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フマル酸

CAS番号. 110-17-8
化学名: フマル酸
别名: フマル酸;(E)-ブタ-2-エン二酸;trans-2-ブテン二酸
英語化学名: Fumaric acid
英語别名: FA;TMEDA;U-1149;fumaric;NSC-2752;FEMA 2488;Fumarsure;boleticacid;FUMARSAEURE;Boletic acid
CBNumber: CB5852804
分子式: C4H4O4
分子量: 116.07
MOL File: 110-17-8.mol
フマル酸 物理性質
融点 : 298-300 °C (subl.)(lit.)
比重(密度) : 1.62
蒸気圧: 1.7 mm Hg ( 165 °C)
FEMA : 2488 | FUMARIC ACID
闪点 : 230 °C
貯蔵温度 : Store below +30°C.
溶解性: 95% ethanol: soluble0.46g/10 mL, clear, colorless
外見 : Fine Crystalline Powder
酸解離定数(Pka): 3.02, 4.38(at 25℃)
色: White
PH: 2.1 (4.9g/l, H2O, 20℃)
爆発限界(explosive limit): 40%
水溶解度 : 0.63 g/100 mL (25 ºC)
Merck : 14,4287
BRN : 605763
安定性:: Stable at room temperature. Decomposes at around 230 C. Incompatible with strong oxidizing agents, bases, reducing agents. Combustible.
CAS データベース: 110-17-8(CAS DataBase Reference)
NISTの化学物質情報: Fumaric acid(110-17-8)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xi
Rフレーズ  36
Sフレーズ  26
RIDADR  UN 9126
WGK Germany  1
RTECS 番号 LS9625000
TSCA  Yes
有毒物質データの 110-17-8(Hazardous Substances Data)
絵表示(GHS)
注意喚起語 Warning
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H319 強い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 P264, P280, P305+P351+P338,P337+P313P
注意書き
P280 保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。
P305+P351+P338 眼に入った場合:水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。
P337+P313 眼の刺激が続く場合:医師の診断/手当てを受けること。

