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2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-

化学構造式
865305-30-2
CAS番号.
865305-30-2
化学名:
别名:
英語名:
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
英語别名:
Ro 4;AF 353;CS-2469;CHEMBL526307;AF-353 (Ro-4);CHEMBL526307;AF 353;AF353;5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine;Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353;5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine;2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
CBNumber:
CB72609596
化学式:
C14H17IN4O2
分子量:
400.21
MOL File:
865305-30-2.mol

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- 物理性質

沸点 :
510.2±60.0 °C(Predicted)
比重(密度) :
1.619±0.06 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
DMSO : ≥ 32 mg/mL (79.96 mM)
酸解離定数(Pka):
6.89±0.10(Predicted)

安全性情報

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- 化学特性,用途語,生産方法

説明

AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- 上流と下流の製品情報

原材料

準備製品

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- 生産企業

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  スペクトルデータ(1HNMR)

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-(865305-30-2)1HNMR
  • 865305-30-2
  • 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
  • AF 353
  • Ro 4
  • 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine
  • AF-353 (Ro-4)
  • 5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
  • 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride Ro 4 hydrochloride
  • CS-2469
  • CHEMBL526307;AF 353;AF353
  • CHEMBL526307
  • 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine
  • Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353
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