りん酸二水素ナトリウム·2水和物

りん酸二水素ナトリウム·2水和物 化学構造式
13472-35-0
CAS番号.
13472-35-0
化学名:
りん酸二水素ナトリウム·2水和物
别名:
りん酸二水素ナトリウム·2水和物;第一燐酸ソ-ダ 2水塩;りん酸二水素ナトリウム二水和物;りん酸一ナトリウム二水和物;ナトリウム ジ水素ホスフェト 二水和物;りん酸一ナトリウム二水和物(りん酸二水素ナトリウム二水和物);りん酸二水素ナトリウム,二水和物りん酸一ナトリウム,2水和物;りん酸二水素ナトリウム(2水和物);リン酸二水素ナトリウム水和物[CERTIPRO:薬添規、USP、PH.EUR.規格適合、エンドトキシン保証];リン酸ナトリウム, 一塩基酸 二水和物;りん酸一ナトリウム二水和物( りん酸二水素ナトリウム二水和物);りん酸二水素ナトリウム二水和物, 99%;りん酸二水素ナトリウム・2水和物
英語名:
Sodium dihydrogen phosphate dihydrate
英語别名:
Sodium dihydrogen orthophosphate;SODIUM BIPHOSPHATE;SODIUM PHOSPHATE, MONOBASIC, DIHYDRATE;SODIUM PHOSPHATE DIHYDRATE;SAMARIUM 1,000PPM;99.0 ~ 101.0%,ACS;Sodium dihydrogen ph;Natriumdihydrogenphosphat;MONO-SODIUM ORTHOPHOSPHATE;SODIUM PHOSPHATE 1BAS 2HYD
CBNumber:
CB8203308
化学式:
NaH2PO4·2H2O
分子量:
140.01
MOL File:
13472-35-0.mol
MSDS File:
SDS

りん酸二水素ナトリウム·2水和物 物理性質

融点 :
60 °C
比重(密度) :
1,915 g/cm3
貯蔵温度 :
Store at +5°C to +30°C.
溶解性:
H2O: 1M at20℃、透明、無色
外見 :
個体
色:
白い
PH:
4.0-4.5 (25℃, 50mg/mL in H2O)
臭い (Odor):
無臭
酸塩基指示薬変色域(pH):
4.2 - 4.5
水溶解度 :
溶ける
Sensitive :
Hygroscopic
極大吸収波長 (λmax):
λ: 260 nm Amax: 0.085
λ: 280 nm Amax: 0.070
Merck :
14,8660
安定性::
安定。
InChIKey:
VBJGJHBYWREJQD-UHFFFAOYSA-M
CAS データベース:
13472-35-0(CAS DataBase Reference)
EPAの化学物質情報:
Phosphoric acid, monosodium salt (13472-35-0)

安全性情報

主な危険性  Xi
Rフレーズ  36-36/37/38
Sフレーズ  39-26-24/25-36
WGK Germany  1
RTECS 番号 WA1900500
TSCA  Yes
HSコード  2835 22 00
毒性 LD50 orally in Rabbit: 8290 mg/kg LD50 dermal Rabbit > 7940 mg/kg

りん酸二水素ナトリウム·2水和物 価格 もっと(52)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01AFAA11316 りん酸二水素ナトリウム二水和物, 99%
Sodium dihydrogen phosphate dihydrate, 99%
13472-35-0 100g ¥8560 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01AFAA11316 りん酸二水素ナトリウム二水和物, 99%
Sodium dihydrogen phosphate dihydrate, 99%
13472-35-0 500g ¥12540 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01AFAA11316 りん酸二水素ナトリウム二水和物, 99%
Sodium dihydrogen phosphate dihydrate, 99%
13472-35-0 2500g ¥37150 2024-03-01 購入
関東化学株式会社(KANTO) 37239-01 りん酸二水素ナトリウム二水和物 98.0%~102.0%(T)
Sodium dihydrogenphosphate dihydrate 98.0%~102.0%(T)
13472-35-0 500g ¥1900 2024-03-01 購入
関東化学株式会社(KANTO) 37239-00 りん酸二水素ナトリウム二水和物 99.0%~102.0%(T)
Sodium dihydrogenphosphate dihydrate 99.0%~102.0%(T)
13472-35-0 500g ¥2100 2024-03-01 購入

