クロフェノタン

クロフェノタン 化学構造式
50-29-3
CAS番号.
50-29-3
化学名:
クロフェノタン
别名:
DDT (ジクロロジフェニルトリクロロエタン);クロロフェノタン;DDT標準品;P,P′-DDT標準品;P,P′-DDT標準液 CRM4201-A;1,1,1トリクロロ2,2ビス(4クロロフェニル)エタン (名DDT);クロフェノタン;DDT(ジクロロジフェニルトリクロロエタン);p,p'-ジクロロジフェニルトリクロロエタン;DDT;1,1,1-トリクロロ-2,2-ビス(4-クロロフェニル)エタン;P,P′‐DDT標準品;P,P′‐DDT標準液;4,4'-DDTクロロフェノタン;4,4′-DDT 溶液;ジクロロジフェニルトリクロロエタン;1-クロロ-4-[2,2,2-トリクロロ-1-(4-クロロフェニル)エチル]ベンゼン;4,4′-[(トリクロロメチル)メチレン]ビス(1-クロロベンゼン);1,1-ビス(4-クロロフェニル)-2,2,2-トリクロロエタン;4,4′-ジクロロジフェニルトリクロロエチレン
英語名:
4,4'-DDT
英語别名:
DDT;P,P'-DDT;R50;DICHLORODIPHENYLTRICHLOROETHANE;1,1,1-TRICHLORO-2,2-BIS(4-CHLOROPHENYL)ETHANE;Clofenotane;CHLOROPHENOTHANE;PEB1;Citox;Detox
CBNumber:
CB5274446
化学式:
C14H9Cl5
分子量:
354.49
MOL File:
50-29-3.mol
MSDS File:
SDS

クロフェノタン 物理性質

融点 :
107-110 °C(lit.)
沸点 :
440.74°C (rough estimate)
比重(密度) :
1.556 g/cm3
蒸気圧:
0.5 at 25 °C (extrapolated from vapor pressures determined at higher temperatures, Tesconi andYalkowsky, 1998)
屈折率 :
1.755
闪点 :
72 °C
貯蔵温度 :
APPROX 4°C
溶解性:
Chloroform: Slightly Soluble; Methanol: Heated
水溶解度 :
水にほとんど溶けない
Merck :
13,2861
BRN :
1882657
Henry's Law Constant:
0.188 at 5 °C, 0.513 at 15 °C, 0.681 at 20 °C, 0.957 at 25 °C, 2.76 at 35 °C:in 3% NaCl solution: 1.15 at 5 °C, 1.88 at 15 °C, 3.36 at 25 °C, 5.43 at 35 °C (gas stripping-GC, Cetin et al., 2006)
暴露限界値:
NIOSH REL: 0.5 mg/m3, IDLH 500 mg/m3; OSHA PEL: TWA 1 mg/m3; ACGIH TLV: TWA 1 mg/m3.
安定性::
安定。可燃性。強力な酸化剤、鉄、アルミニウム、およびそれらの塩と塩基とは相容れない。
IARC:
2A (Vol. Sup 7, 53, 113) 2018
EPAの化学物質情報:
p,p'-DDT (50-29-3)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,N,Xi,F,Xn
Rフレーズ  25-40-48/25-50/53-36/37/38-11-39/23/24/25-23/24/25-52/53-24-67-65-38
Sフレーズ  22-36/37-45-60-61-36-33-26-16-7-62
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS 番号 KJ3325000
国連危険物分類  6.1(b)
容器等級  III
有毒物質データの 50-29-3(Hazardous Substances Data)
毒性 LD50 in male, female rats (mg/kg): 113, 118 orally (Gaines, 1960)
IDLA 500 mg/m3
消防法 危-4-1-II
化審法 (4)-910 第一種特定化学物質
安衛法 57,57-2
環境リスク評価 p,p’-DDT(50-29-3)
絵表示(GHS) GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
注意喚起語 危険
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H351 発がんのおそれの疑い 発がん性 2 警告 P201, P202, P281, P308+P313, P405,P501
H372 長期にわたる、または反復暴露により臓器の障 害 特定標的臓器有害性、単回暴露 1 危険 GHS hazard pictograms P260, P264, P270, P314, P501
H410 長期的影響により水生生物に非常に強い毒性 水生環境有害性、慢性毒性 1 警告 GHS hazard pictograms P273, P391, P501
注意書き
P202 全ての安全注意を読み理解するまで取り扱わないこ と。
P260 粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。
P273 環境への放出を避けること。
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。

