Mizoribine

Use

Mizoribine is a kind of imidazole nucleoside isolated from the culture medium of ascomycetes M-2166 separated from the soil by Japanese scholars Asahi Kasei, being the metabolite which inhibiting the purine synthesis pathway of nucleic acid, mainly being used for inhibiting the rejection reaction before or after renal transplantation and also used for liver transplantation and autoimmune diseases. Mizoribine, as a kind of immunosuppressant, its immunosuppressive effects may be related to its inhibition of purine nucleotide synthesis and increased transcriptional activity of the glucocorticoid receptor. It has been applied at Japanese clinical renal transplantation since December 1991. Many Japanese clinical transplant centers have applied mizoribine as the routine immunization inhibitory drug after kidney transplantation. In recent year, China has also applied kidney transplant anti-rejection drugs for clinical purpose. Mizoribine, compared with similar drugs azathioprine, has a low liver toxicity and bone marrow suppression effect with its main adverse reaction being the gastrointestinal reactions, blood disorders and allergic symptoms, and occasionally bone marrow suppression and acute renal failure.

Mizoribine manufacturers

• Mizoribine
• 
• US $0.00 / KG
• 2023-01-31
• CAS:50924-49-7
• Min. Order: 1KG
• Purity: 99%
• Supply Ability: 50000KG/month

• Mizoribine
• 
• US $0.00 / g
• 2021-10-15
• CAS:50924-49-7
• Min. Order: 1g
• Purity: 98%min
• Supply Ability: 50kg

• Mizoribine USP/EP/BP
• 
• US $1.10 / g
• 2021-08-18
• CAS:50924-49-7
• Min. Order: 1g
• Purity: 99.9%
• Supply Ability: 100 Tons min