上流と下流の製品情報
原材料
準備製品