| | 155141-29-0 Basic information More.. |
| Product Name: | Rosiglitazone maleate | | Synonyms: | 5-((4-[2-(METHYL-2-PYRIDINYLAMINO)-ETHOXY]-PHENYL)-METHYLENE)-2,4-THIAZOLIDINEDIONE;5-{p-[2-(methyl-2-pyridylamino)ethoxy]benzyl}-2,4-thiazolidinedione maleate;ROSIGLITAZONE MALEATE;RosiglitazoneTartrate;Avandi;BRL-49653c;RSIGLITAZONEMALEATE;5-(4-(2-(Methyl(pyridin-2-yl)aMino)ethoxy)benzyl)thiazolidine-2,4-dione Maleate | | CAS: | 155141-29-0 | | MF: | C22H23N3O7S | | MW: | 473.5 | | EINECS: | 642-163-6 | | Mol File: | 155141-29-0.mol |  |
Use
Rosiglitazone maleate, belongs to a novel class of thiazolidine diones
launched for the treatment of non-insulin-dependent diabetes mellitus (NIDDM),
a disease characterized by a pancreatic β-cell defect and insulin resistance in
the liver and peripheral tissues. The racemic base can be obtained by
KnSvenagel condensation between 2, 4-thiazolidinedione and the corresponding
4-substituted benzaldehyde (itself prepared in 2 steps from 2-chloropyridine),
followed by reduction of the benzylidene. Rosiglitazone was shown to be a
potent agonist of peroxisome proliferator activated receptor-gamma (PPARgamma),
a nuclear receptor involved in the differentiation of adipose tissue,
without activating liver PPAR-alpha receptors. This activation of PPAR-gamma
could mediate the down-regulation of leptin gene expression. In animal models,
Rosiglitazone has been shown to normalize glucose metabolism and reduce the
exogenous dose of insulin needed to achieve glycemic control. In patients with
Type II diabetes, daily doses (4 or 8 mg) of Rosiglitazone significantly improved
blood sugar control without affecting cardiac structure or function.
- Rosiglitazone maleate
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- US $80.00 / KG
- 2023-03-27
- CAS:155141-29-0
- Min. Order: 1KG
- Purity: 99.9%
- Supply Ability: 500MT/month
- Rosiglitazone maleate
-
- US $0.00-0.00 / kg
- 2023-02-14
- CAS:155141-29-0
- Min. Order: 1kg
- Purity: 98.0%
- Supply Ability: 1kg/month
- Rosiglitazone maleate
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- US $15.00-10.00 / KG
- 2021-08-11
- CAS:155141-29-0
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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155141-29-0
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