ヘチサン-2α,3β,9,15β-テトラオール2-ベンゾアート 化学特性,用途語,生産方法
説明
This aconitine alkaloid is present in several A conitum species indigenous to
Japan, e.g. Aconitum calliantum Koidzumi, A. grossedentatum, Nakai, A.
hakusanense Nakai, A. kamtschaticum Willd. et Reichb., A. lucidusculum Nakai,
A. senanense Nakai, A. subcuneatum Nakai, A. tortuosum Willd. and A. Zuccarini
Nakai. It yields clusters of colourless needles when crystallized from Me2COMeOH and gives a form, m.p. 172-4 °c in addition to the one having the above
melting point. It is dextrorotatory with [α]
29D~} + 85.27° (MeOH), or [α]
14D +
92.98°. Crystalline salts of the alkaloid have been prepared, e.g. the hydrochloride, m.p. 245-6°C (dec.); hydrobromide, m.p. 260-2°C (dec.) and the
nitrate which crystallizes as the monohydrate, m.p. 220-2°C (dec. dry). Alkaline
hydrolysis furnishes benzoic acid and hydroignavinol, C20H2S04N, m.p. 302°C.
参考文献
Ochiai et al., J. Pharm. Soc., Japan, 72, 816 (1952)
Ochiai et al., ibid, 76, 550 (1956)
Ochiai", Okamoto, Sasaki., ibid, 75,545 (1955)
Ochiai et al., Chem. Pharm. Bull., 6,327 (1958)
Ochiai et al., ibid, 8, 976 (1960)
Pelletier., Tetrahedron, 14,103 (1961)
ヘチサン-2α,3β,9,15β-テトラオール2-ベンゾアート 上流と下流の製品情報
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