クロフェノタン 価格 もっと(10)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01ACSP-029NB-250
p,p'-DDT
50-29-3 250mg ¥31200 2024-03-01 購入
関東化学株式会社(KANTO) 49862-74 p,p′‐DDT標準液
p,p′‐DDT standard solution
50-29-3 10mL ¥15000 2024-03-01 購入
関東化学株式会社(KANTO) 49831-02 p,p′‐DDT標準品
p,p′‐DDT standard
50-29-3 100mg ¥19000 2024-03-01 購入
関東化学株式会社(KANTO) 49831-00 DDT標準品
DDT standard (technical)
50-29-3 250mg ¥25000 2023-06-01 購入
Sigma-Aldrich Japan 40124 certified reference material, 5000?μg/mL in methanol
4,4′-DDT solution certified reference material, 5000?μg/mL in methanol
50-29-3 1mL ¥7700 2024-03-01 購入

クロフェノタン 化学特性,用途語,生産方法

解説

p,p′-ジクロロジフェニルトリクロロエタン,略称DDT.接触性の殺虫剤の一つ.クロロベンゼン2分子とクロラールとを硫酸の存在下に脱水縮合させてつくられるが,工業製品には,p,p′-ジクロロジフェニルトリクロロエタン(65~80%)のほかに,o,p′-ジクロロジフェニルトリクロロエタン(15~20%)などが含まれている.p,p′-ジクロロジフェニルトリクロロエタンは融点109~110 ℃ の結晶で,水に難溶,多くの有機溶媒に可溶.酸に安定であるが,アルカリにより脱塩化水素される.昆虫に対しては神経毒としてはたらき,イエバエなどに効果があるがアブラ虫やダニにはきかない.温血動物に対する毒性は少ないが難分解性であり,現在は使用が禁止されている.LD50 200 mg/kg(ラット,経口).

用途

木材用の防腐剤,防虫剤及びかび防止剤,塗料用(防腐用,防虫用又はかび防止用のものに限る。),殺虫剤(販売禁止農薬) (NITE CHRIP)

効能

殺虫薬

説明

DDT is a polychlorinated persistent chemical that exists as a solid under normal conditions.Even though DDT seemed to be a cheap and effective pesticide, enough was known in its early development to raise concerns. DDT is a persistent chemical that lasts a long time in the environment. DDT is fat-soluble and not readily metabolized by higher organisms. Th is meant that DDT accumulated in the fat tissues of higher organisms.

化学的特性

The technical p,p′-DDT is a waxy solid but in its pure form appears as colourless crystals. It is a mixture of three isomers, namely, p,p′-DDT isomer (about ca. 85%); o,p′-DDT; and o,o′-DDT (in smaller levels). DDT is very soluble in cyclohexanone, dioxane, benzene, xylene, trichloroethylene, dichloromethane, acetone, chloroform, diethyl ether, ethanol, and methanol.

物理的性質

Whites crystals or waxy solid, with a faint, fragrant, aromatic-like odor. Tasteless. Odor threshold concentration is 200 ppb (quoted, Keith and Walters, 1992) and in water, 350 μg/kg (Sigworth, 1964).

使用

4,4'-Dichlorodiphenyltrichloroethane is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyltrichloroethane functions by opening sodium ion channels in the insects’neurons, causing them to f ire spontaneously which in turn leads to death. 4,4'-Dichlorodiphenyltrichloroethane is banned for agricultural use in North America, it is still commonly used in some countries and particularly as a means of malaria control.

定義

ChEBI: A chlorophenylethane that is 1,1,1-trichloro-2,2-diphenylethane substituted by additional chloro substituents at positions 4 of the phenyl substituents. It is a commonly used organochlorine insecticide.

