イソキセパク
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- CAS番号.
- 55453-87-7
- 化学名:
- イソキセパク
- 别名:
- イソキセパク;イソキセパック;6,11-ジヒドロ-11-オキソジベンゾ[b,e]オキセピン-2-酢酸;11-オキソ-6,11-ジヒドロジベンゾ[b,e]オキセピン-2-酢酸;2-(11-オキソ-6,11-ジヒドロジベンゾ[b,e]オキセピン-2-イル)酢酸;6,11-ジヒドロ11-オキソジベンズ〔b.E〕オペピン2酢酸;6H-11-オキソジベンゾ[b,e]オキセピン-2-酢酸;2-{2-オキソ-9-オキサトリシクロ[9.4.0.03,8]ペンタデカ-1(15),3,5,7,11,13-ヘキサエン-5-イル}酢酸
- 英語名:
- Isoxepac
- 英語别名:
- 2-(11-Oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid;Olapatadine;6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID;6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid;artil;hp549;ND4-B2;isoxepac;P-720549;NSC 300907
- CBNumber:
- CB3466254
- 化学式:
- C16H12O4
- 分子量:
- 268.26
- MOL File:
- 55453-87-7.mol
- MSDS File:
- SDS
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イソキセパク 物理性質
- 融点 :
- 130-132°C
- 沸点 :
- 528.2±50.0 °C(Predicted)
- 比重(密度) :
- 1.39 g/cm3
- 貯蔵温度 :
- Sealed in dry,Room Temperature
- 溶解性:
- soluble in Methanol
- 外見 :
- Solid
- 酸解離定数(Pka):
- 4.24±0.10(Predicted)
- 色:
- White to Light yellow to Light orange
- Merck :
- 14,5237
- InChIKey:
- QFGMXJOBTNZHEL-UHFFFAOYSA-N
- CAS データベース:
- 55453-87-7(CAS DataBase Reference)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCI917700 |
イソキセパック
Isoxepac |
55453-87-7 |
1g |
¥26100 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCI917700 |
イソキセパック
Isoxepac |
55453-87-7 |
10g |
¥101200 |
2023-06-01 |
購入 |
東京化成工業
|
D4242 |
6,11-ジヒドロ-11-オキソジベンゾ[b,e]オキセピン-2-酢酸 >97.0%(HPLC)(T)
6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid
>97.0%(HPLC)(T) |
55453-87-7 |
1g |
¥3100 |
2024-03-01 |
購入 |
東京化成工業
|
D4242 |
6,11-ジヒドロ-11-オキソジベンゾ[b,e]オキセピン-2-酢酸 >97.0%(HPLC)(T)
6,11-Dihydro-11-oxodibenzo[b,e]oxepin-2-acetic Acid
>97.0%(HPLC)(T) |
55453-87-7 |
5g |
¥10400 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
PHR2539 |
Pharmaceutical Secondary Standard; Certified Reference Material
Olopatadine Related Compound C Pharmaceutical Secondary Standard; Certified Reference Material |
55453-87-7 |
50MG |
¥82900 |
2024-03-01 |
購入 |
イソキセパク 化学特性,用途語,生産方法
外観
白色~うすい黄色~うすい黄赤色粉末~結晶
効能
抗炎症薬
化学的特性
Beige Solid
使用
Isoxepac is a non-steroidal anti-inflammatory with analgesic and antipyretic activity. It is more slowly absorbed and eliminated in the rat and rabbit after oral dosing than in the dog, rhesus monkey and man.It can be used to treat allergic rhinitis, urticaria, and skin diseases with itching symptoms.
