ピリチオン亜鉛 化学特性,用途語,生産方法
外観
白色～うすい褐色, 結晶性粉末～粉末又は塊
定義
本品は、次の化学式で表される芳香族亜鉛化合物である。
溶解性
塩酸に溶け、水にほとんど溶けない。
用途
金属イオンの存在で錯化合物をつくり着色します.
工業用殺菌剤
用途
LC/MS・LC分析の標準品として使用
用途
ふけ防止シャンプー.農業用殺菌剤 防菌?防カビ?防藻剤
化粧品の成分用途
ヘアコンディショニング剤、防腐剤、抗フケ剤、殺菌剤
効能
抗菌薬, 抗真菌薬, 脂漏性湿疹薬
主な用途／役割
ふけ防除剤、殺菌剤として用いられます。
使用上の注意
光で分解されます。遮光保存して下さい。
説明
Zinc pyrithione is a coordination complex of zinc and pyrithione that has antimicrobial and anticancer activities. It is active against the bacteria
E. coli,
S. aureus,
K. pneumoniae,
A. baumannii,
P. aeruginosa,
E. faecium,
E. faecalis, and
E. cloacae (MICs = 1-4 μg/ml) and the fungus
P. ovale when used at concentrations ranging from 0.01 to 10 μg/ml. Zinc pyrithione reduces tumor growth in an SCC-4 mouse xenograft model when administered at a dose of 1 mg/kg per week for six weeks. Formulations containing zinc pyrithione have been used in the treatment of dandruff.
化学的特性
Beige granules
使用
Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks.
Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.
適応症
Zinc pyrithione is the active ingredient in several shampoos used to control
dandruff and seborrheic dermatitis and is also effective in the therapy of tinea
versicolor. It remains unclear whether the beneficial effects are caused by an
antiproliferative or antimicrobial effect or both. It is substantive to the hair,
allowing continued therapeutic effect after washing.
一般的な説明
Fine beige granules.
空気と水の反応
Insoluble in water.
反応プロフィール
Organometallics, such as Zinc pyrithione, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases.
火災危険
Flash point data for Zinc pyrithione are not available, but Zinc pyrithione is probably combustible.
接触アレルゲン
Zinc pyrithione is widely used in antidandruff
shampoos and is a classic allergen. Concomitant reactions
are expected to both zinc and sodium pyrithione.
安全性プロファイル
Poison by ingestion,
skin contact, intraperitoneal, and
intravenous routes. Moderately toxic by
subcutaneous route. An experimental
teratogen. Experimental reproductive
effects. An eye irritant. When heated to
decomposition it emits very toxic fumes of
NOx, SOx, and ZnO. Used as an anti-
dandruff agent in shampoos. See also ZINC
COMPOUNDS and SULFIDES.
合成
1000 g of sodium pyrithione, 20% aqueous solution (1.34 mmol of sodium pyrithione) was added to a 2L reactor equipped with a mechanical agitator and warmed to 70 °C with stirring. To the solution was added 190 g of 50 % zinc chloride (0.7 mmol of zinc chloride) over 10 minutes. After the completion of the addition, the solution was stirred at 70 °C for one hour, dehydrated and then washed with 500 g of distilled water. The solid thus obtained was dried with a heated-air drier at 70 °C to have a moisture content of less than 0.5 % and ground with a hammer mill to obtain a find powder of zinc pyrithione. The zinc pyrithione thus obtained was 212 g with a yield of 99.5 %.
ピリチオン亜鉛 上流と下流の製品情報
原材料
準備製品