使用

USP記載名はクロロフェノタン。有機合成殺虫剤の先駆をなすもので、1874年にツァイドラーOthmar Zeidler(1859―1911)により合成され、1939年にスイスのP・H・ミュラーによって殺虫力が発見された。第二次世界大戦中ドイツやアメリカで軍用に使用され、戦後は各国でカやハエやシラミなどの衛生害虫、あるいは農作物の害虫防除に広く用いられた。ベンゼンに結合するクロルの位置により4種の異性体があるが、殺虫力の強いのはp,p'(粗製品中約80%)で、白色針状結晶。モノクロルベンゼンとクロラールを硫酸で脱水縮合して合成する。水には溶けない。化学的に、また微生物的に分解しにくい安定な化合物である。DDTは神経繊維に作用する神経毒で、冷血動物に強い毒性を現し、哺乳(ほにゅう)類などの温血動物に対しては概して弱い。食物連鎖によって生物濃縮され、最終的に人体の脂肪組織に蓄積されるため残留毒性が問題となって、1969年(昭和44)より日本では自粛的に生産を中止し、1971年から使用が禁止となった。

一般的な説明

Odorless colorless solid. Sinks in water.

空気と水の反応

Insoluble in water.

反応プロフィール

4,4'-DDT may react with iron, aluminum, aluminum and iron salts, and alkalis. 4,4'-DDT is incompatible with ferric chloride and aluminum chloride. 4,4'-DDT can also react with strong oxidizing materials. .

健康ハザード

Very large doses are followed promptly by vomiting, due to local gastric irritation; delayed emesis or diarrhea may occur. With smaller doses, symptoms usually appear 2-3 hours after ingestion. These include tingling of lips, tongue, and face; malaise, headache, sore throat, fatigue, coarse tremors of neck, head, and eyelids; apprehension, ataxia, and confusion. Convulsions may alternate with periods of coma and partial paralysis. Vital signs are essentially normal, but in severe poisoning the pulse may be irregular and abnormally slow; ventricular fibrillation and sudden death may occur at any time during acute phase. Pulmonary edema usually indicates solvent intoxication.

接触アレルゲン

This insecticide was formerly reported as a sensitizer in farmers or agricultural workers.

薬理学

DDT is a nerve poison that affects the sodium channel of nerve membranes. It is a nonsystemic insecticide with contact and stomach action. The most important reactions of DDT (1) are dehydrochlorination to DDE (2) and reductive dechlorination to DDD (3). These reactions occur abiotically, in vivo and in soils. The products resemble DDT in their recalcitrance toward environmental degradation. The stability of DDT and its principal metabolites DDD and DDE, in combination with their lipid solubility and resistance to biological degradation, resulted in their bioconcentration in fish and other organisms exposed to extremely low levels of these compounds in water. Although metabolism of DDT in mammals may proceed via DDD to give 4,4- dichlorodiphenylacetic acid (5), DDE is also formed and stored in fat. It may be slowly depleted by oxidative reactions, and ringhydroxylated derivativeshave been detected in mammals and wildlife samples. Consumption of DDT residues in wildlife and fish by predators resulted in adverse effects.

毒性学

Although DDT [1,1-(2,2,2-trichloroethylidene)bis(4-chlorobenzene)] has been banned in the United States since 1972, it remains one of the best-known synthetic pesticides. Because DDT is a very nonpolar molecule, it has high lipid solubility. Since DDT is also extremely stable, it accumulates in animal tissues and in the food chain. DDT is still one of the most abundant pesticide residues in food. During the 40 years following DDT s commercial introduction in the 1940s, more than 4 billion pounds were used to control insect-borne diseases. Until 1972, DDT was widely used in the United States, mostly on cotton, peanuts, and soybeans. As a result of its use, DDT residues are now ubiquitous in the environment, and at the present time, some level can be detected in almost all biological and environmental samples. In addition, due to its high lipid solubility, DDT concentrates in milk. When DDT was widely used, levels in human milk and adipose tissue were found to be higher than concentrations permitted in meat and dairy products. However, since its use has been prohibited, storage levels of DDT in human tissue have declined significantly. DDT is, however, still in use in other countries, largely to control insect-borne diseases that pose a substantial threat to public health.

職業ばく露

DDT is a low-cost broad-spectrum insecticide. However, following an extensive review of health and environmental hazards of the use of DDT, United States Environmental Protection Agency decided to ban further use of DDT in December 1972. This decision was based on several properties of DDT that had been well evidenced : DDT and its metabolites are toxicants with long-term persistence in soil and water ; it is widely dis- persed by erosion, runoff, and volatization ; and the low- water solubility and high lipophilicity of DDT result in concentrated accumulation of DDT in the fat of wildlife and humans which may be hazardous.

