4-ビフェニリルアミン

4-ビフェニリルアミン 化学構造式
92-67-1
CAS番号.
92-67-1
化学名:
4-ビフェニリルアミン
别名:
キセニルアミン;4-アミノビフェニル;ビフェニル-4-アミン;4-アミノ-1,1'-ビフェニル;4-フェニルアニリン;4-ビフェニルアミン;キセニラミン;[1,1'-ビフェニル]-4-アミン;p-フェニルアニリン;1,1'-ビフェニル-4-アミン;4-アミノ[1,1'-ビフェニル];4-アミノジフェニル;4-ビフェニリルアミン;ビフェニルアミン;4アミノビフェニル;4-アミノジフェニル及びその塩;4-アミノビフェニルおよびその塩類;4-ビフェニルアミン(4-アミノビフェニル、4-アミノジフェニル);アゾ化合物(分解により特定アミンを生ずる恐れのあるもの)及び特定アミン;ビフェニル-4-イルアミン
英語名:
4-Aminobiphenyl
英語别名:
4-Aminodiphenyl;4-PHENYLANILINE;[1,1'-BIPHENYL]-4-AMINE;4-adp;BIPHENYL-4-AMINE;biphenyl-4-ylamine;4-AMINOBIPHENYL, 100MG, NEAT;Of PCB;NSC 7660;Xenylamin
CBNumber:
CB7229899
化学式:
C12H11N
分子量:
169.22
MOL File:
92-67-1.mol

4-ビフェニリルアミン 物理性質

融点 :
52-54 °C(lit.)
沸点 :
191 °C15 mm Hg(lit.)
比重(密度) :
1.1154 (rough estimate)
蒸気圧:
6 x 10-5 mmHg at 20–30 °C (quoted, Mercer et al., 1990)
屈折率 :
1.5785 (estimate)
闪点 :
>110°C
貯蔵温度 :
-20°C Freezer
溶解性:
ジクロロメタン、DMSO、メタノールに可溶
酸解離定数(Pka):
4.35(at 18℃)
外見 :
色:
ブラウンからダークイエロー
水溶解度 :
20~30℃で 842 mg/L (Mercer et al., 1990 から引用)
Merck :
13,1235
BRN :
386533
Henry's Law Constant:
(x 1010 atm?m3/mol): 3.89 at 25 °C (calculated, Mercer et al., 1990)
安定性::
安定ですが、空気中の酸素とゆっくりと反応します。可燃性。強力な酸化剤、酸、酸無水物、酸塩化物とは相容れない。
InChIKey:
DMVOXQPQNTYEKQ-UHFFFAOYSA-N
CAS データベース:
92-67-1(CAS DataBase Reference)
IARC:
1 (Vol. 1, Sup 7, 99, 100F) 2012
NISTの化学物質情報:
4-Aminobiphenyl(92-67-1)
EPAの化学物質情報:
4-Aminobiphenyl (92-67-1)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,Xn
Rフレーズ  45-22-36/37/38-20/21/22
Sフレーズ  53-45-36-26
RIDADR  UN 3077 9/PG 3
WGK Germany  3
RTECS 番号 DU8925000
自然発火温度 842 °F
TSCA  Yes
国連危険物分類  6.1(a)
容器等級  I
HSコード  29214990
有毒物質データの 92-67-1(Hazardous Substances Data)
毒性 Acute oral LD50 for rats 200 mg/kg, mice 50 mg/kg (quoted, Verschueren, 1983).
消防法 危-4-1-S-II
安衛法 57-2
PRTR法 1-13
毒劇物取締法 II
絵表示(GHS) GHS hazard pictogramsGHS hazard pictograms
注意喚起語 危険
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H302 飲み込むと有害 急性毒性、経口 4 警告 GHS hazard pictograms P264, P270, P301+P312, P330, P501
H350 発がんのおそれ 発がん性 1A, 1B 危険 GHS hazard pictograms
注意書き
P201 使用前に取扱説明書を入手すること。
P202 全ての安全注意を読み理解するまで取り扱わないこ と。
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P301+P312 飲み込んだ場合:気分が悪い時は医師に連絡する こと。
P308+P313 暴露または暴露の懸念がある場合:医師の診断/手当てを 受けること。

