プラモキシン塩酸塩
プラモキシン塩酸塩 物理性質
- 融点 :
- 181-183°
- 貯蔵温度 :
- Inert atmosphere,Room Temperature
- 溶解性:
- クロロホルム（微量）、メタノール（微量）
- 色:
- ホワイトからオフホワイト
- 安定性：:
- Hygroscopic
- InChI:
- InChI=1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H
- InChIKey:
- SYCBXBCPLUFJID-UHFFFAOYSA-N
- SMILES:
- C1(OCCCN2CCOCC2)=CC=C(OCCCC)C=C1.Cl
- LogP:
- 3.477 (est)
- CAS データベース:
- 637-58-1(CAS DataBase Reference)
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
| 絵表示（GHS） |
|
| 注意喚起語 |
警告 |
| 危険有害性情報 |
| コード |
危険有害性情報 |
危険有害性クラス |
区分 |
注意喚起語 |
シンボル |
P コード |
| H302 |
飲み込むと有害 |
急性毒性、経口 |
4 |
警告 |
|
P264, P270, P301+P312, P330, P501 |
| H315 |
皮膚刺激 |
皮膚腐食性/刺激性 |
2 |
警告 |
|
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
強い眼刺激 |
眼に対する重篤な損傷性/眼刺激 性 |
2A |
警告 |
|
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
呼吸器への刺激のおそれ |
特定標的臓器毒性、単回暴露； 気道刺激性 |
3 |
警告 |
|
|
|
| 注意書き |
| P261 |
粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。 |
| P264 |
取扱い後は皮膚をよく洗うこと。 |
| P264 |
取扱い後は手や顔をよく洗うこと。 |
| P270 |
この製品を使用する時に、飲食または喫煙をしないこ と。 |
| P301+P312 |
飲み込んだ場合：気分が悪い時は医師に連絡する こと。 |
| P302+P352 |
皮膚に付着した場合：多量の水と石鹸で洗うこと。 |
| P305+P351+P338 |
眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。 |
|
プラモキシン塩酸塩 価格
もっと(9)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-0664 |
Pramoxine, HCl |
637-58-1 |
5g |
￥10000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-0664 |
Pramoxine, HCl |
637-58-1 |
1g |
￥10000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
P9422 |
analytical standard, ≥98%
Pramoxine hydrochloride analytical standard, ≥98% |
637-58-1 |
10g |
￥8300 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
1554002 |
United States Pharmacopeia (USP) Reference Standard
Pramoxine hydrochloride United States Pharmacopeia (USP) Reference Standard |
637-58-1 |
400mg |
￥55400 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBOR-0664 |
Pramoxine, HCl |
637-58-1 |
25g |
￥25000 |
2024-03-01 |
購入 |
プラモキシン塩酸塩 化学特性,用途語,生産方法
効能
外用鎮痛薬, 表面麻酔薬
説明
Pramoxine, also known as pramocaine, is different from other local anesthetic compounds in chemical structure. Active groups which are carboxylic acid derivatives like ester and amide are not present in this molecule. The drug molecule consists of ether functional groups that are much less active on a chemical level. The presence of the free radical morpholine in this compound is the cause of the reduction of the factor of toxicity and pharmacological activity. In pramoxine, toxicity is reduced but the local anesthetic affect is maintained.
使用
Pramoxine Hydrochloride is used as a local anaesthetic and often in anti-itch formulations that provides temporary relief from itching caused by insect bites, minor skin irritations, poison ivy, sunburn and more.
適応症
Pramoxine hydrochloride (Itch-X, PrameGel, Prax, Tronothane, AmLactin AP) is a
local anesthetic that is structurally similar to dyclonine and unrelated to the esteror
amide-type compounds.Apply to affected area t.i.d. to q.i.d., as directed by a physician. Useful for
patients sensitive to ester and/or amide anesthetics. Onset of anesthesia is within
minutes. Duration of anesthesia is 2 to 4 hours.
臨床応用
Pramoxine is an amino-ether which, like dyclonine, is used as a topical agent in the form of its hydrochloride. Pramoxine hydrochloride may be used for anaesthesia of minor skin wounds and the relief of haemomhoids and other anorectal disorders.The drug is an ingredient of many proprietary topical products, and the U.S.P. has official cream and gel formulations.
Mode of action
Pramoxine hydrochloride is the hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property. Pramocaine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.
プラモキシン塩酸塩 上流と下流の製品情報
原材料
準備製品
プラモキシン塩酸塩 生産企業
Global( 296)Suppliers
プラモキシン塩酸塩 スペクトルデータ(1HNMR)
637-58-1(プラモキシン塩酸塩)キーワード:
- 637-58-1
- TRONOTHANE HYDROCHLORIDE USP
- 4-n-Butoxyphenylg-morpholinopropyletherhydrochlorideusp
- Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride (1:1)
- Pramoxine hydrochloride
4-n-Butoxyphenyl gamma-morpholinopropyl ether hydrochloride
- Pramoxine Hydrochloride (400 mg)
- PRAMOXINEHYDROCHLORIDE,USP
- MORPHOLINE,4-(3-(PARA-BUTOXYPHENOXY)PROPYL)-,HYDROCHLORIDE
- 4-[3-(P-BUTOXYPHENOXY)PROPYL]MORPHOLINE HYDROCHLORIDE USP
- Proxazocaine hydrochloride
- Pramoxine Hydrochloride (500 mg)
- PraMoxine HCL API
- 4-(3-(4-butoxyphenoxy)propyl)Morpholine hydrochloride
- 4-(3-(p-butoxyphenoxy)propyl)-morpholinhydrochloride
- gamma-morpholinopropyl4-n-butoxyphenyletherhydrochloride
- p-butoxyphenylgamma-morpholinopropyletherhydrochloride
- proctofoam
- PRAMOXINE HYDROCHLORIDE
- PRAXOMINE HYDROCHLORIDE
- TRONOTHANE HYDROCHLORIDE
- 4-[3-(P-BUTOXYPHENOXY)PROPYL]MORPHOLINE HYDROCHLORIDE
- 4-n-butoxyphenyl gamma-morpholinopropyl ether hydrochloride
- 4-N-BUTOXYPHENYL G-MORPHOLINOPROPYL ETHER HYDROCHLORIDE
- pramocaine hydrochloride
- Pramoxine Hydrochloride 637-58-1
- 99.9% raw powder Pramocaine hydrochloride for antipruritic use
- Pramoxine Hcl USP38
- Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride
- Pramoxine D8 hydrochloride
- Pramoxine Hydrochloride (1554002)
- PRAMOXINE HCL
- プラモキシン塩酸塩
- プロキサゾカイン塩酸塩
- 塩酸プラモカイン
- 4-[3-(p-ブトキシフェノキシ)プロピル]モルホリン·塩酸塩
- トロノタン塩酸塩
- プラモカイン塩酸塩
- プラムオキシン塩酸塩
- 4-[3-(p-ブトキシフェノキシ)プロピル]モルホリン・塩酸塩