フマル酸 化学特性,用途語,生産方法

説明
Fumaric acid is an important kind of organic chemical raw materials as well as the intermediate of fine chemical products. Meanwhile, it is also an important kind of derivatives of maleic anhydride, being widely used in food, coatings, resins and plasticizers. In the food industry, fumaric acid, used as souring agent, can be applied to soft drinks, western-style wine, cold drinks, fruit juice concentrate, canned fruit, pickles and ice cream. As an acidic substance used as solid beverage gas production agent, it has excellent bubble durability with delicate product organization.
Fumaric acid has been used as a food acidulant since 1946. As a food additive, it is used as an acidity regulator and can be denoted by the E number E297. Chemically it is an unsaturated dicarbonic acid and is part of the citric acid cycle.
Fumaric acid is a common food additive included in many processed foods to keep them stable and to add tartness. The substance has a more sour flavor than citric acid, another common food additive. Fumaric acid occurs naturally in fumitory, bolete mushrooms, lichen and Iceland moss. As an additive, fumaric acid is produced synthetically, mainly from malic acid from apples. Fumaric acid as an additive is regulated under the Codex Alimentarius General Standard for Food Additives (GSFA), a collection of internationally recognized standards.The U.S. Food and Drug Administration considers it safe.
化学的特性
Fumaric acid is naturally presented in Corydalis, mushrooms and fresh beef. Product precipitated from the water is monoclinic needle-like, prismatic or leaf-like white crystalline or crystalline powder. It is odorless with a special and strong sour, which is about 1.5 times that of the citric acid. It has a melting point 287 ° C, the boiling point of 290 ° C with subjecting to sublimation at temperature above 200 ° C. When being heated to 230 ° C, it will lose water and become maleic anhydride. Its co-boiling with water can produce DL-malic acid. It is soluble in ethanol, slightly soluble in water and ether, but insoluble in chloroform. The pH value of the 3% aqueous solution is 2.0 to 2.5 with a strong buffering performance, in order to maintain the pH of the aqueous solution at around 3.0. This product is non-toxic; rat-oral LD50: 8000mg/kg.
使用
1. Fumaric acid is used for the production of unsaturated polyester resin. This kind of resin is characterized by excellent resistance to chemical corrosion as well as heat resistance; the copolymer of fumaric acid and vinyl acetate is a kind of excellent adhesive. Its copolymer with styrene copolymer is the raw material for the manufacture of glass fiber. The plasticizer of the fumaric acid is non-toxic and can be applied to the vinyl acetate latex contact with food. This product is the intermediate of pharmaceutical and optical bleaching agents and other fine chemicals. Neutralization of fumaric acid with sodium carbonate can generate sodium fumarate ([17013-01-3]), and then replaced with ferrous sulfate to get iron fumarate, being the drug Fersamal used for the treatment of small red blood cell anemic. The product, as a food additive-sourness agent, used in soft drinks, fruit sugar, jelly, ice cream with most of them used in combination with sourness agent, citric acid. The monosidum salt made from the reaction between fumaric acid and sodium hydroxide can also used as sour seasoning, also used as the intermediate of synthetic resin and mordant.
2. Fumaric acid is included in many dairy-based products. These include dairy drinks such as chocolate milk, cocoa, eggnog, condensed milk and whey protein beverages. It also may be added to clotted cream, milk and cream powders and milk and cream analogues (substitutes). Fumaric acid is added to cheese products, including processed cheese and cheese substitutes. Dairy-based desserts, such as pudding, flavored yogurt, sherbet and sorbet may include fumaric acid as well. Dairy fat spreads and blended spreads can include fumaric acid, and so can preserved eggs and egg-based desserts such as custard.
3. Some processed and packaged foods have fumaric acid added to them to help stabilize them and enhance their flavor. For example, many processed meats, such as bacon and canned meats, have added fumaric acid. Frozen seafood, smoked meats and the edible casings around sausages might also have fumaric acid added to them. Fermented, canned, dried and processed fruits and vegetables can contain the food additive as well. Rice cakes and other precooked rice foods, dried or preserved eggs, mustard, vinegar, cider, wine and other alcoholic beverages are additional examples of foods that might contain fumaric acid.
使用
Occurs in many plants. Essential to vegetable and tissue respiration. Used as an antioxidant.
定義
ChEBI: A butenedioic acid in which the C2C double bond has E geometry. It is an intermediate metabolite in the citric acid cycle.
一般的な説明
A colorless crystalline solid. The primary hazard is the threat to the environment. Immediate steps should be taken to limit spread to the environment. Combustible, though may be difficult to ignite. Used to make paints and plastics, in food processing and preservation, and for other uses.
空気と水の反応
Slightly soluble in water.
反応プロフィール
Fumaric acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in Fumaric acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. Partial carbonization and formation of maleic anhydride occur at 446° F (open vessel).
健康ハザード
Inhalation of dust may cause respiratory irritation. Compound is non-toxic when ingested. Prolonged contact with eyes or skin may cause irritation.
フマル酸 上流と下流の製品情報
原材料
アンモニウムブロミド マレイン酸 無水マレイン酸 鉱油 D-(+)-サッカロース 4-O-(α-D-グルコピラノシル)-D-グルコピラノース ベンゼン [アミノ酸配列分析用] 塩素酸ナトリウム ブチレン チオ尿素 [一般有機合成用]
準備製品
フマロニトリル フマリルクロリド (E)-2-ブテン二酸鉄(II) (E)-2-ブテン二酸ビス(フェニルメチル) L-アスパラギン酸 D-(-)-酒石酸 rac-(R*)-2-ヒドロキシブタン二酸 L-アラニン フマル酸ジナトリウム 4-(アミノメチル)-1-ベンジルピロリジン-2-オン·0.5フマル酸 フマル酸ジエチル フマル酸ジメチル 4-[4-(TERT-ブトキシカルボニル)ピペラジノ]安息香酸 2α-[2-[3-[[2-(1,3-ベンゾジオキソール-5-イルオキシ)エチル]メチルアミノ]プロポキシ]-5-メトキシフェニル]-4-メチル-2H-1,4-ベンゾチアジン-3(4H)-オン 2-ブロモブタン二酸 6-メチルクマリン こはく酸
フマル酸 生産企業      Global( 416)Suppliers     
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110-17-8(フマル酸) キーワード:
(E)-2,3-ジシアノ-2-ブテン二酸ジエチル 3-スルホレン (E)-2-ブテン二酸鉄(II) ヒアルロン酸 (トサカ製) 無水マレイン酸 マレイン酸 フマル酸ジエチル フマル酸ジメチル くえん酸 フマル酸 ビソプロロール·0.5フマル酸 2-[2-[4-[ジベンゾ[b,f][1,4]チアゼピン-11-イル]ピペラジン-1-イル]エトキシ]エタノール/(E)-2-ブテン二酸,(2:1) マレイン酸モノメチル 葉酸水和物 ステアリン酸 4,9-ジヒドロ-4-(1-メチル-4-ピペリジニリデン)-10H-ベンゾ[4,5]シクロヘプタ[1,2-b]チオフェン-10-オン·(E)-2-ブテン二酸 1-ブテン フマロニトリル
110-17-8 acidefumarique Allomaleic acid allomaleicacid Boletic acid boleticacid Butenedioic acid, (E)- femanumber:2488 fumaric Kyselina fumarova kyselinafumarova kyselinafumarova(czech) NSC-2752 trans-1,2-ethenedicarboxylicacid trans-2-ethenedicarboxylicacid trans-Ethylene-1,2-dicarboxylicacid Tumaric acid U-1149 USAF ek-p-583 usafek-p-583 TRANS-2-BUTEN-1,4-DIOIC ACID TRANS-2-BUTENEDIOIC ACID TRANS-BUTENEDICARBOXYLIC ACID TRANS-BUTENEDIOIC ACID TRANS-1,2-ETHYLENEDICARBOXYLIC ACID TRANS-1,2-ETHYLENTRICARBOXYLIC ACID RARECHEM AL BO 0142 ACIDUM FUMARICUM 2-BUTENEDIOIC ACID LICHENIC ACID (e)-1,2-ethenedicarboxylic acid フマル酸 (E)-ブタ-2-エン二酸 trans-2-ブテン二酸
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