ポリ(1-ビニルピロリドン-co-酢酸ビニル) (コポリマー, 7:3) (50%エタノール溶液) 化学特性,用途語,生産方法
外観
無色～うすい黄赤色～黄色透明液体
定義
本品は、ビニルピロリドン(VP)と酢酸ビニル(VA)との共重合体である。
化粧品の成分用途
ヘアスタイリング剤、非活性剤系分散剤、結合剤、皮膜形成剤
化学的特性
white powder
使用
Poly(1-vinylpyrrolidone-co-vinyl acetate)
調製方法
Copovidone is manufactured by free-radical polymerization of
vinylpyrrolidone and vinyl acetate in a ratio of 6 : 4. The synthesis is
conducted in an organic solvent owing to the insolubility of vinyl
acetate in water.
一般的な説明
～1:2.4 mole ratio of VP:VA
応用例（製薬）
Copovidone is used as a tablet binder, a film-former, and as part of
the matrix material used in controlled-release formulations. In
tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation. Copovidone is often
added to coating solutions as a film-forming agent. It provides good
adhesion, elasticity, and hardness, and can be used as a moisture
barrier.
安全性プロファイル
Moderately toxic by ingestion.Combustible, especially in powdered form. Incompatiblewith strong oxidising agents, strong reducing agents. Whenheated to decomposition it emits toxic vapors of NOx.
安全性
Copovidone is used widely in pharmaceutical formulations and is
generally regarded as nontoxic. However, it is moderately toxic by
ingestion, producing gastric disturbances. It has no irritating or
sensitizing effects on the skin. A study was conducted to look at the
carcinogenicity and chronic toxicity of copovidone (Kollidon VA
64) in Wistar rats and Beagle dogs. The results of these studies
demonstrated the absence of any significant toxicological findings
of high dietary levels of copodivone in rats and dogs, resulting in noobserved-
adverse-effect levels of 2800 mg/kg body-weight/day in
rats and 2500 mg/kg body-weight/day in dogs, the highest doses
tested.
LD
50 (rat, oral): >0.63 g/kg
貯蔵
Copovidone is stable and should be stored in a well-closed container
in a cool, dry place.
不和合性
Copovidone is compatible with most organic and inorganic
pharmaceutical ingredients. When exposed to high water levels,
copovidone may form molecular adducts with some materials; see
Crospovidone and Povidone.
規制状況(Regulatory Status)
Copovidone is included in the FDA Inactive Ingredients Database
(oral tablets, oral film-coated tablets, sustained action).
ポリ(1-ビニルピロリドン-co-酢酸ビニル) (コポリマー, 7:3) (50%エタノール溶液) 上流と下流の製品情報
原材料
準備製品