りん酸二水素ナトリウム·2水和物 MSDS


Sodium dihydrogen orthophosphate

りん酸二水素ナトリウム·2水和物 化学特性,用途語,生産方法

外観

無色もしくは白色の結晶又は結晶性の粉末

定義

本品は、リン酸(*)のナトリウム塩であり、次の化学式で表される。
参照表示名称:リン酸

溶解性

水に溶けやすく、エタノールにほとんど溶けない。

用途

医薬、製剤原料。

化粧品の成分用途

緩衝剤、消臭剤

使用上の注意

吸湿性がある。

化学的特性

white crystalline solid

使用

Sodium dihydrogen phosphate dihydrate acts as buffering capacity reagent in molecular biology, biochemistry and chromatography. It is used in the preparation of biological buffers. It is also used in the purification of antibodies, as a laxative and, in combination with other sodium phosphates.
Sodium phosphate monobasic dihydrate is a reagent with very high buffering capacity widely used in molecular biology, biochemistry and chromatography. Sodium phosphate dibasic is highly hygroscopic and water soluble.
Recommended chemicals for the preparation of phosphate buffers are sodium dihydrogen phosphate dihydrate,NaH2PO4.2H2O(mol. wt.156.0),disodium hydrogen phosphate dihydrate,Na2HPO4.2H2O (mol. wt.178.0), and sodium hydroxide pellets.

調製方法

Monobasic sodium phosphate is prepared by adding phosphoric acid to a hot, concentrated solution of disodium phosphate until the liquid ceases to form a precipitate with barium chloride. This solution is then concentrated and the monobasic sodium phosphate is crystallized.

応用例(製薬)

Monobasic sodium phosphate is used in a wide variety of pharmaceutical formulations as a buffering agent and as a sequestering agent. Therapeutically, monobasic sodium phosphate is used as a mild saline laxative and in the treatment of hypophosphatemia.
Monobasic sodium phosphate is also used in food products, for example, in baking powders, and as a dry acidulant and sequestrant.

安全性

Monobasic sodium phosphate is widely used as an excipient in parenteral, oral, and topical pharmaceutical formulations.
Phosphate occurs extensively in the body and is involved in many physiological processes since it is the principal anion of intracellular fluid. Most foods contain adequate amounts of phosphate, making hypophosphatemia virtually unknown except in certain disease states or in patients receiving total parenteral nutrition. Treatment is usually by the oral administration of up to 100 mmol of phosphate daily.
Approximately two-thirds of ingested phosphate is absorbed from the gastrointestinal tract, virtually all of it being excreted in the urine, and the remainder is excreted in the feces. Excessive administration of phosphate, particularly intravenously, rectally, or in patients with renal failure, can cause hyperphosphatemia that may lead to hypocalcemia or other severe electrolyte imbalances. Adverse effects occur less frequently following oral consumption, although phosphates act as mild saline laxatives when administered orally or rectally (2–4 g of monobasic sodium phosphate in an aqueous solution is used as a laxative). Consequently, gastrointestinal disturbances including diarrhea, nausea, and vomiting may occur following the use of monobasic sodium phosphate as an excipient in oral formulations. However, the level of monobasic sodium phosphate used as an excipient in a pharmaceutical formulation is not usually associated with adverse effects.
LD50 (rat, IM): 0.25 g/kg(10)
LD50 (rat, oral): 8.29 g/kg

貯蔵

Monobasic sodium phosphate is chemically stable, although it is slightly deliquescent. On heating at 100°C, the dihydrate loses all of its water of crystallization. On further heating, it melts with decomposition at 205℃, forming sodium hydrogen pyrophosphate, Na2H2P2O7. At 250℃ it leaves a final residue of sodium metaphosphate, NaPO3.
Aqueous solutions are stable and may be sterilized by autoclaving.
Monobasic sodium phosphate should be stored in an airtight container in a cool, dry place.

