塩酸 パパベリン

塩酸 パパベリン 化学構造式
61-25-6
CAS番号.
61-25-6
化学名:
塩酸 パパベリン
别名:
塩酸 パパベリン;パパベリン塩酸塩;塩パパ;1-[(3,4-ジメトキシフェニル)メチル]-6,7-ジメトキシイソキノリン·塩酸塩;パパベリン·塩酸塩;塩酸パパベリン;6,7-ジメトキシ-1-(3,4-ジメトキシベンジル)イソキノリン塩酸塩;パパベリン 塩酸塩;パパベリン塩酸塩, 99%;パパベリン塩酸塩 (JP17)
英語名:
Papaverine hydrochloride
英語别名:
PAPAVERINE HCL;paph;dipav;BOC-azide;1-(3,4-DIMETHOXYBENZYL)-6,7-DIMETHOXYISOQUINOLINE HYDROCHLORIDE;lapav;vasal;dynovas;optenyl;pameion
CBNumber:
CB7689772
化学式:
C20H22ClNO4
分子量:
375.85
MOL File:
61-25-6.mol

塩酸 パパベリン 物理性質

融点 :
226°C (dec.)
貯蔵温度 :
Amber Vial, Refrigerator
溶解性:
H2O: 25 mg/mL
外見 :
色:
白い
PH:
pH (20g/l, 25℃) : 3.0~4.0
水溶解度 :
溶けやすい
Sensitive :
Light Sensitive
Merck :
14,7019
BRN :
3921435
安定性::
安定していますが、光に敏感な場合があります。
CAS データベース:
61-25-6(CAS DataBase Reference)
EPAの化学物質情報:
Papaverine hydrochloride (61-25-6)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  Xn,C,F
Rフレーズ  22-34-11
Sフレーズ  22-45-36/37/39-26-16
RIDADR  UN 1544 6.1/PG 3
WGK Germany  1
RTECS 番号 NW8575000
8
TSCA  Yes
国連危険物分類  6.1
容器等級  III
HSコード  29391900
毒性 LD50 in mice, rats (mg/kg): 27.5, 20 i.v.; 150, 370 s.c. (Levis)
化審法 (5)-827
絵表示(GHS) GHS hazard pictograms
注意喚起語 危険
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
注意書き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P270 この製品を使用する時に、飲食または喫煙をしないこ と。
P301+P310 飲み込んだ場合:直ちに医師に連絡すること。
P405 施錠して保管すること。
P501 内容物/容器を...に廃棄すること。

塩酸 パパベリン 価格 もっと(30)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCP190500 パパベリン塩酸塩
Papaverine Hydrochloride
61-25-6 5g ¥26400 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01USP1496008 パパベリン塩酸塩
Papaverine Hydrochloride
61-25-6 200mg ¥91400 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCP190500 パパベリン塩酸塩
Papaverine Hydrochloride
61-25-6 25g ¥74700 2024-03-01 購入
東京化成工業 P0016 パパベリン塩酸塩 >99.0%(HPLC)
Papaverine Hydrochloride >99.0%(HPLC)
61-25-6 25g ¥3800 2024-03-01 購入
関東化学株式会社(KANTO) 49868-58 パパベリン塩酸塩
Papaverine hydrochloride
61-25-6 100mg ¥39000 2024-03-01 購入

塩酸 パパベリン MSDS


Papaverine hydrochloride

塩酸 パパベリン 化学特性,用途語,生産方法

外観

白色~ほとんど白色, 結晶性粉末~粉末

溶解性

水にやや溶けにくく、エタノールに溶けにくく、アセトンにほとんど溶けない。水、エタノール、クロロホルムに可溶。エーテルにほとんど不溶。

用途

ホスホジエステラーゼ阻害作 用を示します。

用途

ホスホジエステラーゼ阻害作 用を示します。

効能

鎮痙薬, 平滑筋弛緩薬, 血管拡張薬, ホスホジエステラーゼ阻害薬

商品名

パパベリン塩酸塩 (日医工)

説明

Papaverine Hydrochloride, USP, is the hydrochloride of an alkaloid obtained from opium or prepared synthetically. It belongs to the benzylisoquinoline group of alkaloids. It does not contain a phenanthrene group as do morphine and codeine.
Papaverine Hydrochloride, USP, is 6,7-dimethoxy-1-veratrylisoquinoline hydrochloride and contains, on the dried basis, not less than 98.5% of CHNO.HCI. The molecular weight is 375.85. The structural formula is as shown.
Papaverine Hydrochloride occurs as white crystals or white crystalline powder. One gram dissolves in about 30 mL of water and in 120 mL of alcohol. It is soluble in chloroform and practically insoluble in ether.
Papaverine Hydrochloride Injection, USP, is a clear, colorless to pale-yellow solution.
Papaverine Hydrochloride, for parenteral administration, is a smooth-muscle relaxant that is available in vials containing 30 mg/mL. Each vial also contains edetate disodium 0.005%. The 10 mL vials also contain chlorobutanol 0.5% as a preservative. pH may be adjusted with sodium citrate and/or citric acid.

