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ChemicalBook Optimization Suppliers |
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| 融点 | 284-289 °C(lit.) | | 沸点 | 295.4±42.0 °C(Predicted) | | 比重(密度) | 1.32±0.1 g/cm3(Predicted) | | 貯蔵温度 | Keep in dark place,Sealed in dry,Room Temperature | | 溶解性 | DMSO | | 酸解離定数(Pka) | 8.39±0.10(Predicted) | | 外見 | Crystalline Powder | | 色 | Off-white to beige | | 水溶解度 | 2.5 g/100 mL | | BRN | 2936346 | | InChI | InChI=1S/C6H6BClO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H | | InChIKey | CAYQIZIAYYNFCS-UHFFFAOYSA-N | | SMILES | B(C1=CC=C(Cl)C=C1)(O)O | | CAS データベース | 1679-18-1(CAS DataBase Reference) |
| | 4-クロロフェニルボロン酸 Usage And Synthesis |
| 外観 | 白色～うすい黄褐色、結晶～結晶性粉末 | | 用途 | 有機合成原料。 | | 化学的特性 | off-white to beige crystalline powder | | 化学的特性 | 4-Chlorophenylboronic acid is white or off-white crystalline powder. It has certain solubility in water and is soluble in strong polar organic solvents such as dimethyl sulfoxide, but insoluble in ether solvents. It has similar chemical properties to phenylboronic acid. | | 使用 | 4-Chlorobenzeneboronic Acid is used as a catalyst for the preparation of 4-hydroxycoumarin derivatives which display antitrypanosomal and antioxidant properties. It is also used as a catalyst for the
asymmetric borane reduction of electron-deficient ketones. | | 使用 | 4-Chlorophenylboronic acid can be used as a reactant in:
- Palladium-catalyzed direct arylation.
- Cyclopalladation.
- Tandem-type Pd(II)-catalyzed oxidative Heck reaction and intramolecular C-H amidation.
- Copper-mediated ligandless aerobic fluoroalkylation.
- Pd-catalyzed arylative cyclization.
- Ruthenium catalyzed direct arylation.
- Ligand-free copper-catalyzed coupling reactions.
- Regioselective arylation and alkynylation by Suzuki-Miyaura and Sonogashira cross-coupling reactions.
It can also be used to prepare:
- Substituted diarylmethylidenefluorenes via Suzuki coupling reaction.
- Baclofen lactam by Suzuki coupling of a pyrrolinyl tosylate, followed by hydrogenation reaction.
- Palladium(II) thiocarboxamide complexes as Suzuki coupling catalysts.
- Biaryls by Suzuki reactions of aryl chlorides, bromides, and iodides with arylboronic acids.
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