4'-ヒドロキシアセトフェノン 化学特性,用途語,生産方法
外観
白色～わずかにうすい褐色, 結晶～粉末
定義
本品は、次の化学式で表される有機化合物である。
溶解性
水に可溶。エタノールに溶けやすく、水に溶けにくい。
用途
有機合成原料。
化粧品の成分用途
酸化防止剤
使用上の注意
不活性ガス封入
化学的特性
almost white to beige crystalline powder
天然物の起源
Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort.
使用
4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.
製造方法
Preparation by Fries rearrangement of phenyl acetate with Lewis acids
aluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.
定義
ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.
一般的な説明
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
純化方法
Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]
4'-ヒドロキシアセトフェノン 上流と下流の製品情報
原材料
準備製品