2,4,6-トリメチルアニリン 化学特性,用途語,生産方法
外観
うすい黄色～暗赤褐色, 澄明の液体
溶解性
水に難溶。有機溶媒に可溶。エタノール及びアセトンに溶け、水にほとんど溶けない。
用途
染料、顔料、その他有機工業薬品中間体。
化学的特性
clear yellow to brown liquid. Insoluble in water, soluble in organic solvents such as ethanol and ether.
使用
2,4,6-Trimethylaniline is useful for the preparation of Grubbs' catalyst. It is used as a precursor to dyes. It undergoes condensation reaction with glyoxal to prepare glyoxal-bis(mesitylimine). It is also involved in the preparation of 1,3-diketimines ligands by condensation with 1,3-diketones. Further, it is used for the production of Acid Blue 129 dye, which is useful in histochemistry studies. In addition to this, it serves as a building block to various bulky ligands.
製造方法
2,4,6-Trimethylaniline is prepared by selective mononitration of mesitylene, avoiding oxidation of the methyl groups.
Mix sulfuric acid and nitric acid into mixed acid, nitrify with mesitylene at atmospheric pressure below 10°C for 4 hours, stand for stratification, and let off the waste acid. The obtained 2,4,6-trimethylnitrobenzene, iron powder, hydrochloric acid and water were prepared in a ratio of 1:3.74:0.9:2.22 (mol ratio) for reduction reaction at 100-105°C for 8h. Crude 2,4,6-Trimethylaniline was then distilled off from the reduced material and purified by distillation.
一般的な説明
2,4,6-Trimethylaniline is a clear liquid. easily turns light brown when exposed to air and light. It is an intermediate for dyes, organic pigments and pesticides.
反応プロフィール
2,4,6-Trimethylaniline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
健康ハザード
2,4,6-Trimethylaniline is moderately toxic orally. It is also considered highly toxic by unspecified routes. It is a skin and eye irritant. Suspect occupational carcinogen. (Non-Specific -- Aromatic Amines) The danger of acute poisoning is represented by methemoglobinemia leading to adverse effects on the red cells. A number of the amines may act as skin sensitizers.
火災危険
When heated to decomposition, 2,4,6-Trimethylaniline emits toxic fumes of nitrogen oxides. Avoid decomposing heat.
安全性プロファイル
Poison by inhalation.
Moderately toxic by ingestion. A skin and
severe eye irritant. Questionable carcinogen
with experimental carcinogenic data.
Mutation data reported. When heated to
decomposition it emits toxic fumes of NOx.
職業ばく露
Used on small scale in organic
synthesis.
輸送方法
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required.
2,4,6-トリメチルアニリン 上流と下流の製品情報
原材料
準備製品
1-アミノ-4-[(2,4,6-トリメチルフェニル)アミノ]-9,10-ジヒドロ-9,10-ジオキソアントラセン-2-スルホン酸ナトリウム
Ｎ，Ｎ－ジエチル－３－（２，４，６－トリメチルフェニルスルホニル）－１Ｈ－１，２，４－トリアゾール－１－カルボキサミド
1,4-ビス(メシチルアミノ)アントラキノン
Tracid Light Yellow G
3,3'-[(9,10-ジヒドロ-9,10-ジオキソアントラセン-1,4-ジイル)ジイミノ]ビス[2,4,6-トリメチルベンゼンスルホン酸ナトリウム]
(E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile
1,4-ジシアノナフタレン
3-ブロモ-2,4,6-トリメチルアニリン
メシチル ヨージド
1,3-ビス(2,4,6-トリメチルフェニル)イミダゾリニウムクロリド
Acid Violet 48
1-アミノ-4-[(2,4,6-トリメチルフェニル)アミノ]-9,10-ジヒドロ-9,10-ジオキソアントラセン-2-スルホン酸ナトリウム
1,4-ビス(メシチルアミノ)アントラキノン
1-アミノ-4-[(2,4,6-トリメチル-3-スルホフェニル)アミノ]-9,10-ジヒドロ-9,10-ジオキソアントラセン-2-スルホン酸2-ナトリウム
Acid Violet 126
3,3'-[(9,10-ジヒドロ-9,10-ジオキソアントラセン-1,4-ジイル)ジイミノ]ビス[2,4,6-トリメチルベンゼンスルホン酸ナトリウム]
grubbs触媒世代