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Sofosbuvir Suppliers list
Company Name: Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel: 025-84209270 15906146951
Products Intro: Product Name:Sofosbuvir
Purity:99% Package:50KG;25KG;10KG;5KG;1KG
Company Name: Frapp's ChemicalNFTZ Co., Ltd.
Tel: +86 (576) 8169-6106
Products Intro: Product Name:Sofosbuvir
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Products Intro: Product Name:Sofosbuvir
Purity:99%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55541817
Products Intro: Product Name:Sofosbuvir
Purity:99% Package:100grams;500grams;1kg;5kg;10kg;25kg
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Products Intro: Product Name:Sofosbuvir
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Sofosbuvir Basic information
Indications and Usage Mechanisms of Action
Product Name:Sofosbuvir
Synonyms:Sofosbuvir (PSI-7977, GS-7977);Sofosbuvir N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester;propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate;Suofeibuwei;Sofosbuvir, >=98%;Sofosbubir;Sofosbuvir,GS-7977;(S)-Isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-h
Product Categories:API;Inhibitors;Liver Disease Series;PSI7977;Pharmaceutical intermediate
Mol File:1190307-88-0.mol
Sofosbuvir Structure
Sofosbuvir Chemical Properties
density 1.41
Safety Information
MSDS Information
Sofosbuvir Usage And Synthesis
Indications and UsageSofosbuvir is the world’s first oral drug for treating hepatitis C and was one of the most important new drugs to be approved in the U.S.A in 2013. It was developed by the American Gillard Scientific Company. It eliminates the need for traditional injection drug interferon (IFN) when treating genotype-specific hepatitis C.
Sofosbuvir is used to treat chronic hepatitis C virus (HCV) infections. It is the first safe and effective drug that does not require IFN when treating HCV infections. There are a few different types of HCV infections. According to the type of infection, treatment regimens can include sofosbuvir and ribavirin, or sofosbuvir, ribavirin and pegylated interferon α.
Mechanisms of ActionSofosbuvir is a type of nucleotide analogue inhibitor. It prevents hepatitis C virus (HCV) from replicating a crucial type of specific protein.
DescriptionSofosbuvir is a drug used for the treatment of hepatitis C. It is recommended to be used in combination with other drugs (such as velpatasvir) for the first-line treatment for HCV genotypes 1, 2, 3, 4, 5, and 6. It takes effect through acting as a nucleotide analog inhibitor, being capable of specially inhibiting the HCV NS5B (non-structural protein 5B) RNA-dependent RNA polymerase.
UsesPSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the t reatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
DefinitionChEBI: A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.
UsesPSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.[Cayman Chemical]
Sofosbuvir Preparation Products And Raw materials
Tag:Sofosbuvir(1190307-88-0) Related Product Information
PSI-6130 derivative AZD-8055 Selumetinib 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Daclatasvir (BMS-790052) Etravirine (TMC125) Entinostat D-Arabinonic acid, 2-C-methyl-4,5-O-(1-methylethylidene)-,ethyl ester ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate 2'-deoxy-2'-fluoro-2'-C-methyluridine