ダナゾール 化学特性,用途語,生産方法
外観
白色～うすい黄色, 結晶～粉末
溶解性
メタノールに可溶
用途
テストステロン誘導体です。
下垂体からのゴナドトロピン分泌を抑制し、
卵巣でのエストロゲン産生低下作用を示しま
す。
効能
子宮内膜症治療薬, 下垂体前葉抑制薬
商品名
ボンゾール (田辺三菱製薬); ボンゾール (田辺三菱製薬)
化学的特性
White Solid
使用
Danazol is an anterior pituitary supressant. Danazol is an anabolic steroid derivative of ethisterone, with mild androgenic side effects (an impeded androgen). Antigonadotropin.
適応症
Danazol, a synthetic androgen, has been used to treat the pruritus of primary
biliary cirrhosis, urticaria, and also idiopathic pruritus. It has been used for treatment of pruritus associated with polycythemia
vera and systemic lupus erythematosus.
一般的な説明
Danazol, 17α-pregna-2,4-dien-20-yno-[2,3-d]isoxazol-17-ol, is a weak androgen that, in spite ofthe 17α-ethinyl group, has little estrogenic or progestogenicactivity. Danazol has been called a synthetic steroidwith diverse biological effects. Danazol binds to sexhormone–binding globulin (SHBG) and decreases the hepaticsynthesis of this estradiol and testosterone carrier.Free testosterone thus increases. Danazol inhibits FSH andLH production by the hypothalamus and pituitary. It bindsto PRs, GRs, ARs, and ERs. Although the exact mechanismof action is unclear, danazol alters endometrial tissueso that it becomes inactive and atrophic, which allowsdanazol to be an effective treatment for endometriosis.Danazol is also used to treat hereditary angioedema and fibrocysticbreast disease.
副作用
Danazol, a synthetic analogue of 17α-ethynyl testosterone, induces amenorrhea, anovulation and endometrial atrophy via suppression of the hypothalamicpituitary-ovary (HPO) axis. This causes an estrogen-deficient state, but it also causes an increase in androgen production. Danazol generally is not well tolerated because of its androgenic and anabolic side effects, including acne, decreased breast size, facial hair, weight gain, and oily skin. This type of therapy is not a viable option for women with liver disease or hyperlipidemia. Because danazol is teratogenic , it is recommended that effective contraception be utilized during treatment.
ダナゾール 上流と下流の製品情報
原材料
準備製品