4-ビフェニリルアミン 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
関東化学株式会社(KANTO) 49879-10 4‐アミノビフェニル標準液
4‐Aminobiphenyl standard solution
92-67-1 1mL ¥10000 2024-03-01 購入
関東化学株式会社(KANTO) 49863-22 4‐アミノビフェニル標準液
4‐Aminobiphenyl standard solution
92-67-1 10mL ¥25000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) 31598 4-アミノビフェニル analytical standard
analytical standard
92-67-1 250mg ¥12500 2024-03-01 購入

4-ビフェニリルアミン 化学特性,用途語,生産方法

用途

発がん性のため、産業的利用は行われなくなった。かつては染料の合成中間体として、あるいは硫酸塩の検出試薬として使われていた。

説明

4-Aminobiphenyl is an aromatic amine (arylamine) that exists at room temperature as a colorless crystalline solid with a floral odor. It is slightly soluble in cold water, but readily soluble in hot water. It is soluble in ethanol, ether, acetone, chloroform, and lipids. It oxidizes in air and emits toxic fumes when heated to decomposition (Akron 2009).

物理的性質

Colorless to yellow-brown crystalline solid with a floral-like odor. Becomes purple on exposure to air.

使用

In the United States, 4-aminobiphenyl now is used only in laboratory research. It formerly was used commercially as a rubber antioxidant, as a dye intermediate, and in the detection of sulfates (HSDB 2009).

定義

ChEBI: 4-Aminobiphenyl is an aminobiphenyl that is biphenyl substituted by an amino group at position 4. It has a role as a carcinogenic agent. It derives from a hydride of a biphenyl.

一般的な説明

Colorless to yellowish-brown crystals or light brown solid.

空気と水の反応

Is oxidized by air (darkens on oxidation). Insoluble in water.

反応プロフィール

4-AMINOBIPHENYL is a weak base. Incompatible with acids and acid anhydrides. Forms salts with hydrochloric acid and sulfuric acid. Can be diazotized, acetylated and alkylated. . May react with strong oxidizing agents.

危険性

Toxic by ingestion, inhalation, skin absorp- tion. Confirmed carcinogen. Bladder and liver can- cer.

健康ハザード

4-Aminodiphenyl exposure is associated with a high incidence of bladder cancer in humans.

火災危険

4-AMINOBIPHENYL is probably combustible.

安全性プロファイル

Confirmed human carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. An irritant. Effects resemble those of benzidine. See also BENZIDINE. Slight to moderate fire hazard when exposed to heat, flames (sparks), or powerful oxidzers. To fight fire, use water spray, mist, dry chemical. When heated to decomposition it emits toxic fumes of NOx,. See also AROMATIC AMINES.

職業ばく露

4-Aminobiphenyl is no longer manufactured commercially and is only used for research purposes. 4-Aminobiphenyl was formerly used as a rubber antioxidant and as a dye intermediate. Is a contaminant in 2-aminobiphenyl.

発がん性

4-Aminobiphenyl is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.
Cancer of the urinary bladder was first reported to be associated with occupational exposure to 4-aminobiphenyl in a descriptive epidemiological study (published in the mid 1950s), in which 11% (19 of 171) of workers in a plant manufacturing 4-aminobiphenyl developed urinary-bladder cancer. These workers had been exposed to 4-aminobiphenyl for 1.5 to 19 years between 1935 and 1955. Publication of this study led to an effort to discontinue production and useof 4-aminobiphenyl. Starting in 1955, 541 workers who had been exposed to 4-aminobiphenyl were followed for an additional 14 years; 43 men (7.9%) developed histologically confirmed urinary-bladder cancer. In a survey of workers at a plant producing a variety of chemicals, the risk of mortality from urinary-bladder cancer was elevated tenfold, and all of the men who died of urinary-bladder cancer had worked at the plant during the period when 4-aminobiphenyl was used (1941 through 1952). The International Agency for Research onCancer concluded that there was sufficient evidence of the carcinogenicity of 4-aminobiphenyl in humans (IARC 1972, 1987).
Since 4-aminobiphenyl was listed in the First Annual Report on Carcinogens, most research on its carcinogenicity has focused on exposure from cigarette smoking. Epidemiological studies have reported the incidence of urinary-bladder cancer to be 2 to 10 times as high among cigarette smokers as among nonsmokers. Higher levels of 4-aminobiphenyl adducts (4-aminobiphenyl metabolites bound to DNA or protein) were detected in bladder tumors (DNA adducts) and red blood cells (hemoglobin adducts) from smokers thanfrom nonsmokers (Feng et al. 2002). In a case-control study, levels of 4-aminobiphenyl–hemoglobin adducts were higher in smokers with urinary-bladder cancer than in a control group of similarly exposed smokers (Del Santo et al. 1991). A Taiwanese study reported that 4-aminobiphenyl–hemoglobin adducts were associated with increased risk of liver cancer (Wang et al. 1998).

