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Thiamphenicol

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Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
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Products Intro: Product Name:Thiamphenicol
CAS:15318-45-3
Purity:99% Package:352/KG
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Products Intro:Product Name:thiamphenicol
CAS:15318-45-3
Purity:99% HPLC Package:1KG;25KG
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Products Intro:Product Name:Thiamphenicol
CAS:15318-45-3
Purity:99%
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Products Intro:Product Name:ThiaMphenicol
CAS:15318-45-3
Purity:98% Package:25G,5G
Company Name: Meryer (Shanghai) Chemical Technology Co., Ltd.  
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Products Intro:Product Name:ThiaMphenicol
CAS:15318-45-3
Purity:>98.0%(LC)(N) Package:5g;25g Remarks:T2802
Thiamphenicol Basic information
Broad-spectrum antibiotic chloramphenicol Chemical Properties Uses
Product Name:Thiamphenicol
Synonyms:THIAMPHENICOL;methylsulfonyl chloramphenicol;D-THREO-2,2-DICHLORO-N-(BETA-HYDROXY-ALPHA-[HYDROXYMETHYL]-4-[METHYLSULFONYL]PHENETHYL)ACETAMIDE;D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-P-(METHYL-SULFONYL)PHENETHYL]ACETAMIDE;8065c.b.;acetamide,2,2-dichloro-n-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl;dextrosulphenidol;thiocymetin
CAS:15318-45-3
MF:C12H15Cl2NO5S
MW:356.22
EINECS:239-355-3
Product Categories:Antibiotics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;CAPITROL
Mol File:15318-45-3.mol
Thiamphenicol Structure
Thiamphenicol Chemical Properties
Melting point 163-166 °C
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility ethanol: 50 mg/mL, clear, colorless
color white to off-white
Water Solubility Soluble in acetonitrile or DMF. Slightly soluble in water
Merck 13,9372
EPA Substance Registry SystemAcetamide, 2,2-dichloro-N-[(1R,2R)-2- hydroxy-1-(hydroxymethyl)- 2-[4-(methylsulfonyl)phenyl] ethyl]-(15318-45-3)
Safety Information
Safety Statements 22-24/25
WGK Germany 2
RTECS AB6680000
MSDS Information
ProviderLanguage
Methylsulfonyl chloramphenicol English
SigmaAldrich English
Thiamphenicol Usage And Synthesis
Broad-spectrum antibiotic chloramphenicolThiamphenicol is a broad-spectrum antibiotic chloramphenicol, which is more effective to the gram-negative bacteria than the gram-positive bacteria. At room temperature, it is a white to off-white crystalline powder or crystal, which can be quickly and completely absorped by oral adminstration, as well as it is excreted mainly in the prototype from the urine for metabolism. It is clinically applied for the treatment of respiratory, urinary tract, liver and gallbladder, typhoid and other intestinal surgery, gynecology and ENT infections. Especially in the mild infections it is more effective. It has the similar chemical structure with the chloramphenicol. Its methyl sulfone substituted the nitro of chloramphenicol, which reduced its toxicity, and in vivo its antibacterial activity is 2.5-5 times stronger than chloramphenicol. For gram-positive bacteria, such as streptococcus pneumoniae and hemolytic streptococcus, it has very strong antibacterial effect, while for gram-negative bacteria, such as Neisseria gonorrhoeae, meningococcus, lung Bacteroides, E. coli, Vibrio cholerae, Shigella and influenza bacillus, it also has strong antibacterial effect. For anaerobic bacteria, Rickettsia and amoeba, it has antibacterial effect in some extent. It has the same antimicrobial mechanism with chloramphenicol, which mainly inhibits the synthesis of bacterial protein. This drug is absorped quickly by oral administration, which reaches peak blood concentration within two hours. Its half-life is 5 hours, that is more longer than chloramphenicol. The bacteria have complete cross resistance to it and chloramphenicol, while the bacteria have some cross-resistance phenomenon to it and tetracycline.
Thiamphenicol also has strong immunosuppressive effects, which is an excellent immunosuppressant. Its mechanism of action have significantly different with other immunosuppressive agents. The immunosuppressive effect is several times higher than the chloramphenicol. It can be as the effective extender for transplantation reaction and surgically allogeneic transplantation.
Domestic production of thiamphenicol enteric-coated tablets for the treatment of susceptible strains, such as Haemophilus influenzae, Escherichia coli, Salmonella and others which lead to respiratory, urinary tract, intestinal and other infections.
The main manufacturers are Jiangxi Gan River Pharmaceutical Co., Ltd. and Jiangsu morning licensing Pharmaceutical Co., Ltd.
Dosage: oral. Adult, 1.5~3g/day, 3 to 4 times a day. according to body weight for children 25~50mg/Kg, 4 times a day.
Note: it can inhibit the generation of red blood cells, white blood cells and platelet, but the degree is light than chloramphenicol. It can cause peripheral neuropathy.
The above information is edited by the chemicalbook of Kui Ming.
Chemical PropertiesWhite to off-white crystalline powder or crystal. Melting point (℃) 178-180 (swirled), 164-166 (right-handed).
UsesIt is applied for the treatment of respiratory, urinary tract, liver and gallbladder, typhoid and other intestinal surgery, gynecology and ENT infections. Especially in the mild infections it is more effective.
Chemical PropertiesOff-White Solid
UsesAntimicrobial
Useschelating agent, antiseborrheic
UsesThiamphenicol is an antibiotic. Thiamphenicol is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Thiamphenicol is used particul arly for the treatment of sexually transmitted infections and pelvic inflammatory disease.
UsesThiamphenicol is a semi-synthetic chloramphenicol prepared by total synthesis from thiophenol in which the nitro moiety of chloramphenicol is replaced by a methylsulphone, first synthesised at Sterling Winthrop in 1952. Thiamphenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Thiamphenicol acts by binding to the 23S sub-unit of the 50S ribosome inhibiting protein synthesis. Thiamphenicol has been extensively studied with over 800 literature citations.
Thiamphenicol Preparation Products And Raw materials
Raw materialsEtanol-->Bromine-->Glycine-->Dichloroacetic acid methyl ester-->1-Methyl-4-(methylsulfonyl)-benzene
Tag:Thiamphenicol(15318-45-3) Related Product Information
Acetamide Thiamphenicol Amine,Thiamphenicol Sulfone Amine racefenicol ThiamphenicolBp98 Thiamphenicol amino-compound Thiamphenicol ester-compound THIAMPHENICOLGLYCLINATEHCL Thiamphenicol Aminoacetate Ester Hydrochloride thiamphenicol glycinate acetylcysteinate thiamphenicol acetyltransferase Thiamphenicol glycinate THIAMPHENICOL PALMITATE,THIAMPHENICOL PALMITATE HCL thiamphenicol glycine hydrochloride,THIAMPHENICOL GLYCINATE HCL,THIAMPHENICOL GLYCINATE HYDROCHLORIDE,Thiamphenicol Glycinatd,thiamphenicol aminoacetate hydrochloride [R-(R*,R*)]-2-[(dichloroacetyl)amino]-3-hydroxy-3-[4-(methylsulphonyl)phenyl]propyl palmitate Thiamphenicol Chloramphenicol Florfenicol demethylvancomycin