不和合性

Monobasic sodium phosphate is an acid salt and is therefore generally incompatible with alkaline materials and carbonates; aqueous solutions of monobasic sodium phosphate are acidic and will cause carbonates to effervesce.
Monobasic sodium phosphate should not be administered concomitantly with aluminum, calcium, or magnesium salts since they bind phosphate and could impair its absorption from the gastrointestinal tract. Interaction between calcium and phosphate, leading to the formation of insoluble calcium phosphate precipitates, is possible in parenteral admixtures.

規制状況(Regulatory Status)

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections; infusions; ophthalmic, oral, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

りん酸二水素ナトリウム·2水和物 上流と下流の製品情報

原材料

準備製品


りん酸二水素ナトリウム·2水和物 生産企業

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りん酸二水素ナトリウム·2水和物  スペクトルデータ(IR1)


13472-35-0(りん酸二水素ナトリウム·2水和物)キーワード:


  • 13472-35-0
  • monosodiumdihydrogenphosphatedihydrate
  • Phosphoricacid,monosodiumsalt,dihydrate
  • Phosphoricacidmonosodiumsalt,dihydrate
  • Sodiumdihydrogenphosphate,di
  • SodiumDihydrogenPhosphateDihydrateBp
  • SodiumDihydrogenPhosphateDihydrateUsp
  • MonosodiumPhosphateFoodGradeHydrous
  • SodiumDihydrogenPhosphateDihydrateIp
  • SodiumPhosphateMonobasicDihydrateFcc
  • SodiumDihydrogenPhosphateDihydrateAr
  • SodiumDihydrogenPhosphateDihydrateIp/Bp
  • MonosodiumPhosphateTechGradeHydrous
  • SODIUM PHOSPHATE MONOBASIC 2 H2O (NaH2PO4)
  • Sodium phosphate, monobasic dihydrate, for analysis, 99+%
  • Natrii dihydrogenophosphas dihydricus, Sodium dihydrogen phosphate dihydrate
  • Natriumdihydrogenphosphat
  • Sodium phosphate, monobasic dihydrate, 99+%, for analysis
  • Sodium phosphate, monobasic dihydrate, for analysis
  • Monobasic sodium phosphate·dihydrate
  • EMPROVE(R) SodiuM Dihydrogen Phosphate, Dihydrate, USP, BP, Ph Eur
  • SodiuM phosphate, Monobasic dihydrate, for analysis, 99+% 1KG
  • Sodium dihydrogen ph
  • SodiuM phosphate, Monobasic dihydrate, 98%, extra pure
  • SODIUM DIHYDROGEN PHOSPHATE DIHYDRATE P.
  • SodiuM phosphate, Monobasic dihydrate, >=99%
  • SODIUM DIHYDROGEN PHOSPHATE-2-HYDRA-TE E XTRA PURE, DAB, PH. EUR., B. P.,U.S.P.,
  • SODIUM DIHYDROGEN PHOSPHATE DIHYDRATE, F OR MOL. BIOL.
  • SODIUM DIHYDROGEN PHOSPHATE DIHYDRATE, C RYSTALLIZED
  • Sdoium phsophate monobasic dihydrate
  • Sodium dihydrogen phosphate dihydrate USP28
  • りん酸二水素ナトリウム·2水和物
  • 第一燐酸ソ-ダ 2水塩
  • りん酸二水素ナトリウム二水和物
  • りん酸一ナトリウム二水和物
  • ナトリウム ジ水素ホスフェト 二水和物
  • りん酸一ナトリウム二水和物(りん酸二水素ナトリウム二水和物)
  • りん酸二水素ナトリウム,二水和物りん酸一ナトリウム,2水和物
  • りん酸二水素ナトリウム(2水和物)
  • リン酸二水素ナトリウム水和物[CERTIPRO:薬添規、USP、PH.EUR.規格適合、エンドトキシン保証]
  • リン酸ナトリウム, 一塩基酸 二水和物
  • りん酸一ナトリウム二水和物( りん酸二水素ナトリウム二水和物)
  • りん酸二水素ナトリウム二水和物, 99%
  • りん酸二水素ナトリウム・2水和物
  • リン酸NA
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