製造方法
Isoxic acid is an important intermediate in the synthesis of the new preferred anti-allergic drug, olopatadine hydrochloride, preparation method of isoxepac:
(1) condensation: prepare p-hydroxyphenylaceticacid 8-12 part, phthalide 6-12 part, sodium methylate 8-12 part by weight; Dissolve with DMAC and to add said sodium methylate behind said p-hydroxyphenylaceticacid and the phthalide; Be that 0.1-10Pa is heated to 80-170 ℃ of reaction 3-10h at pressure then; Regulate the pH value to 1-5,4-(2-carboxyl benzyloxy) toluylic acid is separated out in crystallization;
(2) cyclization: with Glacial acetic acid min. 99.5 dissolving step (1) gained 4-(2-carboxyl benzyloxy) toluylic acid, adding 3-52 weight part polyphosphoric acid again, is that 0.1-10Pa is heated to 30-100 ℃ of reaction 3-12h at pressure, and crystallisation by cooling gets the Isoxepac bullion then;
(3) purify: behind the said Isoxepac bullion of acetic acid ethyl dissolution, refining decolouring gets the Isoxepac product.
https://patents.google.com/patent/CN102838582A/en
定義
ChEBI: Isoxepac is a dibenzooxazepine.
brand name
Artil(Hoechst-Roussel)
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イソキセパク 上流と下流の製品情報
原材料
準備製品
イソキセパク 生産企業
Global( 375)Suppliers
55453-87-7(イソキセパク)キーワード:
- 55453-87-7
- 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic acid (Olopatadine)
- Olopatadine Related Compound C (35 mg) ((11-oxo-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid)
- ND4-B2
- artil
- isoxepac
- (11-OXO-6,11-DIHYDRODIBENZO[B,E]OXEPIN-2-YL)ACETIC ACID
- 11-Oxo-6,11-dihydrodibenz[b,e]oxepin-2-acetic Acid
- NSC 300907
- Isoxepac-d6
- Olopatadine Related CoMpund C
- Olopatadine Related CoMpound C
- Olopatadine USP RC C
- e)oxepin-2-aceticacid,6,11-dihydro-11-oxo-dibenz(
- hp549
- DIBENZ[B,E]OXEPIN-2-ACETIC ACID, 6,11-DIOHYDRO-11-OXO
- 6,11-Hydro-11-Oxo-Dibenz[B,E]Oxepin-2-Acetic Acid
- 11-Oxo-6,11-Dihydrobenz(b,e)oxepin-2-Acetic Acid (Isoxepac)
- Isoxepac (Dibenz[b,e]oxepin-2-acetic acid, 6,11-dihydro-11-oxo)
- 6,11-Dihydro-11-oxo-dibenz[b,e]oxepin-2-acetic
- 6,11-Dihydro-11-oxodibenz[b,e]oxepine-2-acetic acid
- P-720549
- 6,11-dihydro-11-oxodibenz[b,e]opepin-2-acetic acid
- 2-(11-keto-6H-benzo[c][2]benzoxepin-2-yl)acetic acid
- 2-(11-oxo-6H-benzo[c][2]benzoxepin-2-yl)acetic acid
- 2-(11-oxo-6H-benzo[c][2]benzoxepin-2-yl)ethanoic acid
- 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid (Isoxepac)
- 6,11-DIHYDRO-11-OXO-DIBENZ[B,E]OXEPIN-2-ACETIC ACID(FOR OLOPATADINE)
- Olotatadine related compound C
- Olopatadine USP Related Compound C
- e]oxepin-2-acetic acid
- イソキセパク
- イソキセパック
- 6,11-ジヒドロ-11-オキソジベンゾ[b,e]オキセピン-2-酢酸
- 11-オキソ-6,11-ジヒドロジベンゾ[b,e]オキセピン-2-酢酸
- 2-(11-オキソ-6,11-ジヒドロジベンゾ[b,e]オキセピン-2-イル)酢酸
- 6,11-ジヒドロ11-オキソジベンズ〔b.E〕オペピン2酢酸
- 6H-11-オキソジベンゾ[b,e]オキセピン-2-酢酸
- 2-{2-オキソ-9-オキサトリシクロ[9.4.0.03,8]ペンタデカ-1(15),3,5,7,11,13-ヘキサエン-5-イル}酢酸