化学的特性

PAPAVERINE HYDROCHLORIDE is Crystalline Solid

物理的性質

Appearance: colorless prismatic or acicular crystal. Melting point: 147–148? °C. Relative density: 1.337 (20/4?°C). Solubility: very soluble in benzene, acetone, hot ethanol, and glacial acetic acid; soluble in concentrated sulfuric acid; slightly soluble in ether, chloroform, and carbon tetrachloride; and insoluble in water. The common crystalline salt is hydrochloride salt, papaverine hydrochloride.

来歴

Human beings have a long history of using opium poppy as food and narcotics, which can be dated back to the Neolithic age. The opium, which is the dried product of the opium poppy juice, is widely used as analgesics in the old and new civilizations of the old continent except the Chinese civilization.
In 1848, German chemist Georg Merck successfully isolated a new alkaloid from the opium liquor for the first time and named it as “papaverine” . He also determined the correct molecular formula of papaverine as C20 H21NO4 and prepared the papaverine hydrochloride and nitrate by recrystallization method. Then, Goldschmiedt et?al. put forward the molecular structure of papaverine by studying its oxidation products in 1883 and determined the isoquinoline ring as the core structure of papaverine in 1888 .
Since the content of papaverine in plants is very low (less than 1%) and can hardly meet the clinical needs, so Pictet and Gams proposed a synthetic method of papaverine in 1909, which makes the large-scale industrialized production of papaverine possible .
Study on the pharmacology of papaverine was first published in 1914 by Professor Pal of Vienna, who found that papaverine possessed smooth muscle relaxation effect without causing smooth muscle paralysis and can be used for the treatment of hypertension, angina, and acute uremia .

使用

Papaverine hydrochloride is as effective as sodium diclofenac for the short-term relief of acute renal colic pain and may be advantageous in patients with contraindications for nonsteroidal anti-inflammatory drugs. However, sodium diclofenac appears to provide a longer effective analgesia.
Papaverine hydrochloride belongs to the group of benzylisoquinoline alkaloid. It is obtained from opium poppy.
Papaverine hydrochloride has been used:
in oxygenated Krebs solution for tissue mechanics analysis
as a vasodilator in heparinized horse serum in tissue uptake technique
as an inhibitor of H-MPP+ uptake into stably transfected 293 cells expressing either extraneuronal monoamine transporter (EMT) human or EMT rat

適応症

Papaverine is mainly used for the treatment of ischemia caused by cerebral, cardiac, and peripheral vascular spasm, as well as visceral spasm of the kidney, gallbladder, or gastrointestinal tract.

一般的な説明

Papaverine hydrochloride,6,7-dimethoxy-1-veratrylisoquinoline hydrochloride,was isolated by Merck in 1848 from opium,in which it occurs to the extent of about 1%. Althoughits natural origin is closely related to morphine, the pharmacologicalactions of papaverine hydrochloride areunlike those of morphine. Its main effect is as a spasmolyticon smooth muscle, acting as a direct, nonspecificrelaxant on vascular, cardiac, and other smooth muscle.Because of its broad antispasmodic action on ACh muscarinicreceptors, it is often called a nonspecific antagonist.Papaverine hydrochloride has been used in the treatmentof peripheral vascular disorders, but its use is limitedby lack of potency.
Papaverine hydrochloride interferes with the mechanismof muscle contraction by inhibiting the cyclic nucleotidephosphodiesterases in smooth muscle cells responsible forconverting cAMP and cyclic guanosine monophosphate(cGMP) to 5' -AMP and 5' -GMP, respectively. The increasedlevels of cAMP and cGMP are associated with muscle relaxation through their phosphorylation of myosinlight-chain kinase.

空気と水の反応

Water soluble.

反応プロフィール

Papaverine hydrochloride is sensitive to light. .

健康ハザード

SYMPTOMS: Symptoms of exposure to Papaverine hydrochloride may include sleepiness, slowed respiration and slowed heart beat.

火災危険

Flash point data for Papaverine hydrochloride are not available, but Papaverine hydrochloride is probably combustible.

薬理学

As a vasodilator, papaverine is a nonspecific antispasmodic drug of smooth muscle, which is especially effective on pulmonary artery, coronary artery, and great vessels, producing systemic and nonspecific hypotensive and smooth muscle relaxation effect. Papaverine has a direct effect on the smooth muscle cells by inhibiting phosphodiesterase, thus increasing the intracellular concentration of cyclic adenosine monophosphate (cAMP), which further removes the catalase calcium from cytoplasmic of vascular smooth muscle, leading to the direct smooth muscle relaxation without nerve. Papaverine can also inhibit the cardiac conduction, directly act on myocardial cells, and prolong the refractory period. No effect of papaverine on the central nervous system has been found. High dose of papaverine can cause hypotension and tachycardia.

