rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート] 化学特性,用途語,生産方法
定義
本品は、オレイン酸(*)とグリセリン(*)のモノエステルであり、次の化学式で表される。
参照表示名称:オレイン酸, グリセリン
化粧品の成分用途
エモリエント剤、乳化剤、香料
説明
Glyceryl monooleate (GMO), generally referred to as monoolein (MO), is FDA approved amphiphilic lipid that is widely used during the synthesis of cubosomes. Glyceryl monooleate is a waxy material, but its physical form is dependent on the content of di- and triglyceride. GMO is a polar unsaturated monoglyceride that can self-assemble in water into bicontinuous cubic structures. The amphiphilic chemical structure of GMO with hydrophilic polar head (hydroxyl groups) and hydrophobic chains in the tail facilitates H-bond formation with water. GMOs are classified as GRAS (generally recognized as safe) due to their biodegradability, biocompatibility, and minimal toxicity. The biodegradability was attributed to the lipolysis of GMOs in different tissues via esterase activity. The GMO-based systems, especially bicontinuous cubic and hexagonal LC phases, were highly reported as promising drug delivery. Thanks to their unique features, which include their minimal toxicity, prolonged release rate, and thermodynamic stability upon exposure to excess water.
使用
93% 1-Oleoyl, 7% 2-oleoyl
定義
An antifog agent and dispersant.
調製方法
Glyceryl monooleate is prepared by the esterification of glycerol
with fatty acids, chiefly oleic acid. As the fatty acids are not pure
substances, but rather a mixture of fatty acids, the product obtained
from the esterification will contain a mixture of esters, including
stearic and palmitic. Di- and triesters may also be present. The
composition and, therefore, the physical properties of glyceryl
monooleate may thus vary considerably from manufacturer to
manufacturer; e.g. the melting point may vary from 10–35°C.
応用例(製薬)
Glyceryl monooleate is a polar lipid that swells in water to give
several phases with different rheological properties. It is available
in both nonemulsifying (n/e) and self-emulsifying (s/e) grades, the
self-emulsifying grade containing about 5% of an anionic surfactant.
The nonemulsifying grade is used in topical formulations as an
emollient and as an emulsifying agent for water-in-oil emulsions. It
is also a stabilizer for oil-in-water emulsions. The self-emulsifying
grade is used as a primary emulsifier for oil-in-water systems.
Glyceryl monooleate gels in excess water, forming a highly
ordered cubic phase that can be used to sustain the release of
various water-soluble drugs.It is also the basis of mucoadhesive
drug delivery systems.
Glyceryl monooleate is reported to enhance transdermal and
buccal penetration.
安全性プロファイル
When heated to
decomposition it emits acrid smoke and irritating fumes.
安全性
Glyceryl monooleate is used in oral and topical pharmaceutical
formulations and is generally regarded as a relatively nonirritant
and nontoxic excipient.
貯蔵
Glyceryl monooleate should be stored in an airtight container,
protected from light in a cool, dry place.
不和合性
Glyceryl monooleate is incompatible with strong oxidizing agents.
The self-emulsifying grade is incompatible with cationic surfactants.
規制状況(Regulatory Status)
GRAS listed. Included in the FDA Inactive Ingredients Database
(oral capsules, oral powder, oral tablets; creams, controlled-release
transdermal films). Included in nonparenteral medicines licensed in
the UK. Included in the Canadian List of Acceptable Non-medicinal
Ingredients.
rac-(2R*)-プロパン-1,2,3-トリオール1-[(9Z)-9-オクタデセノアート] 上流と下流の製品情報
原材料
準備製品