レンボレキサント

レンボレキサント 価格

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入

レンボレキサント 化学特性,用途語,生産方法

効能

催眠薬, オレキシン受容体拮抗薬

説明

Lemborexant is a newer orexin receptor antagonist which is submitted to US FDA for review as new drug application for the treatment of insomnia after completing two key Phase 3 studies of lemborexant – SUNRISE 1 (Study 304) and SUNRISE 2 (Study 303).

化学的特性

Lemborexant is a white to off-white powder that is practically insoluble in water.

使用

Lemborexant is a novel orexin receptor antagonist and is used in the treatment of insomnia, characterised by difficulties with sleep onset or sleep maintenance. Orexins are neuropeptides involved in regulating sleep and arousal by promoting wakefulness. Lemborexant blocks the binding of orexins A and B to their receptors 1 and 2 thereby reducing wakefulness and promoting sleep. Suvorexant is the other orexin receptor antagonist marketed in Australia for insomnia.

薬物動態学

薬物相互作用

Lemborexant is metabolized by CYP3A4 and is susceptible to interactions with medications such as amiodarone, amlodipine, carbamazepine, clarithromycin, diltiazem, fluoxetine and phenytoin. Lemborexant may affect other medications metabolised by CYP2B6, such as bupropion and methadone. Alcohol should be avoided: a single dose of alcohol can increase lemborexant concentrations up to 70%.

Mode of action

The mechanism of action of lemborexant in the treatment of insomnia is Blocks the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R, presumed to suppress wake drive.

参考文献

https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212028s000lbl.pdf
https://www.smchealth.org/sites/main/files/file-attachments/dayvigo_for_publish.pdf?1592332002
https://www.superiorhealthplan.com/content/dam/centene/Superior/policies/pharmacy-policies/Lemborexant%20(Dayvigo)%20(CP.PMN.233)%20(PDF).pdf

レンボレキサント 上流と下流の製品情報

原材料

準備製品

レンボレキサント 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12471	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Shochem(Shanghai) Co.,Ltd	86-21-50800795	info@shochem.com	CHINA	288	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Chengdu Feibo Pharm Technology Co., Ltd	15982321820	abby@arkpharm.com	CHINA	3279	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28404	58

1369764-02-2(レンボレキサント)キーワード:

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• 1369764-02-2
• (1R,2S)-2-[[(2,4-Dimethyl-5-pyrimidinyl)oxy]methyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)cyclopropanecarboxamide
• E 2006
• Lemborexant
• lemborexant,E2006
• (1R,2S)-2-[(2,4-DIMETHYLPYRIMIDIN-5-YL)OXYMETHYL]-2-(3-FLUOROPHENYL)-N-(5-FLUOROPYRIDIN-2-YL)CYCLOPROPANE-1-CARBOXAMIDE
• lemborexant / E-2006, CID 56944144
• E-2006 Lemborexant
• 2-((1S,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)cyclopropyl)-N-(5-fluoropyridin-2-yl)acetamide
• CS-2189
• Dayvigo.
• E-2006; E 2006; E2006; LEMBOREXANT; DAYVIGO.
• Cyclopropanecarboxamide, 2-[[(2,4-dimethyl-5-pyrimidinyl)oxy]methyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)-, (1R,2S)-
• Lemborexant USP/EP/BP
• Lemborexant Impurity 1
• Lemborexant API
• labradon
• レンボレキサント
• レンボレキサント (JAN)
• (1R,2S)-2-{[(2,4-ジメチルピリミジン-5-イル)オキシ]メチル}-2-(3-フルオロフェニル)-N-(5-フルオロピリジン-2-イル)シクロプロパン-1-カルボキサミド
• (1R,2S)-N-(5-フルオロピリジン-2-イル)-2α-(3-フルオロフェニル)-2-(2,4-ジメチルピリミジン-5-イルオキシメチル)シクロプロパン-1β-カルボアミド
• (1R)-N-(5-フルオロ-2-ピリジニル)-2β-(2,4-ジメチル-5-ピリミジニルオキシメチル)-2-(3-フルオロフェニル)シクロプロパン-1β-カルボアミド
• デエビゴ錠