エニルコナゾール 化学特性,用途語,生産方法
外観
白色～うすい褐色, 結晶～粉末又は塊
溶解性
水0.18g/l(pH 7.620℃)。アセトン, ジクロロメタン,エタノール, メタノール, イソプロパノール, キシレン, トルエン, ベンゼン＞500,ヘキサン19(共にg/l 20℃)。エタノール及びアセトンに溶け、水に極めて溶けにくい。
用途
イマザリル試験用標準品。
用途
農薬(殺菌剤)
効能
抗真菌薬
農薬用途
殺菌剤
説明
Imazalil is an imidazole fungicide that inhibits ergosterol biosynthesis. Imazalil inhibits the growth of various fungi
in vitro including
P. italicum,
A. niger,
U. maydis,
B. alii, and
C. cucumerinum in a pH-dependent manner (MICs = 0.005-2 μg/ml at pH 7). It inhibits
S. cerevisiae, but not rat liver microsomal, cytochrome P450 enzymes (CYPs; IC
50s = 0.088 and 80 μM, respectively), as well as aromatase CYP19 from human placental microsomes (IC
50 = 0.34 μM). Imazalil activates the murine pregnane X receptor (PXR) in a concentration-dependent manner in a cell-based reporter assay. It increases hepatic CYP3A11 and CYP2B10 mRNA levels in mice when administered at a dose of 100 mg/kg. Imazalil also increases Ki-67-positive nuclei in liver sections and hepatic MCM2 mRNA levels, markers of cell proliferation, in mice when co-administered with the murine constitutive androstane receptor (mCAR) agonist TCPOBOP . Formulations containing imazalil have been used to control fungal infection in agriculture.
使用
Imazalil is a systemic fungicide with protective and curative
action. It is used for the control of a wide range of fungal diseases on fruit,
vegetables and ornamentals, powdery mildew on roses and storage
diseases of citrus fruit, pome fruit, bananas and seed potatoes. It is also
used as a seed dressing, for control of diseases of cereals (particularly
Fusarium and Helminthosporium spp.), and it is particularly active against
benzimidazole-resistant strains of plant-pathogenic fungi.
一般的な説明
Slightly yellow to brown solidified oil. Non-corrosive. Used as a fungicide.
空気と水の反応
Water soluble.
反応プロフィール
Imazalil is an imidazole derivative.
安全性プロファイル
Poison by ingestion and
intraperitoneal routes. Experimental
reproductive effects. A skin and eye irritant.
When heated to decomposition it emits
toxic fumes of Cland NOx.
代謝経路
Published information is available on the metabolism of imazalil in plants
and soils. The principal metabolite in plants and soils is 1-[2-(2,4-
dichlorophenyl)-2-hydroxyethyl]-1H-imidazole.
エニルコナゾール 上流と下流の製品情報
原材料
準備製品