シムバスタチン 化学特性,用途語,生産方法
外観
白色～ほとんど白色、結晶～粉末白色～ほとんど白色, 結晶～粉末
溶解性
アセトニトリルに可溶
解説
シンバスタチン，C25H38O5(418.57)．コンパクチンからの半合成品．白色の粉末．融点135 ℃．エタノール，アセトン，アセトニトリルに易溶，ジエチルエーテルに難溶，水に不溶．高脂血症治療剤で，コレステロール生合成系律速酵素HMG-CoA還元酵素をきっ抗的に阻害する抗生物質として使用される．
用途
HMG-CoA 還元酵素阻害剤です。
用途
HMG-CoA還元酵素阻害剤です。 HMG-CoA（3-Hydroxy-3-methylglutarylcoenzyme A）還元酵素を阻害することでコ レステロール合成の抑制作用を示します。
効能
脂質異常症治療薬, HMG-CoA還元酵素阻害薬
商品名
リポバス (MSD)
説明
Simvastatin is an once-daily hypolipemic, an analog of lovastatin indicated for the
treatment of atherosclerosis. In patients with Type IN or IIB hypercholesterolemia,
simvastatin reportedly produces significant reductions in total serum cholesterol, LDL,
mglycerides and apolipoprotein-B, while HDL and apolipoprotein-A levels are increased.
化学的特性
White Powder
使用
Simvastatin is a synthetic derivate of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.
定義
ChEBI: A carbobicyclic compound that is lovastatin in which the 2-methylbutyrate ester moiety has been replaced by a 2,2-dimethylbutyrate ester group. It is used as a cholesterol-lowering and anti-cardiovascular disease drug.
一般的な説明
Simvastatin, 2,2-dimethyl butanoic acid,1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2-pyran-2-yl)ethyl]-1-naphthalenyl ester(Zocor), is an analog of lovastatin. These two drugs havemany similar properties. Both drugs, in the prodrug form,reach the liver unchanged after oral administration, wherethey undergo extensive metabolism to several open-ring hydroxyacids, including the active -hydroxy acids. They arealso highly bound to plasma proteins. These actions makethe bioavailability of simvastatin rather poor but better thanthat of lovastatin, which has been estimated to be 5%.
生物活性
HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, and anticancer and anti-inflammatory activity.
シムバスタチン 上流と下流の製品情報
原材料
準備製品