3-ピペコリン 化学特性,用途語,生産方法
外観
無色～うすい黄色～うすい黄赤色透明液体
化学的特性
clear colorless to yellow liquid
使用
3-Methylpiperidine, is used as a reactant for synthesis of Phenylpropenamide derivatives for anti-hepatitis B virus activity, CB2 receptor agonists for treatment of chronic pain, aurora kinase inhibitors, spiroimidazolidinone NPC1L1 inhibitors, 1,3,5-Oxadiazinones, selective serotonin 5-HT6 receptor antagonists. It is also used as a pharmaceutical intermediate and as a intermediate in organic synthesis.
一般的な説明
A colorless liquid with a characteristic odor. Less dense than water. Flash point less than 141°F. Contact may cause severe irritation to skin, eyes, and mucous membranes. Toxic by ingestion, inhalation and skin absorption.
空気と水の反応
Highly flammable. Water soluble.
反応プロフィール
3-METHYLPIPERIDINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Generates flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.
健康ハザード
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
火災危険
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
純化方法
Purify it via the hydrochloride (m 172o). The hydrobromide has m 162-163o(from iso-PrOH). [Chapman et al. J Chem Soc 1925 1959, Beilstein 20 III/IV 1499, 20/4 V 100.]
3-ピペコリン 上流と下流の製品情報
原材料
準備製品