1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール 化学特性,用途語,生産方法
外観
白色, 結晶性粉末〜粉末
溶解性
混合物 : 水5mg/l(20℃)。異性体A:水2.9mg/l(20℃)。n-ヘキサン0～1,トルエン10～20, イソプロパノール20～50, ジクロロメタン200～500 (全てg/l 20℃)。異性体B:水1.6mg/l(20℃)。n-ヘキサン0～1,トルエン1～2, イソプロパノール20～50, ジクロロメタン50～100 (全てg/l 20℃)。アセトンに溶け、水にほとんど溶けない。
説明
Bitertanol is a broad-spectrum triazole fungicide that is active against a variety of fungi, including
V. inaequalis and
V. pirina, which are responsible for apple and pear scab, respectively, as well as
S. mors-uvae and
P. ribis, which are responsible for American gooseberry mildew and leaf spot in black currants, respectively. It is active against isolates of
V. inaequalis (MICs = 0.6 and 1 μg/ml) but repeated use leads to resistance and cross-resistance (MICs = 9.8-13 μg/ml for bitertanol-resistant isolates). Bitertanol inhibits the cytochrome P450 (CYP450) isoform CYP3A4 (IC
50 = 2.74 μM) and inhibits androgenic activity induced by the androgen receptor agonist DHT in a yeast two-hybrid assay (IC
50 = 79.85 μM). In rats, bitertanol (10-300 mg/kg, i.p.) increases operant responding on one- and five-minute fixed interval schedules with no effect on motor activity.
化学的特性
White Solid
使用
Bitertanol is a foliar-applied triazole fungicide used to protect tropical and subtropical crops in agriculture, in particular bananas. Bitertanol has effects on behavior that are similar to those of psychomotor stimulants.
农业用途
Fungicide: A fungicide used to control a variety of diseases.
Used as control for prunes when drying. Not currently
registered in the U.S. or EU countries (pending). Used
in many European, South American, Far Eastern and
African countries, a well as in Australia for use on beans
(all types) and various ornamentals. More than 20 global
suppliers.
製品名
BAYCOR®; BAY KWG 0599®; BAYMATSPRAY
®; BILOXAZOL®; KWG 0599®; SIBUTOL®,
(with Fuberidazole)
代謝経路
Bitertanol is a mixture of two diastereoisomeric pairs and this complicates
its metabolism, each biotransfonnation affording a mixture of isomers.
Metabolism has been studied under environmental conditions and in
plants and mammals. Degradation in soil and sediments is slow and only
small quantities of products (other than CO
2 and bound residues) are
produced. Most information is available for mammals in which metabolism
occurs mainly by oxidative routes followed by conjugation. The
information presented below is derived from the UK MAFF Pesticide
Safety Directorate (PSD, 1994).
1-(4-ビフェニリルオキシ)-3,3-ジメチル-1-(1H-1,2,4-トリアゾール-1-イル)-2-ブタノール 上流と下流の製品情報
原材料
準備製品