ヒドロキシエチルスターチ

ヒドロキシエチルスターチ 化学構造式
9005-27-0
CAS番号.
9005-27-0
化学名:
ヒドロキシエチルスターチ
别名:
ヒドロキシエチルスターチ;ヒドロキシエチルデンプン
英語名:
Hydroxyethyl starch
英語别名:
hes;RRp;2-hydroxyethyl ether starch;Hydroxyethyl starch (high Mw) CRS;ES130;ES/130;D03335;essex1360;hespander;penford290
CBNumber:
CB6376714
化学式:
(C6H10O5)m(C2H5O)n
分子量:
0
MOL File:
Mol file

ヒドロキシエチルスターチ 物理性質

融点 :
>224oC (dec.)
貯蔵温度 :
-20°C
溶解性:
水およびジメチルスルホキシドに溶け、無水エタノールにはほとんど溶けない。ヒドロキシエチル澱粉は、水分含有量が約 12% から 15% に達するまで吸湿性があります。
色:
ホワイトからオフホワイト
CAS データベース:
9005-27-0(CAS DataBase Reference)
EPAの化学物質情報:
Starch, 2-hydroxyethyl ether (9005-27-0)

安全性情報

WGK Germany  2
RTECS 番号 WI0410000

ヒドロキシエチルスターチ 価格 もっと(6)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan Y0001277 ヒドロキシエチルスターチ European Pharmacopoeia (EP) Reference Standard
Hydroxyethyl starch (medium MW) European Pharmacopoeia (EP) Reference Standard
9005-27-0 y0001277 ¥24800 2024-03-01 購入
Sigma-Aldrich Japan Y0001322 ヒドロキシエチルスターチ European Pharmacopoeia (EP) Reference Standard
Hydroxyethyl starch (high MW) European Pharmacopoeia (EP) Reference Standard
9005-27-0 y0001322 ¥24800 2024-03-01 購入
Sigma-Aldrich Japan Y0001322 European Pharmacopoeia (EP) Reference Standard
Hydroxyethyl starch European Pharmacopoeia (EP) Reference Standard
9005-27-0 ¥35200 2021-03-23 購入
Sigma-Aldrich Japan Y0001277 European Pharmacopoeia (EP) Reference Standard
Hydroxyethyl starch European Pharmacopoeia (EP) Reference Standard
9005-27-0 ¥35200 2021-03-23 購入
Sigma-Aldrich Japan H6382 ヒドロキシエチルスターチ
Hydroxyethyl starch
9005-27-0 1kg ¥41400 2018-12-25 購入

ヒドロキシエチルスターチ 化学特性,用途語,生産方法

説明

Hydroxyethyl starch (HES) is a synthetic colloid that consists of hydroxyethylated polymers of glucose, derived from amylopectin. It is one of the most frequently used plasma substitutes. HES products are approved for the treatment of hypovolemia (low blood volume).

化学的特性

White to light yellow powdery solid, non-toxic and odorless. It is easily soluble in water and insoluble in organic solvents. It has properties such as emulsification, dispersion, suspension, and adhesion, and can be used as an aid in filtration and retention of pulp materials. It can also reduce the chemical oxygen demand and biochemical oxygen demand of wastewater.

使用

Hydroxyethyl starch, commonly known as Hespen, is a synthetic colloid volume expander, mainly used for first aid in patients with hemorrhagic shock, traumatic shock, and burn shock. Its characteristic is that it is not restricted by blood type. An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other problems.

製造方法

Hydroxyethyl starch is produced by the hydroxyethylation reaction of hydrolyzed starch with ethylene oxide and sodium hydroxide.

一般的な説明

Hydroxyethyl starches (HES) are nonionic starch derivatives and were one of the most frequently used intravascular volume expanders.

臨床応用

Hydroxyethyl starch is often used as a plasma substitute for therapy of hypovolemia after trauma, burns, infections or during surgery.It is also widely used for hemodilution treatment of cerebral ischemia and of retinal, otogenic or peripheral perfusion disturbances.In treatment of cerebral ischemia, a hypervolemic therapy protocol has been shown to be more effective than an isovolemic infusion. Another indication is the hyperdynamic treatment of vasospasm in subarachnoid hemorrhage.Some of these indications require relatively high dosages to ensure efficacy of therapy.However, during continuous treatment with large volumes of HES, disturbances of coagulation and hemor- rhagic complications are not uncommon. Trumble et al. reported bleeding complications during hetastarch therapy of vasospasm in subarachnoid hemorrhage patients and recommended the use of plasma protein fraction instead.Van den Brink observed coagulopathy under therapy with highly sub- stituted medium molecular weight HES.These disturbances of the coagulation sys-tem were found to be due to an acquired von Willebrand syndrome.

代謝

Ten volunteers were given 500 ml 6% HES solution by intravenous infusion, and serial blood and urine samples were collected for nonglucose total carbohydrate determination. On average, 46 and 64 percent of the dose was excreted in the urine within two and eight days. The plasma concentration declined rapidly during the first week after infusion. The average terminal half-life was 17 days during the first 42 days, which accounted for the elimination of about 90 percent of the dose. The remainder was eliminated with a terminal half-life of 48 days determined between days 42 and 83 of the study. The infusion of HES resulted in plasma volume expansion over a 48-hour when nonglucose carbohydrates were above 3.5 mg/ml. HES is metabolized by alpha-amylase in the body. During the first 48 hours after infusion of HES, plasma alpha-amylase activity was significantly increased over control. Concomitantly, alpha-amylase activity in urine was also elevated but not significantly so[1].

ヒドロキシエチルスターチ 上流と下流の製品情報

原材料

準備製品


ヒドロキシエチルスターチ 生産企業

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9005-27-0(ヒドロキシエチルスターチ)キーワード:


  • 9005-27-0
  • Hydroxyethyl Starch 200/0.5(130/0.4)
  • ES130
  • ES/130
  • Anti-RRBP1 (C-terminal) antibody produced in rabbit
  • Hydroxyethyl starch (high MW)
  • Hetastarch,Hydroxyethyl starch, Hydroxyethylated amylopectin
  • Hydroxyethylated starch (jan)
  • Hydroxyethylated starch
  • Hetastarch (usan)
  • Hespan (tn)
  • D03335
  • Hydroxyethyl starch, Hydroxyethylated amylopectin
  • Starch 2-hydroxyethyl ether
  • HES 200/0.5
  • HES 130/0.4
  • Hydroxyethyl Starch 200/0.5
  • HYDROXYETHYL STARCH
  • Hydroxyethyl starch (medium MW)
  • Hydroxyethylated amylopectin
  • tapiocastarchhydroxyethylether
  • starchhydroxyethylether
  • plasmasteril
  • penfordp208
  • penford290
  • 2-hydroxyethylstarchether
  • essex1360
  • 2-HYDROXYETHYL STARCH
  • essexgum1360
  • ethylexgum2020
  • hespander
  • ヒドロキシエチルスターチ
  • ヒドロキシエチルデンプン
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