G-谷氨酸-半胱-三氟乙酸盐
| 中文名称 | G-谷氨酸-半胱-三氟乙酸盐 |
|---|---|
| 中文同义词 | 5-L-谷氨酰-L-半胱氨酸,谷胱甘肽杂质D;Γ-谷氨酰-半胱氨酸;GAMMA-L-谷氨酰-L-半胱氨酸;谷胱甘肽杂质D;G-谷氨酸-半胱-三氟乙酸盐;Γ-谷氨酸-半胱氨酸;谷胱甘肽EP杂质D;L-Γ-谷氨酰-L-半胱氨酸 |
| 英文名称 | GAMMA-GLU-CYS TRIFLUOROACETATE SALT |
| 英文同义词 | gamma-glutamylcysteine;H-GLU(CYS-OH)-OH TFA;GAMMA-GLU-CYS TRIFLUOROACETATE SALT;(DES-GLY)-GLUTATHIONE TFA (REDUCED);G-glu-cys trifluoroacetate;des-gly-glutathione reduced form;γ-glu-cys;2-amino-5-(1-carboxy-2-sulfanyl-ethyl)amino-5-oxo-pentanoic acid |
| CAS号 | 636-58-8 |
| 分子式 | C8H14N2O5S |
| 分子量 | 250.27 |
| EINECS号 | |
| 相关类别 | 化学生物学;多肽合成;二肽;定做 |
| Mol文件 | 636-58-8.mol |
| 结构式 |  |
G-谷氨酸-半胱-三氟乙酸盐 性质
| 熔点 | 167℃ |
|---|---|
| 沸点 | 592.4±50.0 °C(Predicted) |
| 密度 | 1.436±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 水中 ≥ 25mg/mL，DMSO 中 ≥ 52 mg/mL，乙醇中 ≥ 54.8 mg/mL |
| 酸度系数(pKa) | 2.21±0.10(Predicted) |
| InChIKey | RITKHVBHSGLULN-WHFBIAKZSA-N |
Gamma-glutamylcysteine (γ-Glutamylcysteine) 是一种含有半胱氨酸和谷氨酸的二肽，是谷胱甘肽 (GSH) 的前体。Gamma-glutamylcysteine 是谷胱甘肽过氧化物酶 (GPx) 增加 GSH 水平的辅助因子。
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Human Endogenous Metabolite
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Co-treatment of Aβ40 oligomers with Gamma-glutamylcysteine (γ-Glutamylcysteine; GGC) at 200 μM increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and leads to significant increases in the levels of the total antioxidant capacity (TAC) and GSH and reduces the GSSG/GSH ratio. Gamma-glutamylcysteine also upregulates the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes.
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英文
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