スルファメラジン·ナトリウム 化学特性,用途語,生産方法
説明
Sulfamerazine is a sulfonamide antibiotic. It inhibits bacterial carbonic anhydrase by ~20% at a concentration of 500 μM.
In vivo, sulfamerazine (500 mg/L) reduces severity of peribronchitis and inhibits cilia-associated respiratory
Bacillus colonization in mice. It also prevents death of
Toxoplasma-infected mice. Sulfonamide class antibiotics, of which sulfamerazine is a member, are bacteriostatic and inhibit bacterial synthesis of dihydrofolic acid by competing with 4-aminobenzoic acid for binding to dihydropteroate synthase. Formulations containing sulfamerazine have been used for the treatment of pneumonia and typhoid fever.
使用
Involved in characterization of chirosan membranes for the transport of drugs1,2,3
世界保健機関（WHO）
Sulfamerazine sodium, a sulfonamide anti-infective agent, was
introduced several decades ago for the treatment of bacterial infections. The
importance of sulfonamides has subsequently decreased as a result of increasing
resistance and their replacement by antibiotics which are generally more active
and less toxic. The sulfonamides are known to cause serious adverse effects such
as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma
and dangerous adverse reactions affecting blood formation such as
agranulocytosis and haemolytic or aplastic anaemia. Sulfamerazine is still used in
some countries usually in combination with other sulfonamides.
安全性プロファイル
Moderately toxic by ingestion, subcutaneous, intraperitoneal, and intravenous routes. When heated to decomposition it emits toxic fumes of SOx, NOx, and Na2O.
スルファメラジン·ナトリウム 上流と下流の製品情報
原材料
準備製品