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Barbituric acid

Barbituric acid Suppliers list
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Products Intro: Product Name:Barbituric acid
CAS:67-52-7
Purity:99% Package:66/KG
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Products Intro:CAS:67-52-7
Purity:99% HPLC Package:5g;25g;100g;500g;1Kg
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Products Intro:Product Name:Barbituric acid
CAS:67-52-7
Purity:AR,99.5% Package:25g
Company Name: Shanghai Xilong Biochemical Technology Co., Ltd.  Gold
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Products Intro:CAS:67-52-7
Purity:98% Package:65RMB/25g
Company Name: Hebei Aopharm Medical Tech Co., Ltd  Gold
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Products Intro:Product Name:Barbituric acid
CAS:67-52-7
Barbituric acid Basic information
Barbiturates Chemical Properties Uses production method Category Toxicity grading Acute toxicity Explosive hazardous characteristics Flammability hazard characteristics Storage Characteristics extinguishing agent
Product Name:Barbituric acid
Synonyms:Fluorouracil Related CoMpound A;Babituric acid dihydrate;Barbituric acid ReagentPlus(R), 99%;S ACID ( OTHER DERIVATIVES OF MALONYLURIA;SPECS AG-670/31547005;TIMTEC-BB SBB004242;PYRIMIDINE TRIONE;N,N'-MALONYLUREA
CAS:67-52-7
MF:C4H4N2O3
MW:128.09
EINECS:200-658-0
Product Categories:Heterocycle-Pyrimidine series;Indolines ,Indoles ,Indazoles;Pharmaceutical Intermediates;PYRIMIDINE;Miscellaneous Biochemicals;Pyrimidine series;Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals
Mol File:67-52-7.mol
Barbituric acid Structure
Barbituric acid Chemical Properties
Melting point 248-252 °C (dec.)(lit.)
Boiling point 260℃ (分解)
Fp 150 °C
storage temp. Store below +30°C.
solubility 11.45g/l
pka4.01(at 25℃)
form Powder/Solid
color Light Cream
PH2-3 (50g/l, H2O, 60℃)
Water Solubility 142 g/L (20 ºC)
Merck 14,963
BRN 120502
CAS DataBase Reference67-52-7(CAS DataBase Reference)
NIST Chemistry ReferenceBarbituric acid(67-52-7)
EPA Substance Registry System2,4,6(1H,3H,5H)- Pyrimidinetrione(67-52-7)
Safety Information
Risk Statements 36/37/38
Safety Statements 24/25
WGK Germany 1
RTECS CP8000000
TSCA Yes
HS Code 29335200
MSDS Information
ProviderLanguage
Malonylurea English
SigmaAldrich English
ACROS English
ALFA English
Barbituric acid Usage And Synthesis
BarbituratesBarbiturates are derivatives of barbituric acid, barbituric acid is formed by the condensation of malonic acid and urea, itself has no anesthetic effect, but if its C2 and C5 atoms are substituted by different genes, it can generate many species of barbiturate agents ,for example, oxygen of C2 is replaced by sulfur, which generates sulfur barbiturates, such as thiopental.
Barbiturates’ mechanism is basically the same, they act on different levels of the central nervous system, and have a non-specific inhibition. Its sedative and hypnotic effects may be related to selective inhibition of thalamic reticular upstream activating system , thereby blocking the excite transduction to cerebral cortex. Its Anticonvulsant effect is performed through inhibiting synaptic transmission in the central nervous system ,to improve the electrical stimulation threshold in motor cortex.
barbiturates having a therapeutic effect play a inhibiting role in the central nervous system , such as phenobarbital (phenobarbitone), amobarbital (amylobarbitone), thiopental , methohexital (methohexi-tone ). Inhibitory barbiturates have sedative, hypnotic, anticonvulsant and anesthetic effects, but its sedative-hypnotic agent has been eliminated, because in the process it is easy to produce severe tolerance, drug dependence and drug liver enzyme induction.