発がん性

Dichlorodiphenyltrichloroethane (DDT) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

環境運命予測

Biological. In four successive 7-day incubation periods, p,p′-DDT (5 and 10 mg/L) was recalcitrant to degradation in a settled domestic wastewater inoculum (Tabak et al., 1981).
The white rot fungus Phanerochaete chrysosporium degraded p,p′-DDT yielding the following metabolites: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (p,p′-DDD), 2,2,2- trichloro-1,1-bis(4-chlorophenyl)ethanol (dicofol), 2,2-dichloro-1,1-bis(4-chlorophenyl) e
Mineralization of p,p′-DDT by the white rot fungi Pleurotus ostreatus, Phellinus weirri and Polyporus versicolor was also demonstrated (Bumpus and Aust, 1987). Aerobacter aerogenes degraded p,p′-DDT under aerobic conditions to p,p′-DDD, p,p′-DDE, 1-chloro
Under aerobic conditions, the amoeba Acanthamoeba castellanii (Neff strain ATCC 30.010) degraded p,p′-DDT to p,p′-DDE, p,p′-DDD and dibenzophenone (Pollero and dePollero, 1978).
Incubation of p,p′-DDT with hematin and ammonia gave p,p′-DDD, p,p′-DDE, bis(pchlorophenyl) acetonitrile, 1-chloro-2,2-bis(p-chlorophenyl)ethylene, 4,4′-dichlorobenzophenone and the methyl ester of bis(p-chlorophenyl)acetic acid (Quirke et al., 1979).

代謝経路

Upon UV irradiation with methyl oleate, DDT is extensively added to the carbon ? carbon double bond of methyloleate via radical mechanisms. Besides chlorinated stearic acids, several addition products are formed, offering new possibilities to produce bound residues in plants. A mixture of hemin and excess cysteine (the hemin ? cysteine model system) is able to degrade DDT partially and the major degradation products are three water-soluble, non-toxic conjugates of DDT metabolites with cysteine which lose two or three of the five chlorine atoms of DDT. In the presence of a designed 24-residue polypeptide or b-casein, two DDT-binding proteins, an additional fourfold increase in the rate of DDT degradation is observed. Although the concentrations of DDT and cysteine occurring in an organism would be expected to be lower than those in the experiments described, the formation of water-soluble conjugates of DDT with cysteine (and other amino acids) could also play a role in metabolism and excretion of DDT in vivo.

代謝

DDT decomposed very slowly in sunlight, and 93% was recovered unchanged from the surface of an apple after 3 months. DDE decomposed more rapidly than DDT in sunlight. Other reports indicate that DDT was photolyzed under field conditions to give products, including DDE, 4,4- dichlorobenzophenone (6), 4-chlorobenzoyl chloride, 4- chlorobenzoic acid, and 4-chlorophenyl 4-chlorobenzoate. Irradiation of DDT at shorter wavelengths under laboratory conditions gave a variety of products that arose from reactions of photolytically generated radicals.

輸送方法

UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

純化方法

Crystallise DDT from n-propyl alcohol (5mL/g), then dry it in air or an air oven at 50-60o. Alternatively crystallise it from 95% EtOH, and the purity is checked by TLC. [Beilstein 5 III 1833.] TOXIC INSECTICIDE.

不和合性

Contact with strong oxidizers may cause fire and explosion hazard. Incompatible with salts of iron or aluminum, and bases. Do not store in iron containers

廃棄物の処理

Incineration has been success- fully used on a large scale for several years; huge incinera- tor equipment with scrubbers to catch HCl, a combustion product, are in use at several facilities, such as Hooker Chemical, Dow Chemical and other producers of chlori- nated hydrocarbon products. One incinerator operates @ 900 C 1400 C with air and steam added which precludes formation of Cl2. A few companies also constructed incinerator-scrubber combinations of smaller size, e.g., a system built by Garver-Davis, Inc., of Cleveland, Ohio, for the Canadian government, can handle 200 500 lb DDT/ day as a kerosene solution. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by follow- ing package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations govern- ing storage, transportation, treatment, and waste disposal.

