メバロン酸 化学特性,用途語,生産方法
解説
メバロン酸，(3R)-メバロノラクトンは融点28 ℃，沸点100～108 ℃(0.7 Pa)．[α]20D－23°(エタノール)．(R,S)-メバロノラクトン：融点27～28 ℃，沸点110 ℃(13.3 Pa)．いずれも，水，極性有機溶媒に対して易溶．
用途
製造用剤
製法
メバロン酸，化学的にはリナロオールより生合成される．また，4-アセトキシ-2-ブタノンとブロモ酢酸エチルとを縮合させ，生成物を加水分解すると(R,S)-メバロノラクトンが得られる．
使用
Precursor in the biosynthesis of cholesterol. Occurs in equilibrium with the d-lactone
定義
Anorganic acid, it is an intermediate in the biosyn-thesis of squalene, cholesterol, and coenzyme q inplants and animals.
生合成
Mevalonic acid is the primary precursor of an the terpenoids and steroids biosynthesised by plants. It is derived from acetyl CoA through the intermediate formation of acetoacetyl CoA and 3-hydroxy-3-methylglutaryl CoA (HMG CoA), these reactions being catalysed by acetyl CoA acetyltransferase and HMG CoA synthase, respectively. Reduction of HMG CoA, catalysed by HMG CoA reductase, gives mevalonic acid.
Before the pathway can continue, mevalonic acid must be catalytically phosphorylated by ATP and mevalonic acid kinase. Mevalonic acid kinase activity has been detected in many plants and has been found to be inhibited by such products of the acetate-mevalonate pathway as geranyl, farnesyl, geranylgeranyl and phytyl pyrophosphates. Thus, phosphorylation of mevalonic acid is a primary point at which control of terpenoid and steroid biosynthesis operates. Phosphorylation leads first to the mono- and then to the pyrophosphate. The second phosphorylation is catalysed by phosphomevalonate kinase.
メバロン酸 上流と下流の製品情報
原材料
準備製品