2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 物理性質
- 融点 :
- 254-256°C
- 沸点 :
- 520.9±45.0 °C(Predicted)
- 比重(密度) :
- 1.570±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- ジクロロメタン（微量、加熱）、DMSO（微量）
- 酸解離定数(Pka):
- 10.63±0.40(Predicted)
- 外見 :
- 個体
- 色:
- ホワイトからオフホワイト
- InChI:
- InChI=1S/C13H9FN2O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5H2,(H,15,17,18)
- InChIKey:
- CRAUTELYXAAAPW-UHFFFAOYSA-N
- SMILES:
- C1(=O)C2=C(C(F)=CC=C2)C(=O)N1C1CCC(=O)NC1=O
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 価格
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2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 化学特性,用途語,生産方法
使用
2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione is an intermediate in the synthesis of N-[2-Aminoethyl] Pomalidomide TFA Salt (A6095150. N-[2-Aminoethyl] Pomalidomide TFA is a thalidomide derivative, a potent inhibitor of TNF-α production. It is an anti-inflammatory and anti-tumor agent used in the treatment of multiple myeloma.
合成
A mixture of 4-fluoroisobenzofuran-l,3-dione (498.33 mg, 3.00 mmol), 3- aminopiperidine-2,6-dione hydrogen chloride (493.77 mg, 3.00 mmol) and NaOAc (246.09 mg, 3.00 mmol) in HOAc (10 mL) was stirred at 135 °C overnight, cooled and concentrated in vacuo. The residue was suspended in H2O (100 mL) and stirred at room temperature for 4 hours. The solid was collected via filtration and dried in vacuo to afford 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione as a white solid.
2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 上流と下流の製品情報
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2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione 生産企業
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835616-60-9()キーワード:
- 835616-60-9
- 2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
- E3 ligase Ligand 4
- 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-fl...
- Pomalidomide Related Compound 7
- Thalidomide 4-fluoride
- TC-E3 5032
- E3 ligase Ligand 4(TC-E3 5032)
- 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-fluoro-
- 2-(2,6-dioxo-3-piperidinyl)-4-fluoro-1H-Isoindole-1,3(2H)-dione
- 135582
- 4-Fluoro-thalidomide
- 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1,3-isoindolinedione
- 2-(2,6-Dioxopiperidin-3-yl)-4-fluoro-2,3-dihydro-1H-isoindole-1,3-dione