[S,(+)]-グリセリン1-バレラート 化学特性,用途語,生産方法
外観
白色〜ほとんど白色, 結晶性粉末〜粉末
溶解性
水に極めて易溶、ぎ酸, エタノール, 氷酢酸に易溶。アセトンにほとんど溶けない。
用途
GABAトランスアミナーゼ阻 害作用を示します。
用途
薬理、生理作用研究用。
用途
抗てんかん剤、躁病および躁うつ病の躁状態の治療薬
効能
抗けいれん薬, 躁状態治療薬, 抗片頭痛薬, 抗てんかん薬
商品名
セレニカ (興和); セレニカ (興和); セレニカ (興和); セレニカ (興和); デパケン (協和発酵キリン); デパケン (協和発酵キリン); デパケン (協和発酵キリン); デパケン (協和発酵キリン)
化学的特性
White Solid. Colorless crystalline powder, hygroscopic, very soluble in water (ca. 0.66 g/mL of solution), soluble in ethanol (ca. 0.2 g/mL of solution), practically insoluble in chloroform and diethyl ether.
使用
Antiepileptic; increases levels of GABA in the brain
定義
ChEBI: The sodium salt of valproic acid.
一般的な説明
A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC
50 = 400 μM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 μM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.
生物活性
Histone deacetylase inhibitor (IC 50 = 400 μ M) that exhibits anticancer, anti-inflammatory and neuroprotective effects. Displays anticonvulsive activity via an increase in GABA levels and decreases A β production in animal models of Alzheimer's disease. Also attenuates NMDA-mediated excitation, blocks voltage-gated Na + channels and modulates firing of neurons. Enables induction of pluripotent stem cells from somatic cells by Oct4 and Sox2.
[S,(+)]-グリセリン1-バレラート 上流と下流の製品情報
原材料
準備製品