L-アスコルビン酸ナトリウム 化学特性,用途語,生産方法
外観
白色～わずかにうすい黄色, 結晶～結晶性粉末
定義
本品は、アスコルビン酸(*)のナトリウム塩であり、次の化学式で表される。
参照表示名称：アスコルビン酸
溶解性
水に極めて溶けやすく、エタノールに溶けにくい。
用途
還元剤、酸化防止剤、写真用。
化粧品の成分用途
酸化防止剤
効能
壊血病治療薬, ビタミンC補充薬
化学的特性
Sodium ascorbate occurs as a white or slightly yellow-colored,
practically odorless, crystalline powder with a pleasant saline taste.
使用
Sodium Ascorbate is an antioxidant that is the sodium form of
ascorbic acid. it is soluble in water and provides a nonacidic taste. a
10% aqueous solution has a ph of 7.3–7.6. in water, it readily reacts
with atmospheric oxygen and other oxidizing agents, making it
valuable as an antioxidant. one part sodium ascorbate is equivalent
to 1.09 parts of sodium erythorbate. see ascorbic acid.
調製方法
An equivalent amount of sodium bicarbonate is added to a solution
of ascorbic acid in water. Following the cessation of effervescence,
the addition of propan-2-ol precipitates sodium ascorbate.
定義
ChEBI: Sodium ascorbate is an organic sodium salt resulting from the replacement of the proton from the 3-hydroxy group of ascorbic acid by a sodium ion. It has a role as a food antioxidant, a flour treatment agent, a coenzyme, a plant metabolite, a human metabolite, a Daphnia magna metabolite and a reducing agent. It is an organic sodium salt and a vitamin C. It contains a L-ascorbate.
一般的な説明
Minute crystals or white powder. pH of aqueous solutions 5.6 to 7.0 or even higher (a 10% solution, made from a commercial grade, may have a pH of 7.4 to 7.7).
空気と水の反応
Water soluble. Aqueous solutions are subject to quick air oxidation at pH greater than 6.0.
反応プロフィール
A weak base. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydroxide ions and have pH's greater than 7.0. They react as bases to neutralize acids. These neutralizations generate heat, but less or far less than is generated by neutralization of the bases in reactivity group 10 (Bases) and the neutralization of amines. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.
健康ハザード
SYMPTOMS: Ingestion of 10 grams or more of this type of compound may cause diarrhea.
火災危険
Flash point data for Sodium ascorbate are not available. Sodium ascorbate is probably combustible.
応用例（製薬）
Sodium ascorbate is used as an antioxidant in pharmaceutical
formulations, and also in food products where it increases the
effectiveness of sodium nitrite against growth of Listeria monocytogenes
in cooked meats. It improves gel cohesiveness and sensory
firmness of fiberized products regardless of vacuum treatment.
It is also used therapeutically as a source of vitamin C in tablets
and parenteral preparations.
安全性プロファイル
Human mutation data
reported. When heated to decomposition it
emits toxic fumes of Na2O.
安全性
The parenteral administration of 0.25-1.00 g of sodium ascorbate,
given daily in divided doses, is recommended in the treatment of
vitamin C deficiencies. Various adverse reactions have been
reported following the administration of 1 g or more of sodium
ascorbate, although ascorbic acid and sodium ascorbate are usually
well tolerated; see Ascorbic acid. There have been no reports of
adverse effects associated with the much lower concentrations of
sodium ascorbate and ascorbic acid, which are employed as
antioxidants.
The WHO has set an acceptable daily intake of ascorbic acid,
potassium ascorbate, and sodium ascorbate, as antioxidants in
food, at up to 15 mg/kg body-weight in addition to that naturally
present in food.
貯蔵
Sodium ascorbate is relatively stable in air, although it gradually
darkens on exposure to light. Aqueous solutions are unstable and
subject to rapid oxidation in air at pH > 6.0.
The bulk material should be stored in a well-closed nonmetallic
container, protected from light, in a cool, dry place.
不和合性
Incompatible with oxidizing agents, heavy metal ions, especially
copper and iron, methenamine, sodium nitrite, sodium salicylate,
and theobromine salicylate. The aqueous solution is reported to be
incompatible with stainless steel filters.
規制状況(Regulatory Status)
GRAS listed. Accepted for use as a food additive in Europe.
Included in the FDA Inactive Ingredients Database (IV preparations;
oral tablets). Included in nonparenteral and parenteral
medicines licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients.
L-アスコルビン酸ナトリウム 上流と下流の製品情報
原材料
準備製品