クロロプロカイン

クロロプロカイン 化学構造式
133-16-4
CAS番号.
133-16-4
化学名:
クロロプロカイン
别名:
クロロプロカイン;4-アミノ-2-クロロ安息香酸2-(ジエチルアミノ)エチル;2-(ジエチルアミノ)エチル 4-アミノ-2-クロロベンゾアート;2-(ジエチルアミノ)エチル=4-アミノ-2-クロロベンゾアート
英語名:
CHLOROPROCAINE
英語别名:
C07877;Halestyn;Piocaine;nescaine;nesacaine;Chlorprocaine;Chloroprocain;CHLOROPROCAINE;2-Chloroprocaine;SGVQMKDQDTWFEM-UHFFFAOYSA-N
CBNumber:
CB4183345
化学式:
C13H19ClN2O2
分子量:
270.76
MOL File:
133-16-4.mol

クロロプロカイン 物理性質

融点 :
42°C
沸点 :
402.6±35.0 °C(Predicted)
比重(密度) :
1.2020 (rough estimate)
屈折率 :
1.5270 (estimate)
酸解離定数(Pka):
9.14±0.25(Predicted)

安全性情報

有毒物質データの 133-16-4(Hazardous Substances Data)

クロロプロカイン 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

クロロプロカイン 化学特性,用途語,生産方法

効能

局所麻酔薬

説明

Chloroprocaine (N,N′-diethylaminoethyl 4-amino-2-chlorobenzoate) is a very short-acting, amino ester-type local anesthetic used to provide regional anesthesia by infiltration as well as by peripheral and central nerve block, including lumbar and caudal epidural blocks. The presence of a chlorine atom ortho to the carbonyl of the ester function increases its rate of hydrolysis by plasma cholinesterase at least threefold compared to procaine and benzocaine. Thus, chloroprocaine may be used in maternal and neonatal patients with minimal placental passage of chloroprocaine. The lower plasma cholinesterase activity in the maternal epidural space must still have sufficient activity for degrading chloroprocaine and, thus, not allowing it to cross the placenta barrier. Like PABA, the hydrolysis product of chloroprocaine, 4-amino-2-chlorobenzoic acid, also inhibits the action of sulfonamides. Therefore, its use with sulfonamides should be avoided.

使用

Chloroprocaine is an ester that is metabolised rapidly by ester hydrolysis, so its duration of action is short and potential for cardiac toxicity relatively low. It can be used as a preservative-free solution for spinal anaesthesia for surgical procedures up to 40 min in duration.

定義

ChEBI: Procaine in which one of the hydrogens ortho- to the carboxylic acid group is substituted by chlorine. It is used as its monohydrochloride salt as a local anaesthetic, particularly for oral surgery. It has the advantage over lidocaine of const icting blood vessels, so reducing bleeding.

生物学の機能

Chloroprocaine hydrochloride (Nesacaine) is obtained from addition of a chlorine atom to procaine, which results in a compound of greater potency and less toxicity than procaine itself. This local anesthetic is hydrolyzed very rapidly by cholinesterase and therefore has a short plasma half-life. Because it is broken down rapidly, chloroprocaine is commonly used in obstetrics. It is believed that the small amount that might get to the fetus continues to be rapidly hydrolyzed, so there may be no residual effects on the neonate.

一般的な説明

The 2 chloride substitution on the aromatic ring of chloroprocaineis an electron-withdrawing functional group. Thus, itpulls the electron density from the carbonyl carbon into thering. The carbonyl carbon is now a stronger electrophile andmore susceptible to ester hydrolysis. Therefore, chloroprocainehas a more rapid metabolism than procaine. The in vitroplasma half-life is approximately 25 seconds. The 2-chloro-4-aminobenzoic acid metabolite precludes this from being usedin patients allergic to PABA. The very short duration of actionmeans that this drug can be used in large doses for conductionblock (with rapid onset and short duration of action.).

臨床応用

Chloroprocaine is used for cutaneous or mucous membraneinfiltration for surgical procedures, epidural anesthesia(without preservatives) and for peripheral conduction block.

クロロプロカイン 上流と下流の製品情報

原材料

準備製品


クロロプロカイン 生産企業

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133-16-4(クロロプロカイン)キーワード:


  • 133-16-4
  • CHLOROPROCAINE
  • 2-DIETHYLAMINOETHYL 4-AMINO-2-CHLORO-BENZOATE
  • 2-Chloroprocaine
  • 4-amino-2-chloro-benzoicaci2-(diethylamino)ethylester
  • Benzoic acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl ester
  • Chloroprocain
  • Chlorprocaine
  • Halestyn
  • nesacaine
  • nescaine
  • Piocaine
  • CHLOROPROCAINE(2-CHLOROPROCAINE HYDROCHLORIDE)
  • C07877
  • SGVQMKDQDTWFEM-UHFFFAOYSA-N
  • クロロプロカイン
  • 4-アミノ-2-クロロ安息香酸2-(ジエチルアミノ)エチル
  • 2-(ジエチルアミノ)エチル 4-アミノ-2-クロロベンゾアート
  • 2-(ジエチルアミノ)エチル=4-アミノ-2-クロロベンゾアート
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