ブロモ酢酸エチル 化学特性,用途語,生産方法
外観
無色〜うすい黄褐色, 澄明の液体
溶解性
エタノール及びアセトンに溶けやすく、水にほとんど溶けない。
用途
農薬中間体、有機合成原料
用途
有機合成原料。
使用上の注意
強催涙性、刺激性。
化学的特性
Ethyl bromoacetate is a clear, colorless to light-yellow liquid and has a pungent odor. It is miscible with ethanol, ether, benzene and with other oxygenated and aromatic solvents, insoluble in water and partially decomposed by water.
主な応用
Ethyl Bromoacetate is used as a synthetic organic chemical intermediate as well as a pharmaceutical and agricultural intermediate. It is used in the synthesis of metabolites of carcinogenic PAHs. It is also used in the preparation of steroidal antiestrogens through cyclic condensation. Ethyl Bromoacetate is a reactant in the preparation of antim icrobial and antioxidant coumarinyloxymethyl-thiadiazolone.
製造方法
Ethyl bromoacetate is commonly synthesized by sulfuric acid catalyzed esterification of monobromoacetic acid (MBAA). After reaction completion, excess acid is washed out and the product purified via distillation under reduced pressure if necessary (Stenger, 1978; Korhonen, 1984).
反応性
Ethyl bromoacetate on derivatisation reaction with p-t-butyl calix[4]arene yields 1,3-diester substituted calix[4]arene. It also undergoes Suzuki type cross-coupling reactions with arylboronic acids cocatalyzed by copper(I) oxide.
一般的な説明
Ethyl bromoacetate appears as a clear, colorless liquid. A lachrymator. Toxic by ingestion, inhalation and skin absorption; a strong irritant of the skin. Insoluble in water and soluble in alcohol, benzene, and ether. Specific gravity of 1.5.
空気と水の反応
Flammable. Insoluble in water.
反応プロフィール
Ethyl bromoacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
危険性
Toxic by ingestion, inhalation, and skin
absorption; strong irritant.
健康ハザード
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
火災危険
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
安全性プロファイル
A poison. An irritant to
skin, eyes, and mucous membranes.
Questionable carcinogen with experimental
neoplastigenic data. Flammable liquid when
exposed to heat, flame, and oxidizers. Will
react with water or steam to produce toxic
and corrosive fumes. To fight fire, use water
as a fire blanket. When heated to
decomposition or on contact with acid or
acid fumes, it emits highly toxic fumes of
Br-. See also BROMIDES.
職業ばく露
Used for making pharmaceuticals; as
a warning gas in poisonous, odorless gasses; as a tear gas
輸送方法
UN1603 Ethyl bromoacetate, Hazard class: 6.1;
Labels: 6.1-Poisonous materials.
純化方法
Wash the ester with saturated aqueous Na2CO3 (three times), 50% aqueous CaCl2 (three times) and saturated aqueous NaCl (twice). Dry with MgSO4, CaCl2 or CaCO3, and distil it. [Beilstein 2 IV 527.] LACHRYMATORY.
不和合性
Vapor may form explosive mixture with
air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides, and reducing agents. Esters are generally incompatible with nitrates. Moisture may cause hydrolysis or other forms of decomposition.
ブロモ酢酸エチル 上流と下流の製品情報
原材料
準備製品
5-ブロモベンゾフラン-2-カルボン酸エチル
3-アミノベンゾフラン-2-カルボン酸エチル
5-ブロモ-1-ベンゾフラン-2-カルバルデヒド
3-メチルベンゾフラン-2-カルボニルクロライド 塩化物
ethyl 2-(2-aminothiazol-5-ylthio)acetate
3-メチル-2-ベンゾフランカルボン酸エチル
3-O-TOLYL-PROPIONALDEHYDE
2-オキソシクロペンタン酢酸エチル
5-ブロモ-1-ベンゾフラン-2-カルボン酸
2-Phenyl-1H-indole-1-acetic acid ,97%
(R)-(+)-3-アミノキヌクリジン二塩酸塩
3,4-ジメチルチエノ[2,3-B]チオフェン-2-カルボキシアルデヒド
(5-ブロモ-1-ベンゾフラン-2-イル)メタノール
3-(4-クロロフェニル)プロパナール
3,5-DIMETHYL-BENZOFURAN-2-CARBOXYLIC ACID
2-ピペラジノン
ロダニン-3-酢酸
塩化3-クロロフェノキシアセチル
(メチルスルホニル)酢酸エチル
6-ブロモベンゾフラン-2-カルボン酸
4-(TRIFLUOROMETHYL)PHENOXYACETIC ACID
(4-メチルピペラジン-1-イル)酢酸
4-オキソ-5,5,5-トリフルオロ吉草酸メチル
(4-PHENYL-PIPERAZIN-1-YL)-ACETIC ACID
trans-2-オクテン-1-オール
2-メチルシクロプロパンカルボン酸
モルホリン-4-カルボチオアミド
(S)-3-キヌクリジノール
Ethyl(4-butyry-2,3-dichloro)phenoxyacetate
Ethyl 3,5-dimethylbenzofuran-2-carboxylate ,95%
4-クロロ-8-フルオロ-5H-ピリミド[5,4-B]インドール
(4-フルオロフェノキシ)アセチルクロリド
2-[(カルボキシメチル)オキシ]安息香酸
2-フェニル-1H-インドール-1-酢酸エチル
3,3-ジエトキシプロピオン酸エチル
ベンゾフラン-3(2H)-オン
ETHYL 2-(5-FORMYL-2,4-DIMETHYL-1H-PYRROL-3-YL)ACETATE
1-アザビシクロ[2.2.2]オクタン-3-カルボン酸
3,7-ジメチル-2,6-オクタジエン酸
(R)-(-)-3-キヌクリジノール塩酸塩