P450 3A4

 化学構造式
CAS番号.
化学名:
别名:
英語名:
P450 3A4
英語别名:
CYP3A4;P450 3A4;CYP3A4 HR (HUMAN);CYTOCHROME P450 3A4;CYTOCHROME P450 3A4 (HUMAN);CYTOCHROME P450 3A4, HUMAN, RECOMBINANT, E COLI
CBNumber:
CB7287015
化学式:
分子量:
0
MOL File:
Mol file

P450 3A4 物理性質

貯蔵温度 :
-70°C

安全性情報

P450 3A4 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

P450 3A4 化学特性,用途語,生産方法

説明

The CYP3A subfamily includes the most abundantly expressed CYP450s in the human liver and intestine (extrahepatic metabolism). Although CYP3A4 is responsible for approximately two-thirds of CYP3A-mediated drug metabolism, the other minor isoforms (CYP3A5, CYP3A7, and CYP3A43) also contribute. The CYP3A5 is the best studied of the minor CYP3A isoforms. Approximately 20% of human livers express CYP3A5. The expression of CYP3A5 shows interethnic differences, with the wild-type CYP3A5*1 allele being more common in Africans than in Caucasians and Asians. In individuals who express CYP3A5, 17 to 50% of the total hepatic CYP3A is this isoform. Additionally, CYP3A5 also is expressed in a range of extrahepatic tissues and is inducible via pregnane X receptor. Both CYP3A4 and CYP3A5 exhibit significant overlap in substrate specificity but can differ in catalytic activity and regioselectivity. Results from a comparison of CYP3A4 and CYP3A5 enzyme kinetics indicate that CYP3A5 has different enzymic characteristics from CYP3A4 in some CYP3A-catalyzed reactions. The enzyme kinetics for CYP3A5 suggest a faster substrate turnover than with CYP3A4.

生物学の機能

Approximately one-third of the total CYP450 in the liver and two-thirds in the intestine is CYP3A4. This isoform is responsible for the metabolism of more than one-third of the clinically important drugs. The CYP3A4 is expressed in the intestine, lung, placenta, kidney, uterus, and brain and is glucocorticoid inducible. The CYP3A7 is predominantly expressed in fetal liver (~50% of total fetal CYP450 enzymes) but also is found in some adult livers and extrahepatically. The CYP3A7 has a specific role in hydroxylation of retinoic acid, 16α-hydroxylation of steroids, and hydroxylation of allylic and benzylic carbons and, therefore, is of relevance both to normal development and to carcinogenesis. The most recently discovered CYP3A isoform is CYP3A3. In addition to a low level of expression in liver, it is expressed in prostate and testis. Its substrate specificity currently is unclear. Polymorphisms predicting absence of active enzyme have been identified.

P450 3A4 上流と下流の製品情報

原材料

準備製品


P450 3A4 生産企業

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