臨床応用

Papaverine hydrochloride is used for the treatment of ischemia induced by brain, heart, and peripheral vascular spasm, as well as visceral spasm of the kidney, bladder, or gastrointestinal tract. Besides, papaverine is also suitable for angina and arterial embolism, occasionally used for the treatment of erectile dysfunction. In recent years, papaverine hydrochloride also combines with other drugs like nimodipine to treat the vasospasm and crisis triggered by subarachnoid hemorrhage and calculi-induced acute renal colic. The main adverse effects of papaverine include liver function damage, exaggerated respiration induced by rapid parenteral administration, facial flushing, heart rate acceleration, as well as hypotension with vertigo. In addition, overdose of papaverine can lead to blurred vision, diplopia, lethargy, and weakness.

安全性プロファイル

Poison by ingestion, intraperitoneal, intraduodenal, intravenous, and subcutaneous routes. Human systemic effects: metabolic acidosis, pulse rate increase. An experimental teratogen. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. See also PAPAVERINE

純化方法

Recrystallise it from H2O. It sublimes at 140o/0.1mm. Its solubility in H2O is 5%. [Saunders & Srivastava J Pharm Pharmacol 3 78 1951, Biggs Trans Faraday Soc 50 800 1954.] The free base has m 148-150o, The picrate has m 186-189o(dec, 186-186.5o(dec) [Bobbitt J Org Chem 22 1729 1957]. [Beilstein 21 II 202, 21 III/IV 2788, 21/6 V 182.]

塩酸 パパベリン 上流と下流の製品情報

原材料

準備製品


塩酸 パパベリン 生産企業

Global( 218)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Shanxi Naipu Import and Export Co.,Ltd
+86-13734021967 +8613734021967
kaia@neputrading.com China 1011 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387
1057@dideu.com China 3979 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10326 58
Longyan Tianhua Biological Technology Co., Ltd
0086 18039857276 18039857276
CHINA 2783 58
Shanghai UCHEM Inc.
+862156762820 +86-13564624040
sales@myuchem.com China 6645 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9802 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29831 58


61-25-6(塩酸 パパベリン)キーワード:


  • 61-25-6
  • Papaverine hydrochloride, 99% 5GR
  • papaverine hydrochloride:6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-isoQUINOLINE hydrochloride: 1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoQUINOLINE hydrochloride
  • Papaverine hydrochloride,99%
  • papaverin hydrochloride
  • papaverine hydrochloride 90.2%
  • Papaverine Hydrochloride (200 mg)
  • Isoquinoline,1-[(3,4-diMethoxyphenyl)Methyl]-6,7-diMethoxy-, hydrochloride (1:1)
  • 1-[(3',4'-DIMETHOXYPHENYL)METHYL]-6,7-DIMETHOXYISOQUINOLINE HCL
  • 6,7-DIMETHOXY-1-VERATRYLISOQUINOLINE HCL
  • 6,7-DIMETHOXY-1-VERATRYL-ISOQUINOLINE HYDROCHLORIDE
  • 6,7-DIMETHOXY-1-(3,4-DIMETHOXYBENZYL)-ISOQUINOLINE HYDROCHLORIDE
  • 1,1-Dimethylethyl azidoformate
  • Carbonazidic acid, 1,1-dimethylethyl ester
  • Cardiospan
  • Formic acid, azido-, tert-butyl ester
  • tert-Butyloxycarbonyl azide
  • 1-((3,4-dimethoxyphenyl)methyl)-6,7-dimethoxy-isoquinolinhydrochloride
  • 1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-isoquinolinhydrochloride
  • 6,7,3’,4’-tetramethoxy-1-benzylisoquinolinehydrochloride
  • 6,7-dimethoxy-1-veratryl-isoquinolinhydrochloride
  • artegodan
  • cardoverina
  • cepaverin
  • cerespan
  • chlorhydratedepapaverine
  • dispamil
  • dynovas
  • lapav
  • nci-c56359
  • optenyl
  • 塩酸 パパベリン
  • パパベリン塩酸塩
  • 塩パパ
  • 1-[(3,4-ジメトキシフェニル)メチル]-6,7-ジメトキシイソキノリン·塩酸塩
  • パパベリン·塩酸塩
  • 塩酸パパベリン
  • 6,7-ジメトキシ-1-(3,4-ジメトキシベンジル)イソキノリン塩酸塩
  • パパベリン 塩酸塩
  • パパベリン塩酸塩, 99%
  • パパベリン塩酸塩 (JP17)
  • アルカロイド
  • イソキノリンアルカロイド
  • 生化学
  • コリン作動薬
  • 酵素阻害剤
  • 筋弛緩薬
  • 平滑筋作用薬
  • 血管拡張薬
  • 鎮痙薬
Copyright 2017 © ChemicalBook. All rights reserved