塩酸ナイトロジェンマスタード-N-オキシド 化学特性,用途語,生産方法
効能
抗悪性腫瘍薬, アルキル化剤
安全性プロファイル
Suspected carcinogen
with experimental tumorigenic data. Poison
by ingestion, subcutaneous, intravenous, and
intraperitoneal routes. Mutation data
reported. An antineoplastic agent. When
heated to decomposition it emits toxic
fumes of Cland NOx.
発がん性
Nitrogen mustard N-oxide is
reportedly carcinogenic in mice and rats. Following subcutaneous
administration in mice, it produced lung tumors,
thymic lymphomas, and Harderian gland adenomas. Mice
given two weekly injections either intravenously, intraperitoneally,
or subcutaneously for 15 weeks showed an increase
in lymphomas, fibrosarcomas, pulmonary adenomas, and
liver hemangiomas. In rats given the material intravenously,
it mainly produced lymphoreticular tumors and
sarcomas. The preceding data were evaluated by the IARC
and considered “sufficient evidence of carcinogenicity in
animals.” Based on this evaluation and its mutagenic potential,
the IARC classified nitrogen mustard N-oxide in Group
2B (possibly carcinogenic to humans).
塩酸ナイトロジェンマスタード-N-オキシド 上流と下流の製品情報
原材料
準備製品