Because of some differences in their chemical structure, the body eliminate and fat-soluble manner of every drug are different , thus the speed of appearing effect and time of continuing also vary . Long-acting barbiturates such as phenobarbital (phenobarbi-tone) are still used in the treatment of epilepsy anticonvulsant. Ultrashort acting barbiturates (thiopental and methohexital) are often applied as an intravenous anesthetic.
Barbiturate intravenous anesthetics used clinically are now about ten kinds, but three to five species are commonly used . According to the view of Anesthesiology, barbiturates can be divided into two categories, namely hypnotic barbiturates and barbiturate anesthesia. The former are markedly slower drugs such as phenobarbital,having a sedative effect, before anesthesia,its administration can make the patient quiet. After intravenous injection of the latter, consciousness soon disappear,it is mainly used for general anesthesia, in which the most commonly used drug is thiopental, so this drug is representative.
Phenobarbital is a barbituric acid derivative, having weak acid,it is the central inhibitor, mainly inhibiting brain ascending reticular activating system. The shallow to deep degree of inhibition of the drug are due to the amount of small to large ,it has different levels of sedative, hypnotic and anticonvulsant, anesthetic effect. In addition, the drug also has antiepileptic effect.
The above information is edited by the chemicalbook of Tian Ye.
Chemical PropertiesWhite crystalline powder. Odorless. Soluble in water and ether, insoluble in water and alcohol.
UsesIt is used for intermediate of organic synthesis raw materials, pharmaceuticals, plastics and dyes. It Is the intermediate of phenobarbital, vitamin B12 and other drugs,it is also used as a polymerization catalyst and the preparation of benzimidazolone-based organic pigments. Also it is used as colorimetric determination of uronic and pentosan reagents.
production methodIt is derived By the reaction of diethyl malonate and urea. First put Urea in a reaction tank containing methanol ,heat , reflux , dissolve, then add the dried diethyl malonate and sodium methoxide, the reaction is refluxed at 66-68 ℃ for 4-5h, after distillation to recover methanol, cooling to 40-50 ℃, add dilute hydrochloric acid to adjust to pH 1-2.Cool to room temperature, throw to obtain crude, wash with distilled water once, dry to get crude , and then purify with water and activated carbon, dry to obtain products. Industrial barbituric acid is white or pink crystalline powder, strongly acidic, more than 98% content, melting point ≥245 ℃. Material consumption fixed: diethyl malonate 1098kg/t, urea 476kg/t, hydrochloric acid (reagent grade Ⅲ) 681kg/t, sodium methanol (28%) 369kg/t, methanol 1025kg/t.
CategoryFlammable liquid
Toxicity gradingMiddle toxic
Acute toxicityoral-rat LD50:> 5000 mg/kg; intraperitoneal-Mouse LD50: 505 mg/kg
Explosive hazardous characteristicsallergic effect
Flammability hazard characteristicsEasily flammable; burning produces toxic nitrogen oxide fumes; people taking has no hypnotic effect
Storage CharacteristicsVentilated, low-temperature ,dry
extinguishing agentDry powder , foam, sand, carbon dioxide, water spray
Chemical PropertiesCREAM COLOURED FINE CRYSTALLINE POWDER
UsesBarbituric acid is a parent compound of barbiturate drugs. Unsubstituted barbituric acid has no hypnotic properties.
DefinitionChEBI: A barbiturate, the structure of which is that of perhydropyrimidine substituted at C-2, -4 and -6 by oxo groups. Barbituric acid is the parent compound of barbiturate drugs, although it is not itself pharmacologically active.
Tag:Barbituric acid(67-52-7) Related Product Information
Folic acid Stearic acid Malonic acid Citric acid Diethyl malonate Barbituric acid, 1,3-dimethyl- Hyaluronic acid propanedial Biuret ANISYLIDENE BARBITURIC ACID ALLOXANTIN Barbituric acid, 5,5'-nitrilodi-, monoammonium salt 5-NITROHEXAHYDROPYRIMIDINE-2,4,6-TRIONE HYDRATE AURORA KA-5201 Barbituric acid, 5-oxo- 4-HYDROXYPHENOBARBITAL URAMIL-N,N-DIACETIC ACID Pentobarbital sodium