A66
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- CAS番号.
- 1166227-08-2
- 化学名:
- 别名:
- 英語名:
- A66
- 英語别名:
- CS-435;A 66;A-66;A66 USP/EP/BP;A66 PI3K inhibitor A-66;A66, 98%, a potent and specific p110α inhibitor;Phosphoinositide 3-kinase,inhibit,PI3K,A66,Inhibitor,A-66,A 66;(2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide;(S)-N1-(2-(tert-Butyl)-4'-methyl-[4,5'-bithiazol]-2'-yl)pyrrolidine-1,2-dicarboxamide;(2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide;(2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
- CBNumber:
- CB42553771
- 化学式:
- C17H23N5O2S2
- 分子量:
- 393.53
- MOL File:
- 1166227-08-2.mol
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A66 物理性質
- 比重(密度) :
- 1.354
- 貯蔵温度 :
- Sealed in dry,Store in freezer, under -20°C
- 溶解性:
- insoluble in H2O; ≥19.7 mg/mL in DMSO; ≥2.63 mg/mL in EtOH with gentle warming
- 外見 :
- solid
- 酸解離定数(Pka):
- 6.27±0.70(Predicted)
- 色:
- Off-white to light yellow
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
絵表示(GHS) |
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注意喚起語 |
警告 |
危険有害性情報 |
コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
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P264, P270, P301+P312, P330, P501 |
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注意書き |
P280 |
保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。 |
P305+P351+P338 |
眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
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メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCA101100 |
A66 |
1166227-08-2 |
5mg |
¥30300 |
2023-06-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCA101100 |
A66 |
1166227-08-2 |
10mg |
¥49000 |
2023-06-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC5595 |
A66 |
1166227-08-2 |
10mg |
¥58000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC5595 |
A66 |
1166227-08-2 |
50mg |
¥245000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCA101100 |
A66 |
1166227-08-2 |
50mg |
¥208500 |
2023-06-01 |
購入 |
A66 化学特性,用途語,生産方法
説明
A-66 is a potent, selective inhibitor of the PI3K isoform p110α (IC
50 = 32 nM in a cell-free assay). It displays over 100-fold selectivity for p110α over other isoforms. A-66 is effective
in vivo, suppressing the growth of SK-OV-3 tumor xenografts in mice. It also impairs all measures of
in vivo insulin action in mice. A-66 partially suppresses B cell receptor-dependent Akt activation and proliferation.
酵素阻害剤
This potent and highly selective p110α inhibitor (FW = 393.53; CAS 1166227-08-2; Solubility: 79 mg/mL DMSO, 1 mg/mL H2O), also known as (2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1, 2-dicarboxamide, has a IC50 value of 32 nM for the wild-type phosphoinositide-3 kinase p110 α as well as oncogenic forms of p110α such as p110α E545K (IC50 = 43 nM) and p110α H1047R (IC50 = 43 nM). A66 inhibition also demonstrated that cancer-specific mutations in the iSH2 (inter-SH2) and nSH2 (N-terminal SH2) domains of p85α, the regulatory subunit of phosphatidylinositide 3-kinase (PI3K), show gain of function, inducing oncogenic cellular transformation, stimulating cellular proliferation, and enhancing PI3K signaling.
A66 上流と下流の製品情報
原材料
準備製品
A66 生産企業
Global( 113)Suppliers
1166227-08-2()キーワード:
- 1166227-08-2
- (2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
- (2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide
- (2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide A 66
- CS-435
- A66, 98%, a potent and specific p110α inhibitor
- (2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
- A 66;A-66
- 1,2-Pyrrolidinedicarboxamide, N1-[2-(1,1-dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-, (2S)-
- A66 USP/EP/BP
- A66 PI3K inhibitor A-66
- Phosphoinositide 3-kinase,inhibit,PI3K,A66,Inhibitor,A-66,A 66
- (S)-N1-(2-(tert-Butyl)-4'-methyl-[4,5'-bithiazol]-2'-yl)pyrrolidine-1,2-dicarboxamide