クロフェノタン 上流と下流の製品情報

原材料

準備製品


クロフェノタン 生産企業

Global( 98)Suppliers
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クロフェノタン  スペクトルデータ(1HNMR、13CNMR、IR1、IR2、MS、Raman)


50-29-3(クロフェノタン)キーワード:


  • 50-29-3
  • 'LGC' (1112)
  • 1,1'-(2,2,2-trichloroethyliden)bis-(4-chlorobenzol)
  • DDT (common name not adopted by ISO) clofenotane (INN) dicophane 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane dichlorodiphenyltrichloroethane
  • 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane solution, 4,4μ-DDT solution
  • 1,1,1-TRICHLORO-2,2-BIS(P-CHLOROPHENYL)ETHANE
  • 1,1,1-TRICHLORO-2,2-DI(4-CHLOROPHENYL)ETHANE
  • 1,1-BIS(4-CHLOROPHENYL)-2,2,2-TRICHLOROETHANE
  • 2,2-BIS-(4-CHLOROPHENYL)-1,1,1-TRICHLOROETHANE
  • NEOCID(R)
  • PENTACHLORIN(R)
  • P,P'-ZEIDANE
  • α,α-Bis(p-chlorophenyl) β,β,β-trichloroethane
  • 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane solution
  • 4,4'-ddt solution
  • ddt (bsi,iso,esa,jmaf)
  • p,p'-ddt (bsi,iso)
  • zeidane(france)
  • DDT, Tech
  • SORTHOPARADDT
  • 1,1-DI(4-CHLOROPHENYL)-2,2,2-TRICHLOROETHANE
  • 1,1-BIS(PARA-CHLOROPHENYL)-2,2,2-TRICHLOROETHANE
  • 1,1,1-TRICHLORO-2,2-BIS(PARA-CHLOROPHENYL)ETHANE
  • PARAPARADICHLORODIPHENYLTRICHLOROETHANE
  • 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane, 1,1-Bis(4-chlorophenyl)-2,2,2-trichloroethane
  • ANOFEX(R)
  • ANOFLEX
  • CHLOROPHENOTHAN
  • CHOROPHENTHANE
  • DEDELO
  • DICOPHANE(R)
  • DDT (ジクロロジフェニルトリクロロエタン)
  • クロロフェノタン
  • DDT標準品
  • P,P′-DDT標準品
  • P,P′-DDT標準液 CRM4201-A
  • 1,1,1トリクロロ2,2ビス(4クロロフェニル)エタン (名DDT)
  • クロフェノタン
  • DDT(ジクロロジフェニルトリクロロエタン)
  • p,p'-ジクロロジフェニルトリクロロエタン
  • DDT
  • 1,1,1-トリクロロ-2,2-ビス(4-クロロフェニル)エタン
  • P,P′‐DDT標準品
  • P,P′‐DDT標準液
  • 4,4'-DDTクロロフェノタン
  • 4,4′-DDT 溶液
  • ジクロロジフェニルトリクロロエタン
  • 1-クロロ-4-[2,2,2-トリクロロ-1-(4-クロロフェニル)エチル]ベンゼン
  • 4,4′-[(トリクロロメチル)メチレン]ビス(1-クロロベンゼン)
  • 1,1-ビス(4-クロロフェニル)-2,2,2-トリクロロエタン
  • 4,4′-ジクロロジフェニルトリクロロエチレン
  • ネオシド
  • ゲザトックス
  • 1,1′-(2,2,2-トリクロロエチリデン)ビス(4-クロロベンゼン)
  • 2,2-ビス(4-クロロフェニル)-1,1,1-トリクロロエタン
  • ジコファン
  • アノフェックス
  • 1,1-ビス(p-クロロフェニル)-2,2,2-トリクロロエタン
  • フジクロール
  • 1,1-ジ(4-クロロフェニル)-2,2,2-トリクロロエタン
  • 1,1′-(2,2,2-トリクロロエチリデン)ビス[4-クロロベンゼン]
  • ペンタクロリン
  • 4,4′-(2,2,2-トリクロロエチリデン)ビス(クロロベンゼン)
  • 1,1,1-トリクロロ-2,2-ビス(p-クロロフェニル)エタン
  • 分析化学
  • 環境ホルモン
  • 塩素化化合物 (環境ホルモン)
  • 農薬類,殺虫剤および除草剤など
  • 生活関係標準物質
  • 食料品
  • 有機標準物質
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