リボフラビンリン酸エステルナトリウム 化学特性,用途語,生産方法
外観
黄色～赤みの黄色, 結晶性粉末
定義
本品は、リン酸(*)とリボフラビン(*)のエステルのナトリウム塩であり、次の化学式で表される。
参照表示名称：リン酸, リボフラビン
溶解性
水に易溶,pH2で微溶, pH5～7で可溶。エタノール, エーテル, クロロホルムにほとんど不溶。
用途
薬理・生理作用研究用。
用途
酵素研究用。
化粧品の成分用途
皮膚コンディショニング剤
効能
ビタミンB2補充薬
商品名
ビスラーゼ (トーアエイヨー); ビタミンB2 (コーアイセイ); ホスフラン (扶桑薬品工業); ホスフラン (扶桑薬品工業); リボフラビン (日医工)
使用上の注意
吸湿性がある。光によって分解する。
化学的特性
Riboflavin 5'-Monophosphate Sodium Salt is a yellow toorange-yellow, crystalline hygroscopic powder. It is odorless, and has a slightly bitter taste.
It is soluble in water, and practically insoluble in ethanol(95), in chloroform and in diethyl ether.
It is decomposed on exposure to light.
使用
One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).
生物学の機能
Riboflavin 5'-Phosphate Sodium is the phosphate sodium salt form of riboflavin, a water-soluble and essential micronutrient that is the principal growth-promoting factor in naturally occurring vitamin B complexes. Riboflavin phosphate sodium is converted to 2 coenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are necessary for energy production by aiding in the metabolism of fats, carbohydrates and proteins and are required for red blood cell formation and respiration, antibody production and for regulating human growth and reproduction. Riboflavin phosphate sodium is essential for healthy skin, nails and hair growth.
一般的な説明
Riboflavin 5′-monophosphate is also known as flavin mononucleotide (FMN). FMN is a water-soluble micronutrient. It is enzymatically produced from riboflavin (RF). Riboflavin 5′-monophosphate is one of the constituent of enzyme cofactor flavin-adenine dinucleotide.
IC 50
Cryptosporidium hominis TS-DHFR: IC50 = 55 μM; Dihydrofolate reductase: IC50 = 325 μM (human); Thymidylate synthase: IC50 >500 μM (human); Dihydrofolate reductase: IC50 >500 μM (
Toxoplasma gondii)
純化方法
Purify FMN by paper chromatography using tert-butanol/water, cutting out the main spot and eluting it with water. It can also be purified by adsorption onto an apo-flavodoxin column, followed by elution and freeze drying. It crystallises from aqueous acidic solution. [Mayhew & Strating Eur J Biochem 59 539 1976, Beilstein 26 III/IV 2555.]
リボフラビンリン酸エステルナトリウム 上流と下流の製品情報
原材料
準備製品