環境運命予測

4-Aminobiphenyl is one of a number of chemicals that cause methemoglobinemia, or conversion of hemoglobin to methemoglobin, which reduces the ability of the blood to carry oxygen to the tissues. In addition, the active metabolite is believed to produce cancer through its reaction with cellular DNA. In animal studies, the observed incidence of 4-aminobiphenyl adducts with bladder epithelium DNA correlated well with the observed bladder tumor incidence.

代謝経路

Ring oxidation of 4-aminobiphenyl occurred only to a minor extent in microsomes. In contrast, N-oxidation of 4,4'-methylene-bis-(2-chloroaniline) is preferentially catalyzed by the phenobarbital-induced enzymes P- 450PB-B and P-450PB-D to cause ring oxidation and methylene carbon oxidation. 4,4'-Methylene-bis-(2- chloroaniline) ring oxidation and methylene carbon oxidation show varied cytochrome P-450 selectivity and accounted for 14-79% of total oxidation products.

輸送方法

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

純化方法

Crystallise it from water or EtOH. [Beilstein 12 IV 3241.] CARCINOGENIC.

不和合性

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides and acid anhydrides.

廃棄物の処理

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal devices.

4-ビフェニリルアミン 上流と下流の製品情報

原材料

準備製品


4-ビフェニリルアミン 生産企業

Global( 251)Suppliers
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4-ビフェニリルアミン  スペクトルデータ(1HNMR、IR1、IR2、MS)


92-67-1(4-ビフェニリルアミン)キーワード:


  • 92-67-1
  • AKOS BBS-00000786
  • 4-BIPHENYLAMINE
  • 4-BIPHENYLYLAMINE
  • 4-AMINOBIPHENYL
  • 4-phenylbenzenamine
  • 4-AMINOBIPHENYL OEKANAL, 250 MG
  • LABOTEST-BB LTBB000626
  • BIPHENYL-4-YLAMINE HYDROCHLORIDE
  • PARA-AMINOBIPHENYL
  • PARA-PHENYLANILINE
  • 4-aminodifenil (spanish)
  • biphenyl-4-ylamine xenylamine 4-aminobiphenyl
  • (1,1'-Biphenyl-4-yl)amine
  • NSC 7660
  • 4-Biphenylamine, 4-Biphenylylamine, 4-Phenylaniline
  • 4-Aminobiphenyl 100mg [92-67-1]
  • 4-Aminobiphenyl ,97%
  • 4-Aminobifenyl
  • 4-aminobiphenyle
  • 4-Aminodifenil
  • 4-Bifenylamin
  • Aniline, p-phenyl-
  • Biphenylamine
  • p-Aminobiphenyl
  • p-Aminodiphenyl
  • Paraaminodiphenyl
  • para-aminodiphenyl
  • p-Biphenylamine
  • p-Phenylaniline
  • p-Xenylamine
  • キセニルアミン
  • 4-アミノビフェニル
  • ビフェニル-4-アミン
  • 4-アミノ-1,1'-ビフェニル
  • 4-フェニルアニリン
  • 4-ビフェニルアミン
  • キセニラミン
  • [1,1'-ビフェニル]-4-アミン
  • p-フェニルアニリン
  • 1,1'-ビフェニル-4-アミン
  • 4-アミノ[1,1'-ビフェニル]
  • 4-アミノジフェニル
  • 4-ビフェニリルアミン
  • ビフェニルアミン
  • 4アミノビフェニル
  • 4-アミノジフェニル及びその塩
  • 4-アミノビフェニルおよびその塩類
  • 4-ビフェニルアミン(4-アミノビフェニル、4-アミノジフェニル)
  • アゾ化合物(分解により特定アミンを生ずる恐れのあるもの)及び特定アミン
  • ビフェニル-4-イルアミン
  • 4‐アミノビフェニル標準液
  • 4-アミノ-1,1′-ビフェニル
  • [1,1′-ビフェニル]-4-アミン
  • 1,1′-ビフェニル-4-アミン
  • 4-アミノ[1,1′-ビフェニル]
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